Nav: Home

High-fructose corn syrup enhances tumor growth in a mouse model of intestinal cancer

March 21, 2019

In a new study, researchers have found that consumption of high-fructose corn syrup can enhance tumor growth in mice that are genetically predisposed to develop intestinal cancer. Whether these observations with mice are relevant to the development of human intestinal cancer was not addressed in the study but is an important question for future investigation. The mouse study was prompted by human epidemiological studies that had revealed a correlation between higher intake of beverages sweetened with high-fructose corn syrup (HFCS) and obesity, and by other studies that had revealed a correlation between obesity and a higher risk of colorectal cancer (CRC). Marcus Goncalves and colleagues set out to investigate whether HFCS contributes directly to tumor development in the absence of obesity. To do this, they studied mice that were genetically predisposed to develop intestinal adenomas (benign tumors that can develop into colorectal cancer). Goncalves et al. fed the animals both moderate and large amounts of HFCS and discovered that consumption of even moderate quantities of HFCS led to dramatic increases in intestinal tumor size and grade in the mice. What's more, the results demonstrate that this increase occurred independently of the common confounding conditions of obesity and metabolic syndrome. The authors next explored the molecular mechanism underlying this effect. They found that an enzyme in the mouse tumors converts fructose into fructose-1-phosphate, which alters tumor cell metabolism, creating fatty acids that support tumor growth. If future research shows that HFCS has a similar growth-enhancing effect on human tumors, the study's findings suggest that treatments targeting fructose metabolism could provide new strategies for slowing the development and progression of colorectal cancer. In a related video, one of the study's two lead authors, Dr. Lewis Cantley, discusses the study in more detail, including its limitations. The video will be available on Monday, 18 March.
-end-


American Association for the Advancement of Science

Related Obesity Articles:

Obesity is in the eye of the beholder
Doctors have a specific definition of what it means to be overweight or obese, but in the social world, gender, race and generation matter a lot for whether people are judged as 'thin enough' or 'too fat.'
Type 2 diabetes and obesity -- what do we really know?
Social and economic factors have led to a dramatic rise in type 2 diabetes and obesity around the world.
Three in 4 don't know obesity causes cancer
Three out of four (75 percent) people in the UK are unaware of the link between obesity and cancer, according to a new Cancer Research UK report published today.
Obesity on the rise in Indonesia
Obesity is on the rise in Indonesia, one of the largest studies of the double burden of malnutrition in children has revealed.
Obesity rates are not declining in US youth
A clear and significant increase in obesity continued from 1999 through 2014, according to an analysis of data on United States children and adolescents age 2 to 19 years.
How does the environment affect obesity?
Researchers will be examining how agricultural and food processing practices may affect brown fat activity directly or indirectly.
Obesity Day to highlight growing obesity epidemic in Europe
The growing obesity epidemic, which is predicted to affect more than half of all European citizens by 2030, will be the focus of European Obesity Day to be held on May 21.
Understanding obesity from the inside out
Researchers developed a new laboratory method that allowed them to identify GABA as a key player in the complex brain processes that control appetite and metabolism.
Epigenetic switch for obesity
Obesity can sometimes be shut down.
Immunological Aspects of Obesity
This FASEB Conference focuses on the interactions between obesity and immune cells, focusing in particular on how inflammation in various organs influences obesity and obesity-related complications.

Related Obesity Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Changing The World
What does it take to change the world for the better? This hour, TED speakers explore ideas on activism—what motivates it, why it matters, and how each of us can make a difference. Guests include civil rights activist Ruby Sales, labor leader and civil rights activist Dolores Huerta, author Jeremy Heimans, "craftivist" Sarah Corbett, and designer and futurist Angela Oguntala.
Now Playing: Science for the People

#520 A Closer Look at Objectivism
This week we broach the topic of Objectivism. We'll be speaking with Keith Lockitch, senior fellow at the Ayn Rand Institute, about the philosophy of Objectivism as it's taught through Ayn Rand's writings. Then we'll speak with Denise Cummins, cognitive scientist, author and fellow at the Association for Psychological Science, about the impact of Objectivist ideology on society. Related links: This is what happens when you take Ayn Rand seriously Another Critic Who Doesn’t Care What Rand Thought or Why She Thought It, Only That She’s Wrong Quote is from "A Companion to Ayn Rand"