Study Suggests Triglyceride Levels May Be Considered An Independent Risk Factor For Heart Attack In Some People

March 23, 1998

DALLAS, March 24 -- Major changeable risk factors for heart attack include smoking, high blood cholesterol, high blood pressure and physical inactivity. According to a study published in today's Circulation: Journal of the American Heart Association, high blood levels of the fat triglyceride may need to be added to the list.

Researchers in Denmark say that in middle-aged and older white men, a high level of triglycerides -- the chemical form in which most fat exists in food as well as in the body -- may mean a higher risk for heart attack. Therefore, the scientists say, high blood levels of triglycerides should be considered an independent risk factor for heart attack.

In the study, men with the highest levels of triglycerides were more than twice as likely to have a heart attack when compared to those with the lowest triglyceride levels.

An excess amount of triglycerides in blood is called hypertriglyceridemia, which is linked to the occurrence of heart disease in some people. Elevated triglycerides may be a consequence of other diseases, such as diabetes. Like cholesterol, triglyceride levels can be detected with a blood test.

High levels of triglycerides can influence the size, density distribution and composition of LDL (low-density lipoprotein) cholesterol -- the "bad" cholesterol -- leading to smaller, denser LDL particles, which are more likely to promote the obstructions in the blood vessels that trigger heart attack.

"So far our study appears to provide the strongest evidence that higher triglyceride levels are related to increased risk of ischemic heart disease in men independent of other major risk factors such as total cholesterol and HDL (high-density lipoprotein) cholesterol," says Jorgen Jeppesen, M.D., of the Epidemiological Research Unit, Copenhagen University Hospital, Copenhagen, Denmark.

In an editorial, former American Heart Association President Antonio Gotto, M.D. says that while additional research is necessary to determine whether lowering triglyceride levels can reduce heart attack deaths, the findings make a compelling argument for measuring triglyceride levels as part of an evaluation to determine an individual's risk for heart disease.

"The growing attention to high levels of triglycerides and increased coronary heart disease risk is encouraging to veterans of the 'triglyceride wars,'" says Gotto, dean of the Cornell University Medical School, New York City. "It's also in agreement with another trend in heart attack risk management, namely, the concept of global risk assessment."

Triglycerides are the form in which fat exists in meats, cheese, fish, nuts, vegetable oils, and the greasy layer on the surface of soup stocks or in a pan in which bacon has been fried. In a healthy person, triglycerides and other fatty substances are normally moved into the liver and into storage cells to provide energy for later use.

People with less than 200 milligrams of triglycerides per deciliter (mg/dL) of blood are considered to have normal triglyceride levels. Between 200 and 400 mg/dL is borderline high; between 400 and 1,000 mg/dL is a high triglyceride level; and greater than 1,000 mg/dL is considered very high triglycerides.

"A very interesting finding in our study was that people with triglyceride levels as low as 142 mg/dL were clearly at a higher risk of heart disease," says Jeppesen. "We believe this is of substantial clinical interest since a triglyceride level of below 200 mg/dL is usually considered 'safe.'"

In the study of 2,906 white men who were initially free of any heart disease, researchers found that during an eight-year follow-up period, 229 men had a heart attack. By examining that group of men, the scientists found that heart attack risk increased in those with the highest levels of fasting triglycerides -- measurements taken after 12 hours of fasting prior to the test.

"When the triglyceride levels were measured by the amounts of HDL cholesterol in the blood, a clearer picture emerged," says Jeppesen. "Even those who had high HDL levels, which are thought to protect against heart attack, were still found to be at higher risk for heart disease because of their triglyceride levels."

The American Heart Association says that changes in life habits -- cutting down on calories, reducing saturated fat and cholesterol in the diet, reduce alcohol intake and begin a regular exercise program -- can help in the treatment of hypertriglyceridemia.

Co-authors are Hans Ole Hein, M.D.; Poul Suadicani, D.D. and Finn Gyntelberg, M.D.
-end-
NR 98-4877 (Circ/Jeppesen)

Media advisory: Dr. Jeppesen can be reached by phone at 011 45 35 31 60 66 or 011 45 43 71 80 10 or by fax at 011 45 35 31 60 70. (Please do not publish numbers.)
-end-


American Heart Association

Related Heart Disease Articles from Brightsurf:

Cellular pathway of genetic heart disease similar to neurodegenerative disease
Research on a genetic heart disease has uncovered a new and unexpected mechanism for heart failure.

Mechanism linking gum disease to heart disease, other inflammatory conditions discovered
The link between periodontal (gum) disease and other inflammatory conditions such as heart disease and diabetes has long been established, but the mechanism behind that association has, until now, remained a mystery.

New 'atlas' of human heart cells first step toward precision treatments for heart disease
Scientists have for the first time documented all of the different cell types and genes expressed in the healthy human heart, in research published in the journal Nature.

With a heavy heart: How men and women develop heart disease differently
A new study by researchers from McGill University has uncovered that minerals causing aortic heart valve blockage in men and women are different, a discovery that could change how heart disease is diagnosed and treated.

Heart-healthy diets are naturally low in dietary cholesterol and can help to reduce the risk of heart disease and stroke
Eating a heart-healthy dietary pattern rich in vegetables, fruits, whole grains, low-fat dairy products, poultry, fish, legumes, vegetable oils and nuts, which is also limits salt, red and processed meats, refined-carbohydrates and added sugars, is relatively low in dietary cholesterol and supports healthy levels of artery-clogging LDL cholesterol.

Pacemakers can improve heart function in patients with chemotherapy-induced heart disease
Research has shown that treating chemotherapy-induced cardiomyopathy with commercially available cardiac resynchronization therapy (CRT) delivered through a surgically implanted defibrillator or pacemaker can significantly improve patient outcomes.

Arsenic in drinking water may change heart structure raising risk of heart disease
Drinking water that is contaminated with arsenic may lead to thickening of the heart's main pumping chamber in young adults, according to a new study by researchers at Columbia University Mailman School of Public Health.

New health calculator can help predict heart disease risk, estimate heart age
A new online health calculator can help people determine their risk of heart disease, as well as their heart age, accounting for sociodemographic factors such as ethnicity, sense of belonging and education, as well as health status and lifestyle behaviors.

Wide variation in rate of death between VA hospitals for patients with heart disease, heart failure
Death rates for veterans with ischemic heart disease and chronic heart failure varied widely across the Veterans Affairs (VA) health care system from 2010 to 2014, which could suggest differences in the quality of cardiovascular health care provided by VA medical centers.

Heart failure: The Alzheimer's disease of the heart?
Similar to how protein clumps build up in the brain in people with some neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, protein clumps appear to accumulate in the diseased hearts of mice and people with heart failure, according to a team led by Johns Hopkins University researchers.

Read More: Heart Disease News and Heart Disease Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.