Identifying fatty acid-binding protein 4 as a responsible gene for renal stone formation

March 23, 2020

Kidney stone disease has a high prevalence worldwide, ranging up to 13% in North America, 9% in Europe, and 5% in Asia. They are painful for patients, often lead to surgery, and impart a significant economic impact. Many have reported nephrolithiasis (NL) to be associated with metabolic syndrome, but the mechanism by which they are linked is not understood. This poorly characterized association affords an opportunity to identify new targets that may lead to medical prevention of kidney stone recurrence.

In this study, Dr. Kazumi Taguchi (Assistant Professor, Nagoya City University), Dr. Takahiro Yasui (Professor, Nagoya City University), Dr. Thomas Chi (Associate Professor, University of California San Francisco), and their collaborators investigated gene expression profiling of nephrolithiasis patients by two RNA-sequencing approaches: comparison between renal papilla tissue with and without the presence of calcified Randall's plaques, and comparison between the papilla, medulla, and cortex regions from within a single recurrent stone forming kidney. Results were overlaid between differentially expressed genes found in the patient cohort and in the severely lithogenic kidney to identify common genes.

Overlay of these two RNA-sequencing datasets demonstrated there is impairment of lipid metabolism in renal papilla tissue containing RP linked to downregulation of fatty acid-binding protein (FABP) 4. Immunohistochemistry of human kidney specimens and microarray analysis of renal tissue from a nephrolithiasis mouse model confirmed that FABP4 downregulation is associated with renal stone formation. Furthermore, they discovered that FABP4 deficiency resulted in the development of both renal and urinary crystals in a FABP4 knockout mouse model.

Their study revealed that FABP4 plays an important, previously unrecognized role in kidney stone formation, providing a feasible mechanism to explain the link between nephrolithiasis and metabolic syndrome. They concluded that FABP4 appears to be a key molecule for kidney stone formation and may prove to be a therapeutic target for their prevention.
-end-


Nagoya City University

Related Metabolic Syndrome Articles from Brightsurf:

Metabolic syndrome linked to worse outcomes for COVID-19 patients
Patients hospitalized with COVID-19 who had a combination of high blood pressure, obesity and diabetes were over three times more likely to die from the disease, according to a new Tulane University study published in Diabetes Care.

New study finds that menopause increases risk of metabolic syndrome
Perimenopause is a time when women become more vulnerable to a number of health problems.

Does sarcoponic obesity link to metabolic syndrome? An issue that needs clarification
A systematic review and meta-analysis with the main scope to provide benchmark data on the prevalence of metabolic syndrome (Mets) among individuals with Sarcopenic Obesity (SO), as well as to detect the potential association between the presence of SO and the higher risk of Mets.

Socioeconomics, metabolic syndrome, and osteopenia in postmenopausal women
The increased prevalence of metabolic syndrome and osteoporosis in postmenopausal women has prompted multiple research studies to understand why.

Metabolic syndrome associated with increased risk of blood clot recurrence
People with metabolic syndrome -- a set of conditions including obesity, impaired glucose metabolism, elevated levels of fats and cholesterol in the blood, and high blood pressure - are more likely to experience recurrent blood clots, according to a new study published today in Blood Advances.

Hops compounds help with metabolic syndrome while reducing microbiome diversity
Compounds from hops may combat metabolic syndrome by changing the gut microbiome and altering the metabolism of acids produced in the liver, new research suggests.

Metabolic syndrome: New use for an old drug
The discovery, described in a study by Cosbi and Cimec of the University of Trento published today in Nature Communications, confirms the effectiveness of repurposing, the new frontier of pharmacological research.

Three easy measures to predict metabolic syndrome in elderly
A new study found a surprisingly high rate of metabolic syndrome among individuals aged 60-100 years.

Nanovaccine boosts immunity in sufferers of metabolic syndrome
A new class of biomaterial developed by Cornell researchers for an infectious disease nanovaccine effectively boosted immunity in mice with metabolic disorders linked to gut bacteria - a population that shows resistance to traditional flu and polio vaccines.

Natural sugar defends against metabolic syndrome, in mice
New research, in mice, indicates that a natural sugar called trehalose blocks glucose from the liver and activates a gene that boosts insulin sensitivity, reducing the chance of developing diabetes.

Read More: Metabolic Syndrome News and Metabolic Syndrome Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.