Study Shows Gum Disease Increases Risk Of Future Heart Disease

March 23, 1997

ORLANDO, FLA. -- Persons with gum disease are at high risk of developing heart disease in the future, particularly if they also are diabetic, researchers in the University at Buffalo School of Dental Medicine have found.

Results of the study, conducted among Native Americans from the Gila River Indian community in Mesa, Ariz., 40 percent of whom have diabetes, showed that periodontal disease was a stronger risk factor in this population than other conditions traditionally associated with heart disease risk, including hypertension, high cholesterol, age and gender.

Robert J. Genco, SUNY Distinguished Professor and chair of the UB Department of Oral Biology, reported the results here today (Sunday, March 23) at the annual meeting of the International Association for Dental Research.

"We have always suspected that periodontal disease was a true risk factor for cardiovascular disease, but our studies have been confounded by the presence of smoking," Genco said.

"Smoking is rare in this community of Pima Indians, so it was not a factor," he added. "We found a powerful association between the existence of periodontal disease at the study baseline and the development of cardiovascular disease in the succeeding 10 years." Diabetes was the only factor that showed a stronger association.

"There are many reasons to treat periodontal disease," Genco said. "This is a very good one."

New dental research being conducted at UB and other institutions is showing a strong relationship between conditions in the oral cavity and many systemic diseases. In this case, bacteria present in periodontal disease is thought to be the culprit, Genco said.

"Oral bacteria enter the bloodstream via small ulcers in the gum tissue. These bacteria causes platelets to aggregate and form clumps, or thrombi. These clumps accumulate on damaged tissue, such as lesions in the blood vessel or a heart-valve replacement, which

represents a damaged area in the heart. The transplanted bacteria can cause the valve to become infected, and the accumulated clumps can block blood vessels.

"We¹ve known for some time that oral bacteria can infect damaged hearts and that certain oral bacteria cause platelets to aggregate," Genco said. "We just recently put these findings together as a possible explanation of how bacteria that cause periodontal disease can also increase the risk for heart disease."

Genco has been following this population of American Indians since 1982, first as a consultant to the National Institutes of Health when severe periodontal disease was found among them, and then for a 10-year study of periodontal disease in diabetics. The new findings on the relationship between periodontal disease and cardiovascular disease are part of that study.

Participating in the research were scientists from the UB Periodontal Disease Research Center, the University of Michigan School of Dentistry and the division of the National Institute of Diabetes and Digestive and Kidney Diseases in Phoenix, Ariz.

The research was supported by a grant from the U.S. Public Health Service
-end-


University at Buffalo

Related Diabetes Articles from Brightsurf:

New diabetes medication reduced heart event risk in those with diabetes and kidney disease
Sotagliflozin - a type of medication known as an SGLT2 inhibitor primarily prescribed for Type 2 diabetes - reduces the risk of adverse cardiovascular events for patients with diabetes and kidney disease.

Diabetes drug boosts survival in patients with type 2 diabetes and COVID-19 pneumonia
Sitagliptin, a drug to lower blood sugar in type 2 diabetes, also improves survival in diabetic patients hospitalized with COVID-19, suggests a multicenter observational study in Italy.

Making sense of diabetes
Throughout her 38-year nursing career, Laurel Despins has progressed from a bedside nurse to a clinical nurse specialist and has worked in medical, surgical and cardiac intensive care units.

Helping teens with type 1 diabetes improve diabetes control with MyDiaText
Adolescence is a difficult period of development, made more complex for those with Type 1 diabetes mellitus (T1DM).

Diabetes-in-a-dish model uncovers new insights into the cause of type 2 diabetes
Researchers have developed a novel 'disease-in-a-dish' model to study the basic molecular factors that lead to the development of type 2 diabetes, uncovering the potential existence of major signaling defects both inside and outside of the classical insulin signaling cascade, and providing new perspectives on the mechanisms behind insulin resistance in type 2 diabetes and possibly opportunities for the development of novel therapeutics for the disease.

Tele-diabetes to manage new-onset diabetes during COVID-19 pandemic
Two new case studies highlight the use of tele-diabetes to manage new-onset type 1 diabetes in an adult and an infant during the COVID-19 pandemic.

Genetic profile may predict type 2 diabetes risk among women with gestational diabetes
Women who go on to develop type 2 diabetes after having gestational, or pregnancy-related, diabetes are more likely to have particular genetic profiles, suggests an analysis by researchers at the National Institutes of Health and other institutions.

Maternal gestational diabetes linked to diabetes in children
Children and youth of mothers who had gestational diabetes during pregnancy are at increased risk of diabetes themselves, according to new research published in CMAJ (Canadian Medical Association Journal).

Two diabetes medications don't slow progression of type 2 diabetes in youth
In youth with impaired glucose tolerance or recent-onset type 2 diabetes, neither initial treatment with long-acting insulin followed by the drug metformin, nor metformin alone preserved the body's ability to make insulin, according to results published online June 25 in Diabetes Care.

People with diabetes visit the dentist less frequently despite link between diabetes, oral health
Adults with diabetes are less likely to visit the dentist than people with prediabetes or without diabetes, finds a new study led by researchers at NYU Rory Meyers College of Nursing and East Carolina University's Brody School of Medicine.

Read More: Diabetes News and Diabetes Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.