Study suggests men more likely to develop type 2 diabetes if they go through puberty early

March 23, 2020

Boys who enter puberty at an early age are more likely to develop type 2 diabetes as adults than later developing boys, irrespective of their weight in childhood, according to an observational study following more than 30,600 Swedish men born between 1945 and 1961, published in Diabetologia (the journal of the European Association for the Study of Diabetes).

Specifically, researchers found that boys who had their pubertal growth spurt at age 9.3 to 13.4 years (the youngest group) were around twice as likely to develop early type 2 diabetes (aged 57 years or younger), than those who had the growth spurt at the age of 14.8 to 17.9 years (the oldest group), when the data was adjusted for the children's body-mass index (BMI) (see table 3 full paper).

In addition to an increased risk of early type 2 diabetes, boys who went through puberty in the youngest group also had a 27% increased risk of late type 2 diabetes (after age 57 years), not as pronounced as for early type 2 diabetes. The age of 57.2 years was the cut-off point for 'early' and 'late' since it was the median age of developing diabetes in the study, with an equal number of those who developed diabetes doing so both before and after this age. The associations between early puberty and early and late type 2 diabetes were also maintained after adjustment for a range of factors including birth year, country of birth, birthweight, and education level.

An elevated BMI in adulthood is a well-known risk factor for type 2 diabetes. Previous studies have found that boys who are overweight as children, or gain excessive weight during puberty, are more likely to develop type 2 diabetes as adults. In addition, evidence suggests a link between early puberty onset in girls (start of menstruation) and higher diabetes risk, but retrospective studies in boys have been hampered by the lack of easily available markers of puberty. The purpose of this new study was to determine whether puberty timing can be linked to diabetes risk in men, even after adjusting for changes in BMI, using an objective measure of puberty timing.

In this study, Associate Professor Jenny Kindblom and Professor Claes Ohlsson of the University of Gothenburg, Sweden, and colleagues, analysed the health records of 30,697 Swedish men born between 1945 and 1961 who had BMI measured in both childhood (age 8 years) and young adulthood (age 20 years) as part of the BMI Epidemiology Study Gothenburg--a population-based study in Sweden. Timing of puberty was calculated using age at peak height velocity (PHV), the time when boys grow the fastest during their adolescent growth spurt, which occurs around 2 years after entering puberty. Average age at puberty was 14 years.

Participants´ data on height and weight during childhood and adolescence were linked with national registers and followed to the end of 2016 or until they were diagnosed with type 2 diabetes, emigrated, or died. During an average 30.7 years of follow-up (from age 30), 1,851 men were diagnosed with type 2 diabetes, at an average (median) age of 57.2 years.

For each year earlier that the pubertal growth spurt occurred, the risk of developing early diabetes increased by 28%, while the risk of late diabetes rose 13%. These associations were similar after adjusting for BMI at 8 years of age (24% vs 11%).

However, when researchers adjusted the analyses for BMI after puberty (i.e. at 20 years of age), the associations were attenuated and the significant association with late type 2 diabetes was lost. Importantly, early puberty was still significantly associated with early type 2 diabetes, also after adjustment for BMI at 20 years, with a 16% increased risk of early diabetes per year earlier that puberty took place. In contrast, a pubertal growth spurt at a late age (after 15 years of age, the latest 20%) was associated with a 30% reduced risk of developing early diabetes (table 5) when compared with those going through puberty at average age (the 'middle' 20% of men who went through puberty at 13.8 to 14.3 years of age).

Men who had early pubertal growth spurt were also more likely to require insulin treatment if they went on to develop type 2 diabetes (a 25% increased risk of developing insulin-dependent type 2 diabetes for each year earlier of going through puberty).

"Our findings suggest that early puberty could be a novel independent risk factor for type 2 diabetes in men", says Assoc Prof Kindblom. "Given the apparent higher risk among boys who start puberty before the average age of 14 years, we estimate that 15% fewer men who were diagnosed during the study would have developed type 2 diabetes had they not started puberty early."

She adds: "Although the mechanisms for the link between early puberty and higher risk of type 2 diabetes are unclear, it is possible that starting puberty at an earlier age may lead to the accumulation of excess abdominal fat, which in turn increases cardiometabolic risk factors such as high blood pressure, diabetes, and abnormal lipid levels."

She concludes: "These findings strengthen the concept that early puberty is part of an adverse trajectory during childhood and adolescence, and that a high BMI both before and after puberty contributes. A continuous monitoring of height and weight development during not only childhood but also adolescence is of importance and might help identify individuals with increased risk."

The authors acknowledge that their findings show observational associations, and do not prove that early puberty causes the increase in type 2 diabetes. They note several limitations of the study including that it did not include data on BMI in later life or control for family history of diabetes and smoking, which are known to increase the risk of diabetes. They also point out that most participants were white, which could limit the generalisability of the findings to other ethnicities with a higher prevalence of type 2 diabetes.


Related Diabetes Articles from Brightsurf:

New diabetes medication reduced heart event risk in those with diabetes and kidney disease
Sotagliflozin - a type of medication known as an SGLT2 inhibitor primarily prescribed for Type 2 diabetes - reduces the risk of adverse cardiovascular events for patients with diabetes and kidney disease.

Diabetes drug boosts survival in patients with type 2 diabetes and COVID-19 pneumonia
Sitagliptin, a drug to lower blood sugar in type 2 diabetes, also improves survival in diabetic patients hospitalized with COVID-19, suggests a multicenter observational study in Italy.

Making sense of diabetes
Throughout her 38-year nursing career, Laurel Despins has progressed from a bedside nurse to a clinical nurse specialist and has worked in medical, surgical and cardiac intensive care units.

Helping teens with type 1 diabetes improve diabetes control with MyDiaText
Adolescence is a difficult period of development, made more complex for those with Type 1 diabetes mellitus (T1DM).

Diabetes-in-a-dish model uncovers new insights into the cause of type 2 diabetes
Researchers have developed a novel 'disease-in-a-dish' model to study the basic molecular factors that lead to the development of type 2 diabetes, uncovering the potential existence of major signaling defects both inside and outside of the classical insulin signaling cascade, and providing new perspectives on the mechanisms behind insulin resistance in type 2 diabetes and possibly opportunities for the development of novel therapeutics for the disease.

Tele-diabetes to manage new-onset diabetes during COVID-19 pandemic
Two new case studies highlight the use of tele-diabetes to manage new-onset type 1 diabetes in an adult and an infant during the COVID-19 pandemic.

Genetic profile may predict type 2 diabetes risk among women with gestational diabetes
Women who go on to develop type 2 diabetes after having gestational, or pregnancy-related, diabetes are more likely to have particular genetic profiles, suggests an analysis by researchers at the National Institutes of Health and other institutions.

Maternal gestational diabetes linked to diabetes in children
Children and youth of mothers who had gestational diabetes during pregnancy are at increased risk of diabetes themselves, according to new research published in CMAJ (Canadian Medical Association Journal).

Two diabetes medications don't slow progression of type 2 diabetes in youth
In youth with impaired glucose tolerance or recent-onset type 2 diabetes, neither initial treatment with long-acting insulin followed by the drug metformin, nor metformin alone preserved the body's ability to make insulin, according to results published online June 25 in Diabetes Care.

People with diabetes visit the dentist less frequently despite link between diabetes, oral health
Adults with diabetes are less likely to visit the dentist than people with prediabetes or without diabetes, finds a new study led by researchers at NYU Rory Meyers College of Nursing and East Carolina University's Brody School of Medicine.

Read More: Diabetes News and Diabetes Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to