Women retain insulin sensitivity better than men

March 17, 2015

Hamilton, ON (March 17, 2015) - It's long been known that obese men are more likely to develop type two diabetes than obese women, but researchers at McMaster University have discovered it may be related to a difference between the sexes in the activity of a protein in the muscle.

As people become overweight, their skeletal muscle develops insulin resistance that can lead to type two diabetes. In a paper published by Scientific Reports today, the research team found the activity of this protein, called PTEN (for Phosphatase and tensin homolog deleted on chromosome 10), is different between men and women.

When PTEN is active, it prevents insulin from signaling properly in muscle, which reduces the amount of sugar a muscle takes. This 'muscle insulin resistance' increases the chance of developing type two diabetes.

"In our study, women's muscle appeared more efficient in neutralizing this protein, and this allows insulin to work better to move sugar from circulation to muscle," said lead author Dr. M. Constantine Samaan, assistant professor of pediatrics at the Michael G. DeGroote School of Medicine and pediatric endocrinologist at the McMaster Children's Hospital

"This protein is one explanation of why women are relatively protected from type two diabetes, despite having more body fat content compared to men at a given weight," said Samaan, adding that this is important as it provides a therapeutic target to improve muscle responses to insulin to treat and prevent diabetes. The team is now working on finding out how PTEN is regulated in different cells.
-end-
The research was funded by the Canadian Heart & Stroke Foundation and Hamilton Health Sciences.

Editors: The paper, entitled "Sex differences in skeletal muscle Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) levels: A cross-sectional study" is freely available online at http://www.nature.com/scientificreports.

McMaster University

Related Diabetes Articles from Brightsurf:

New diabetes medication reduced heart event risk in those with diabetes and kidney disease
Sotagliflozin - a type of medication known as an SGLT2 inhibitor primarily prescribed for Type 2 diabetes - reduces the risk of adverse cardiovascular events for patients with diabetes and kidney disease.

Diabetes drug boosts survival in patients with type 2 diabetes and COVID-19 pneumonia
Sitagliptin, a drug to lower blood sugar in type 2 diabetes, also improves survival in diabetic patients hospitalized with COVID-19, suggests a multicenter observational study in Italy.

Making sense of diabetes
Throughout her 38-year nursing career, Laurel Despins has progressed from a bedside nurse to a clinical nurse specialist and has worked in medical, surgical and cardiac intensive care units.

Helping teens with type 1 diabetes improve diabetes control with MyDiaText
Adolescence is a difficult period of development, made more complex for those with Type 1 diabetes mellitus (T1DM).

Diabetes-in-a-dish model uncovers new insights into the cause of type 2 diabetes
Researchers have developed a novel 'disease-in-a-dish' model to study the basic molecular factors that lead to the development of type 2 diabetes, uncovering the potential existence of major signaling defects both inside and outside of the classical insulin signaling cascade, and providing new perspectives on the mechanisms behind insulin resistance in type 2 diabetes and possibly opportunities for the development of novel therapeutics for the disease.

Tele-diabetes to manage new-onset diabetes during COVID-19 pandemic
Two new case studies highlight the use of tele-diabetes to manage new-onset type 1 diabetes in an adult and an infant during the COVID-19 pandemic.

Genetic profile may predict type 2 diabetes risk among women with gestational diabetes
Women who go on to develop type 2 diabetes after having gestational, or pregnancy-related, diabetes are more likely to have particular genetic profiles, suggests an analysis by researchers at the National Institutes of Health and other institutions.

Maternal gestational diabetes linked to diabetes in children
Children and youth of mothers who had gestational diabetes during pregnancy are at increased risk of diabetes themselves, according to new research published in CMAJ (Canadian Medical Association Journal).

Two diabetes medications don't slow progression of type 2 diabetes in youth
In youth with impaired glucose tolerance or recent-onset type 2 diabetes, neither initial treatment with long-acting insulin followed by the drug metformin, nor metformin alone preserved the body's ability to make insulin, according to results published online June 25 in Diabetes Care.

People with diabetes visit the dentist less frequently despite link between diabetes, oral health
Adults with diabetes are less likely to visit the dentist than people with prediabetes or without diabetes, finds a new study led by researchers at NYU Rory Meyers College of Nursing and East Carolina University's Brody School of Medicine.

Read More: Diabetes News and Diabetes Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.