Nav: Home

Development of a solid material capable of slowly releasing H2S and NO

March 24, 2020

NIMS has developed a solid material capable of slowly releasing hydrogen sulfide (H2S) and nitric oxide (NO) when exposed to air. These gases can induce physiologically favorable effects at low concentrations (e.g., reducing inflammation and expanding blood vessels). However, their medical use has been limited due to difficulties in storing them and regulating their concentration. This material can release these gases safely and conveniently and will facilitate their medical use.

Although H2S and NO are toxic at high concentrations, they can generate beneficial physiological effects when used at low concentrations, such as anti-oxidation, reducing inflammation, expanding blood vessels and regulating insulin secretion. Human bodies produce these gases in small amounts to regulate various physiological functions. Medical use of these gases has been drawing a great deal of interest in recent years. For example, a low concentration of NO can be administered by inhalation to patients with severe respiratory failure (e.g., newborns with persistent pulmonary hypertension and acute respiratory distress syndrome) to expand their pulmonary vessels, thereby improving their symptoms. In addition, hot springs containing H2S have long been known to have positive effects on the skin and cardiovascular system, making H2S a potentially promising agent in the types of medicine dedicated to extending healthy life spans. However, the use of these gases has been accompanied by safety concerns and requires a large system equipped with high-pressure gas tanks. To address these issues, efforts have been made to develop solid materials capable of safely and easily storing medically useful gases and releasing them at regulated concentration in the hope of facilitating their medical use.

The NIMS research team recently developed a solid material using an inorganic compound called a layered double hydroxide which can slowly release H2S or NO at a desirable concentration when exposed to air. This material is primarily composed of layers of two-dimensional hydroxide nanosheets that contain magnesium (Mg) and aluminum (Al). This research team previously discovered that carbonate ions in the interlayer space of nanosheet layers are actively exchanged with atmospheric carbon dioxide. In this project, the team intercalated gas-source ions to the interlayer spaces and allowed them to interact with atmospheric carbon dioxide and water vapor, yielding H2S or NO gas. The team then adjusted the Mg/Al ratio in the nanosheets, thereby modifying the size of the gap between them. Different gap sizes enabled H2S or NO gas to be released stably at an intended concentration. The team also succeeded in fabricating a portable NO inhaler prototype capable of operating without a power source. This safe material composed of relatively inexpensive and nontoxic ingredients, including Mg and Al, can be kept in good condition by storing it in a gas impermeable bag. This material can be used easily by exposing it to air in a manner similar to using disposable hand warmers.

Through future study, the team is hoping to develop new drugs and medical devices incorporating this material. The use of such products may enable the provision of new health services and emergency medical services, such as making NO inhalation technologies available at home, at various destinations and in developing countries. Moreover, the material structure the team have developed may be applied to the synthesis of new materials capable of releasing other types of functional gases.
This research project was carried out by Shinsuke Ishihara (Senior Researcher, International Center for Materials Nanoarchitectonics (MANA), NIMS) and Nobuo Iyi (NIMS Special Researcher, MANA, NIMS). This research was published in Nature Communications, an open access scientific journal, at 10:00 am on January 23, 2020, GMT (7:00 pm on January 23, Japan Time).


(Regarding this research)

Shinsuke Ishihara
Senior Researcher,
Frontier Molecules Group,
Nano-Materials Field,
International Center for Materials Nanoarchitectonics (MANA),
National Institute for Materials Science (NIMS)
Tel: +81-29-860-4602
(Please change "=" to "@")

Nobuo Iyi
NIMS Special Researcher,
Soft Chemistry Group,
Nano-Materials Field,
International Center for Materials Nanoarchitectonics (MANA),
National Institute for Materials Science (NIMS)
Tel: +81-29-860-4357
(Please change "=" to "@")

(General information)

Public Relations Office
National Institute for Materials Science
Tel: +81-29-859-2026, Fax: +81-29-859-2017
(Please change "=" to "@")

National Institute for Materials Science, Japan

Related Concentration Articles:

Anthropogenic CO2 increase is unprecedented
Even in earlier warm periods there were pulse-like releases of CO2 to the atmosphere.
Paper: Industry concentration contributes to job quality erosion, wage stagnation
Dominant firms in concentrated industries can play a role in job quality erosion and wage stagnation for U.S. workers, says new research co-written by U. of I. labor and employment relations professor Richard Benton and U. of I. graduate student Ki-Jung Kim.
Oncotarget: Correction of NSE concentration improves diagnostic accuracy in lung cancer
Oncotarget Volume 11, Issue 27 published ''Correction of the NSE concentration in hemolyzed serum samples improves its diagnostic accuracy in small-cell lung cancer'' by Genet et al. which reported that this study aimed to develop a hemolysis correction equation and evaluate its role in small-cell lung cancer (SCLC) diagnostics.
Putting zinc on bread wheat leaves
Applying zinc to the leaves of bread wheat can increase wheat grain zinc concentrations and improve its nutritional content.
Higher concentration of metal in Moon's craters provides new insights to its origin
But new research suggests the Moon's subsurface is more metal-rich than previously thought.
Dimethylsulfoniopropionate concentration in coral reef invertebrates
New research highlights the effect of benthic assemblages on the sulfur metabolism of coral and giant clam species.
NIH study finds lower concentration of PrEP drug in pregnant young women
Among African adolescent girls and young women who took HIV pre-exposure prophylaxis (PrEP) daily, levels of the PrEP drug tenofovir were more than 30% lower in those who were pregnant than in those who had recently given birth.
Areas near concentration camps give more electoral support to the far right
The study, which focused on the federal elections in Germany held in 2013 and 2017, involved Toni Rodon, professor at the Department of Political and Social Sciences at UPF, together with researchers from the London School of Economics and Political Science.
OU study finds the fingerprint of paddy rice in atmospheric methane concentration dynamics
A University of Oklahoma-led study shows that paddy rice (both area and plant growth) is significantly related to the spatial-temporal dynamics of atmospheric methane concentration in monsoon Asia, where 87% of paddy rice fields are situated in the world.
A Matter of concentration
Researchers are studying how proteins regulate the stem cells of plants.
More Concentration News and Concentration Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Sound And Silence
Sound surrounds us, from cacophony even to silence. But depending on how we hear, the world can be a different auditory experience for each of us. This hour, TED speakers explore the science of sound. Guests on the show include NPR All Things Considered host Mary Louise Kelly, neuroscientist Jim Hudspeth, writer Rebecca Knill, and sound designer Dallas Taylor.
Now Playing: Science for the People

#576 Science Communication in Creative Places
When you think of science communication, you might think of TED talks or museum talks or video talks, or... people giving lectures. It's a lot of people talking. But there's more to sci comm than that. This week host Bethany Brookshire talks to three people who have looked at science communication in places you might not expect it. We'll speak with Mauna Dasari, a graduate student at Notre Dame, about making mammals into a March Madness match. We'll talk with Sarah Garner, director of the Pathologists Assistant Program at Tulane University School of Medicine, who takes pathology instruction out of...
Now Playing: Radiolab

Kittens Kick The Giggly Blue Robot All Summer
With the recent passing of Ruth Bader Ginsburg, there's been a lot of debate about how much power the Supreme Court should really have. We think of the Supreme Court justices as all-powerful beings, issuing momentous rulings from on high. But they haven't always been so, you know, supreme. On this episode, we go all the way back to the case that, in a lot of ways, started it all.  Support Radiolab by becoming a member today at