Nav: Home

World TB Day: Medical trial to tackle tuberculosis in South Africa

March 24, 2016

Researchers from the University of Liverpool have been awarded a grant worth more than £400,000 to conduct a medical trial focused on controlling tuberculosis (TB) epidemics in South Africa.

In South Africa, and other countries where HIV is common, accelerated action is required to control tuberculosis epidemics. Previous studies in the region have shown that people living in households where individuals have been diagnosed with TB have high rates of undiagnosed disease and Human Immunodeficiency Virus (HIV), with difficulties accessing health care.

Novel approach

A team of investigators from the University's Institute of Psychology, Health and Society, in collaboration with the University of Witwatersrand in South Africa, the London School of Hygiene and Tropical Medicine, and the Johns Hopkins Bloomberg School of Public Health (USA), have been awarded a prestigious Medical Research Council (MRC) Newton Fund Grant totalling £401,622 to conduct a trial in two provinces of South Africa (North West Province and Limpopo Province).

The team will investigate a novel approach comprising of intensified household tracing and screening for TB and HIV using new rapid molecular technologies that can provide correct and timely diagnosis of infection, and high impact anti-tuberculosis prevention therapy. This approach will also provide supported access to care and treatment for household members diagnosed with TB and HIV.

Leading cause of death

Dr Peter MacPherson, Department of Public Health and Policy, Institute of Psychology, Health and Society, said: "South Africa has an extremely serious generalised HIV epidemic. It is estimated that 6.4 million people were living with HIV in 2015, the highest number of any country in the world. HIV has caused theTB epidemic in South Africa to rapidly escalate, which has had a severe effect on both individuals and communities.

"TB is the single leading cause of death in South Africa, and efforts to address it are complicated by a range of factors, including persistent poverty, poor nutrition, high rates of co-infection with HIV, rising rates of diabetes, and widespread antibiotic resistance. The new approach we are taking in this trial will help improve understanding of how best to fight HIV and TB epidemics."

The trial is due to commence in May 2016 and run for two-and-a-half years.

The MRC's Newton Fund is a UK Government initiative intended to strengthen research and innovation partnerships between the UK and emerging knowledge economies.

University of Liverpool

Related Hiv Articles:

Defective HIV proviruses reduce effective immune system response, interfere with HIV cure
A new study finds defective HIV proviruses, long thought to be harmless, produce viral proteins and distract the immune system from killing intact proviruses needed to reduce the HIV reservoir and cure HIV.
1 in 7 people living with HIV in the EU/EEA are not aware of their HIV status
Almost 30,000 newly diagnosed HIV infections were reported by the 31 European Union and European Economic Area (EU/EEA) countries in 2015, according to data published today by ECDC and the WHO Regional Office for Europe.
Smoking may shorten the lifespan of people living with HIV more than HIV itself
A new study led by researchers at Massachusetts General Hospital finds that cigarette smoking substantially reduces the lifespan of people living with HIV in the US, potentially even more than HIV itself.
For smokers with HIV, smoking may now be more harmful than HIV itself
HIV-positive individuals who smoke cigarettes may be more likely to die from smoking-related disease than the infection itself, according to a new study published in the Journal of Infectious Diseases.
Patients diagnosed late with HIV infection are more likely to transmit HIV to others
An estimated 1.2 million people live with HIV in the United States, with nearly 13 percent being unaware of their infection.
The Lancet HIV: New HIV infections stagnating at 2.5 million a year worldwide
A major new analysis from the Global Burden of Disease 2015 study, published today in The Lancet HIV journal, reveals that although deaths from HIV/AIDS have been steadily declining from a peak in 2005, 2.5 million people worldwide became newly infected with HIV in 2015, a number that hasn't changed substantially in the past 10 years.
NIH scientists discover that defective HIV DNA can encode HIV-related proteins
Investigators from the National Institutes of Health have discovered that cells from HIV-infected people whose virus is suppressed with treatment harbor defective HIV DNA that can nevertheless be transcribed into a template for producing HIV-related proteins.
Study examines risk of HIV transmission from condomless sex with virologically suppressed HIV infection
Among nearly 900 serodifferent (one partner is HIV-positive, one is HIV-negative) heterosexual and men who have sex with men couples in which the HIV-positive partner was using suppressive antiretroviral therapy and who reported condomless sex, during a median follow-up of 1.3 years per couple, there were no documented cases of within-couple HIV transmission, according to a study appearing in the July 12 issue of JAMA, an HIV/AIDS theme issue.
HIV vaccine design should adapt as HIV virus mutates
Researchers from UAB, Emory and Microsoft demonstrate that HIV has evolved to be pre-adapted to the immune response, worsening clinical outcomes in newly infected patients.
Charlie Sheen's HIV disclosure may reinvigorate awareness, prevention of HIV
Actor Charlie Sheen's public disclosure in November 2015 that he has the human immunodeficiency virus (HIV) corresponded with the greatest number of HIV-related Google searches ever recorded in the United States, according to an article published online by JAMA Internal Medicine.

Related Hiv Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Do animals grieve? Do they have language or consciousness? For a long time, scientists resisted the urge to look for human qualities in animals. This hour, TED speakers explore how that is changing. Guests include biological anthropologist Barbara King, dolphin researcher Denise Herzing, primatologist Frans de Waal, and ecologist Carl Safina.
Now Playing: Science for the People

#SB2 2019 Science Birthday Minisode: Mary Golda Ross
Our second annual Science Birthday is here, and this year we celebrate the wonderful Mary Golda Ross, born 9 August 1908. She died in 2008 at age 99, but left a lasting mark on the science of rocketry and space exploration as an early woman in engineering, and one of the first Native Americans in engineering. Join Rachelle and Bethany for this very special birthday minisode celebrating Mary and her achievements. Thanks to our Patreons who make this show possible! Read more about Mary G. Ross: Interview with Mary Ross on Lash Publications International, by Laurel Sheppard Meet Mary Golda...