Nav: Home

Mosquito monitoring has limited utility in dengue control, study finds

March 23, 2017

Cross-sectional surveys of mosquito abundance carried out in the subtropics and tropics are meant to give researchers an indication of the risk of a dengue virus outbreak in any given area. This type of entomological monitoring, however, is not a good proxy for dengue risk, researchers report this week in PLOS Neglected Tropical Diseases. Comparison of cross-sectional measures of mosquito density to longitudinal measures demonstrate the limitations of periodic entomological monitoring as households with exposure to Ae. aegypti may be misclassified as unexposed at any single survey visit.

Dengue is caused by any of four genetically distinct dengue viruses, all spread to humans through the bites of infected mosquitos--most commonly Aedes aegypti. Every year, an estimated 100 million people around the globe contract dengue fever, which can cause symptoms ranging from mild pain to systemic shock and death. To pinpoint which areas to target with disease intervention programs, researchers and policymakers have traditionally turned to entomological monitoring surveys that offer snapshots of mosquito abundance in communities.

In the new work, Elizabeth Cromwell, of the University of North Carolina, and colleagues analyzed data collected during two longitudinal studies in Iquitos, Peru. The datasets included both Aedes aegypti mosquito abundance and dengue virus seroconversion among humans. One study spanned 1999 to 2003, the other 2008 through 2010. In total, entomological observations from 1,377 households that contributed data on mosquitos were linked with blood samples taken approximately six months apart from 3,824 individuals.

The researchers found no association between cross-sectional measures of Aedes aegypti abundance and the risk of infection with dengue virus, as measured by the blood tests. Longitudinal indicators fared better, with individuals residing in households with evidence of adult mosquito abundance over time were between 1% and 30% more likely to have seroconverted to dengue virus.

"Our findings should be considered in the development and revision of enhanced [dengue virus] surveillance guidelines," the researchers say. "Dengue control programs weighing the operational feasibility and cost of entomological monitoring against the limited utility of these indicators may wish to seek alternative monitoring frameworks that incorporate human dengue-related outcomes, such as passive case detection and, when possible, sero-surveys and active case detection."
-end-
In your coverage please use this URL to provide access to the freely available article in PLOS Neglected Tropical Diseases: http://dx.doi.org/10.1371/journal.pntd.0005429

Citation: Cromwell EA, Stoddard ST, Barker CM, Van Rie A, Messer WB, Meshnick SR, et al. (2017) The relationship between entomological indicators of Aedes aegypti abundance and dengue virus infection. PLoS Negl Trop Dis 11(3): e0005429. doi:10.1371/journal.pntd.0005429

Funding: Funding for entomological and serological data collection was provided by the National Institutes of Health grants R01-AI42332 and R01-AI069341, the Bill and Melinda Gates Foundation grant for the Innovative Vector Control Consortium, and the Armed Forces Health Surveillance Center Global Emerging Infections Systems Research Program (847705.82000.25GB.B0016).
https://www.nih.gov/
http://www.gatesfoundation.org/
http://www.health.mil/

ACM, CMB, STS, and TWS also received support from the National Institutes of Health grant P01-AI098670.
https://www.nih.gov/

EAC was funded by the National Institutes of Health training grant 5T32AI070114.
https://www.nih.gov/

The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript

Competing Interests: The authors have declared that no competing interests exist.

PLOS

Related Dengue Virus Articles:

One step closer to a DNA vaccine against dengue virus
In a new study, researchers inoculated mice with a new DNA vaccine candidate (pVAX1-D1ME) in order to evaluate its efficiency.
8 in 10 Indonesian children has been infected with dengue
Indonesia has one of the highest burdens of dengue fever, a mosquito-borne virus, in the world, and children account for many cases.
A novel approach to seeing dengue infection in the body
Positron emission tomography (PET) paired with the glucose metabolism probe, fluorodeoxyglucose (FDG), is considered 'old' technology in the field of cancer.
Mosquitoes infected with virus-suppressing bacteria could help control dengue fever
Mosquitoes infected with the bacteria Wolbachia are significantly worse vectors for dengue virus, but how to establish and spread Wolbachia in an urban mosquito population is unclear.
Researchers identify tactic Dengue virus uses to delay triggering immune response
Mount Sinai researchers describe novel mechanism cells use to recognize earliest stages of infection and how virus evades triggering an immune response.
More Dengue Virus News and Dengue Virus Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Teaching For Better Humans
More than test scores or good grades — what do kids need to prepare them for the future? This hour, guest host Manoush Zomorodi and TED speakers explore how to help children grow into better humans, in and out of the classroom. Guests include educators Olympia Della Flora and Liz Kleinrock, psychologist Thomas Curran, and writer Jacqueline Woodson.
Now Playing: Science for the People

#534 Bacteria are Coming for Your OJ
What makes breakfast, breakfast? Well, according to every movie and TV show we've ever seen, a big glass of orange juice is basically required. But our morning grapefruit might be in danger. Why? Citrus greening, a bacteria carried by a bug, has infected 90% of the citrus groves in Florida. It's coming for your OJ. We'll talk with University of Maryland plant virologist Anne Simon about ways to stop the citrus killer, and with science writer and journalist Maryn McKenna about why throwing antibiotics at the problem is probably not the solution. Related links: A Review of the Citrus Greening...