Nav: Home

Most individuals harbor B cells sensitive to HIV-fighting immunogen

March 24, 2016

Researchers have identified a relatively potent immunogen that could be harnessed to induce the immune system to target HIV. Recently, evidence suggests that using immunogens that prompt B cells to produce broadly neutralizing antibodies (bnAbs) may be a viable HIV vaccine strategy. In previous work, Joseph Jardine and colleagues demonstrated this possibility by using an immunogen that could bind to B cells engineered to express VRC01 class bnAbs (a class of highly broad and potent bnAbs) as well as their germline precursors. Yet questions remain as to whether immunogens can bind to naïve human B cells and whether enough naïve B cells are present in various individuals to make this strategy viable. Here, by analyzing a library of immunogens and comparing their potency, Jardine et al. identify an immunogen, eOD-GT8, which demonstrated extraordinary binding affinity for naïve B cells - it outperforms their previously identified immunogen by a factor of 2100. Next, they analyzed millions of B cells from 15 people who tested negative for HIV, to gain a better understanding of the prevalence of B cells that could interact with eOD-GT8. Their analysis indicates that about 96% of humans harbor such B cells, suggesting that eOD-GT8 is a promising candidate for future vaccines.
-end-


American Association for the Advancement of Science

Related Immune System Articles:

The immune system may explain skepticism towards immigrants
There is a strong correlation between our fear of infection and our skepticism towards immigrants.
New insights on how pathogens escape the immune system
The bacterium Salmonella enterica causes gastroenteritis in humans and is one of the leading causes of food-borne infectious diseases.
Understanding how HIV evades the immune system
Monash University (Australia) and Cardiff University (UK) researchers have come a step further in understanding how the human immunodeficiency virus (HIV) evades the immune system.
Carbs during workouts help immune system recovery
Eating carbohydrates during intense exercise helps to minimise exercise-induced immune disturbances and can aid the body's recovery, QUT research has found.
A new model for activation of the immune system
By studying a large protein (the C1 protein) with X-rays and electron microscopy, researchers from Aarhus University in Denmark have established a new model for how an important part of the innate immune system is activated.
Guards of the human immune system unraveled
Dendritic cells represent an important component of the immune system: they recognize and engulf invaders, which subsequently triggers a pathogen-specific immune response.
How our immune system targets TB
Researchers have seen, for the very first time, how the human immune system recognizes tuberculosis (TB).
How a fungus inhibits the immune system of plants
A newly discovered protein from a fungus is able to suppress the innate immune system of plants.
A new view of the immune system
Pathogen epitopes are fragments of bacterial or viral proteins. Nearly a third of all existing human epitopes consist of two different fragments.
TB tricks the body's immune system to allow it to spread
Tuberculosis tricks the immune system into attacking the body's lung tissue so the bacteria are allowed to spread to other people, new research from the University of Southampton suggests.

Related Immune System Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Anthropomorphic
Do animals grieve? Do they have language or consciousness? For a long time, scientists resisted the urge to look for human qualities in animals. This hour, TED speakers explore how that is changing. Guests include biological anthropologist Barbara King, dolphin researcher Denise Herzing, primatologist Frans de Waal, and ecologist Carl Safina.
Now Playing: Science for the People

#SB2 2019 Science Birthday Minisode: Mary Golda Ross
Our second annual Science Birthday is here, and this year we celebrate the wonderful Mary Golda Ross, born 9 August 1908. She died in 2008 at age 99, but left a lasting mark on the science of rocketry and space exploration as an early woman in engineering, and one of the first Native Americans in engineering. Join Rachelle and Bethany for this very special birthday minisode celebrating Mary and her achievements. Thanks to our Patreons who make this show possible! Read more about Mary G. Ross: Interview with Mary Ross on Lash Publications International, by Laurel Sheppard Meet Mary Golda...