Nav: Home

Trauma relapse in a novel context may be preventable

March 18, 2020

Korea Brain Research Institute (KBRI, President: Pann-Ghill Suh) announced on February 10 that its research team led by Dr. Ja Wook Koo and Dr. Sukwon Lee proved that the posterior parietal cortex (PPC) of the cerebrum plays a role in fear renewal occurring in a novel context.

Posterior parietal cortex (PPC): The posterior parietal cortex is a part of the parietal lobe located in the upper-rear part of the brain and is related to high-level cognitive functions of the brain, including spatial reasoning and decision-making.

The findings were published in the February issue of the international scientific journal Molecular Brain. The title of the paper and its authors are as below.

Title: Posterior parietal cortex mediates fear renewal in a novel context *

Authors: Bitna Joo (first author), Ja Wook Koo, and Sukwon Lee (corresponding authors)

Posttraumatic stress disorder (PTSD) is a mental health condition 'where' a person exposed to traumatic events such as severe accidents and violence repeatedly suffers from mental or physical distress. PTSD patients experience chronic distress because a mere visit to a place that reminds them of their trauma can result in relapse. For instance, some survivors of national disasters, such as the Sewol ferry incident and the Daegu subway fire, can no longer board a ship or are reluctant to use the subway in another city.

A KBRI research team has discovered, for the first time in the world, that PPC is associated with fear renewal in a novel context.

In this study, fear memory was produced in the form of associative memory through the simultaneous use of auditory and electric stimuli. This memory was a conditioned memory as shown in Pavlov's dogs salivate in response to bell ringings after several repetitions of being fed while bell ringing.

The research team exposed mice simultaneously to sound and electric shock in order to create an auditory fear memory, and then exposed them again to the same sound in a novel context.

Control mice that received no treatment exhibited the same fear response in both novel and familiar contexts, 'where'as experimental mice whose PPC was inactivated via drug treatment or light stimulation showed no fear response in a novel context. (Still, in a familiar context, their fear relapse could not be prevented.)

? The present study has proved that fear renewal in a novel context requires the activation of the PPC. The findings also suggest that, among regions of the cerebral cortex that perform high-level cognitive tasks (e.g. perception, thinking and memorizing), the PPC plays a crucial role in spatial reasoning and decision-making.

Dr. Ja Wook Koo and Dr. Sukwon Lee of KBRI stated that the research team "discovered a new role for the PPC that had previously not been fully understood" and that they hoped to "help researchers develop treatment strategies needed to prevent fear renewal from occurring in patients with PTSD and fear-related disorders."

In 2016, KBRI established the Co-operative Cerebral Cortex Research Group to study the PPC of the cerebrum. This group has been researching animal models associated with socialization and cognitive behavior, and aims to complete, by 2026, the creation of a PPC-centered functional brain map.
-end-


Korea Brain Research Institute

Related Memory Articles:

Memory of the Venus flytrap
In a study to be published in Nature Plants, a graduate student Mr.
Memory protein
When UC Santa Barbara materials scientist Omar Saleh and graduate student Ian Morgan sought to understand the mechanical behaviors of disordered proteins in the lab, they expected that after being stretched, one particular model protein would snap back instantaneously, like a rubber band.
Previously claimed memory boosting font 'Sans Forgetica' does not actually boost memory
It was previously claimed that the font Sans Forgetica could enhance people's memory for information, however researchers from the University of Warwick and the University of Waikato, New Zealand, have found after carrying out numerous experiments that the font does not enhance memory.
Memory boost with just one look
HRL Laboratories, LLC, researchers have published results showing that targeted transcranial electrical stimulation during slow-wave sleep can improve metamemories of specific episodes by 20% after only one viewing of the episode, compared to controls.
VR is not suited to visual memory?!
Toyohashi university of technology researcher and a research team at Tokyo Denki University have found that virtual reality (VR) may interfere with visual memory.
The genetic signature of memory
Despite their importance in memory, the human cortex and subcortex display a distinct collection of 'gene signatures.' The work recently published in eNeuro increases our understanding of how the brain creates memories and identifies potential genes for further investigation.
How long does memory last? For shape memory alloys, the longer the better
Scientists captured live action details of the phase transitions of shape memory alloys, giving them a better idea how to improve their properties for applications.
A NEAT discovery about memory
UAB researchers say over expression of NEAT1, an noncoding RNA, appears to diminish the ability of older brains to form memories.
Molecular memory can be used to increase the memory capacity of hard disks
Researchers at the University of Jyväskylä have taken part in an international British-Finnish-Chinese collaboration where the first molecule capable of remembering the direction of a magnetic above liquid nitrogen temperatures has been prepared and characterized.
Memory transferred between snails
Memories can be transferred between organisms by extracting ribonucleic acid (RNA) from a trained animal and injecting it into an untrained animal, as demonstrated in a study of sea snails published in eNeuro.
More Memory News and Memory Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Listen Again: The Power Of Spaces
How do spaces shape the human experience? In what ways do our rooms, homes, and buildings give us meaning and purpose? This hour, TED speakers explore the power of the spaces we make and inhabit. Guests include architect Michael Murphy, musician David Byrne, artist Es Devlin, and architect Siamak Hariri.
Now Playing: Science for the People

#576 Science Communication in Creative Places
When you think of science communication, you might think of TED talks or museum talks or video talks, or... people giving lectures. It's a lot of people talking. But there's more to sci comm than that. This week host Bethany Brookshire talks to three people who have looked at science communication in places you might not expect it. We'll speak with Mauna Dasari, a graduate student at Notre Dame, about making mammals into a March Madness match. We'll talk with Sarah Garner, director of the Pathologists Assistant Program at Tulane University School of Medicine, who takes pathology instruction out of...
Now Playing: Radiolab

What If?
There's plenty of speculation about what Donald Trump might do in the wake of the election. Would he dispute the results if he loses? Would he simply refuse to leave office, or even try to use the military to maintain control? Last summer, Rosa Brooks got together a team of experts and political operatives from both sides of the aisle to ask a slightly different question. Rather than arguing about whether he'd do those things, they dug into what exactly would happen if he did. Part war game part choose your own adventure, Rosa's Transition Integrity Project doesn't give us any predictions, and it isn't a referendum on Trump. Instead, it's a deeply illuminating stress test on our laws, our institutions, and on the commitment to democracy written into the constitution. This episode was reported by Bethel Habte, with help from Tracie Hunte, and produced by Bethel Habte. Jeremy Bloom provided original music. Support Radiolab by becoming a member today at Radiolab.org/donate.     You can read The Transition Integrity Project's report here.