Nav: Home

Curcumin may help overcome drug-resistant tuberculosis

March 24, 2016

New research indicates that curcumin--a substance in turmeric that is best known as one of the main components of curry powder--may help fight drug-resistant tuberculosis. In Asia, turmeric is used to treat many health conditions and it has anti-inflammatory, antioxidant, and perhaps even anticancer properties.

Investigators found that by stimulating human immune cells called macrophages, curcumin was able to successfully remove Mycobacterium tuberculosis, the causative bacterium of tuberculosis, from experimentally infected cells in culture. The process relied on inhibiting the activation of a cellular molecule called nuclear factor-kappa B.

The ability of curcumin to modulate the immune response to Mycobacterium tuberculosis points to a potential new tuberculosis treatment that would be less prone to the development of drug resistance.

"Our study has provided basic evidence that curcumin protects against Mycobacterium tuberculosis infection in human cells," said Dr. Xiyuan Bai, lead author of the Respirology study. "The protective role of curcumin to fight drug-resistant tuberculosis still needs confirmation, but if validated, curcumin may become a novel treatment to modulate the host immune response to overcome drug-resistant tuberculosis."
-end-
About Wiley

Wiley is a global provider of knowledge and knowledge-enabled services that improve outcomes in areas of research, professional practice and education. Through the Research segment, the Company provides digital and print scientific, technical, medical, and scholarly journals, reference works, books, database services, and advertising. The Professional Development segment provides digital and print books, online assessment and training services, and test prep and certification. In Education, Wiley provides education solutions including online program management services for higher education institutions and course management tools for instructors and students, as well as print and digital content. The Company's website can be accessed at http://www.wiley.com.

Wiley

Related Tuberculosis Articles:

Old target, new mechanism for overcoming tuberculosis resistance
In strains of tuberculosis that have developed drug resistance mutations, researchers have identified a secondary pathway that can be activated to reinstate drug sensitivity.
Researchers use tiny 3-D spheres to combat tuberculosis
Researchers at the University of Southampton have developed a new 3-D system to study human infection in the laboratory.
How the tuberculosis vaccine may protect against other diseases
The tuberculosis vaccine is well known to help protect against other infectious diseases, as well as cancer, but the exact mechanisms have not been clear.
Tuberculosis bacteria find their ecological niche
An international team of researchers have isolated and analyzed genetically tuberculosis bacteria from several thousand patients from over a hundred countries.
Tuberculosis and HIV co-infection
The HIV virus increases the potency of the tuberculosis bacterium (Mtb) by affecting a central function of the immune system.
Scientists explain why Russian tuberculosis is the most infectious
Scientists conducted a large-scale analysis of the proteins and genomes of mycobacterium tuberculosis strains that are common in Russia and countries of the former Soviet Union and found features that provide a possible explanation for their epidemiological success.
Tuberculosis elimination at stake
New data released by the European Centre for Disease Prevention and Control and WHO/Europe show that an estimated 340,000 Europeans developed tuberculosis in 2014, corresponding to a rate of 37 cases per 100,000 population.
Curcumin may help overcome drug-resistant tuberculosis
New research indicates that curcumin -- a substance in turmeric that is best known as one of the main components of curry powder -- may help fight drug-resistant tuberculosis.
Stopping tuberculosis requires new strategy
Unless there is a major shift in the way the world fights tuberculosis -- from a reliance on biomedical solutions to an approach that combines biomedical interventions with social actions -- the epidemic and drug resistance will worsen, say researchers at Harvard T.H.
Tulane researchers working on new tuberculosis vaccine
Researchers at the Tulane National Primate Research Center are leading efforts to find a new vaccine for tuberculosis, one of the world's deadliest diseases.

Related Tuberculosis Reading:

Catching Breath: The Making and Unmaking of Tuberculosis (Bloomsbury Sigma)
by Kathryn Lougheed (Author)

Tuberculosis and Nontuberculous Mycobacterial Infections
by David Schlossberg (Editor)

Invincible Microbe: Tuberculosis and the Never-Ending Search for a Cure
by Jim Murphy (Author), Alison Blank (Author)

The Forgotten Plague: How the Battle Against Tuberculosis Was Won - And Lost
by Frank Ryan (Author)

Handbook of Tuberculosis
by Jacques H. Grosset (Editor), Richard E. Chaisson (Editor)

Spitting Blood: The history of tuberculosis
by Helen Bynum (Author)

Well Diary...I Have Tuberculosis: Researching a Teenager's 1918 Sanatorium Experience
by Shirley Morgan (Author)

Clinical Tuberculosis: A Practical Handbook
by Peter D. O. Davies (Editor)

Tuberculosis and the Victorian Literary Imagination (Cambridge Studies in Nineteenth-Century Literature and Culture)
by Katherine Byrne (Author)

The White Plague: Tuberculosis, Man and Society
by Jean Dubos (Author), Barbara Gutmann Rosenkrantz (Introduction), David Mechanic (Introduction)

Best Science Podcasts 2018

We have hand picked the best science podcasts for 2018. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Hacking The Law
We have a vision of justice as blind, impartial, and fair — but in reality, the law often fails those who need it most. This hour, TED speakers explore radical ways to change the legal system. Guests include lawyer and social justice advocate Robin Steinberg, animal rights lawyer Steven Wise, political activist Brett Hennig, and lawyer and social entrepreneur Vivek Maru.
Now Playing: Science for the People

#495 Earth Science in Space
Some worlds are made of sand. Some are made of water. Some are even made of salt. In science fiction and fantasy, planet can be made of whatever you want. But what does that mean for how the planets themselves work? When in doubt, throw an asteroid at it. This is a live show recorded at the 2018 Dragon Con in Atlanta Georgia. Featuring Travor Valle, Mika McKinnon, David Moscato, Scott Harris, and moderated by our own Bethany Brookshire. Note: The sound isn't as good as we'd hoped but we love the guests and the conversation and we wanted to...