Nav: Home

New insights into genetics of fly longevity

March 25, 2019

Monday, March 25 2019, - Alexey Moskalev, Ph.D., Head of the Laboratory of Molecular Radiobiology and Gerontology Institute of Biology, and co-authors from the Institute of biology of Komi Science Center of RAS, Engelgard's Institute of molecular biology, involved in the study of the aging mechanisms and longevity of model animals announce the publication of a scientific article titled: "The Neuronal Overexpression of Gclc in Drosophila melanogaster Induces Life Extension With Longevity-Associated Transcriptomic Changes in the Thorax" in Frontiers in Genetics - a leading open science platform.

"The new study sheds light on longevity-associated transcriptome changes and will be useful for assessing the effects of genetic interventions that prevent premature aging," said Alexey Moskalev, PhD, head of the laboratory of Geroprotector and radioprotector technologies.

Aging inevitably leads to progressive organ dysfunction, creating a major problem for modern medicine that seems to have required many parallel tissue-specific interventions slowing down aging of the whole organism. Sarcopenia is primarily a disease of the elderly, characterized by the loss of skeletal muscle function and mass. A number of studies showed that muscle tissue undergoes sufficient alterations in gene expression patterns, during aging in mammals and flies.

"Alexey Moskalev is one of the rising young stars in biogerontology and this study further advances our understanding of aging in flies. Aging is not only a fly problem but a process that concerns everyone on the planet regardless of race, sex or nationality. It is a global challenge that should be addressed through massive international collaborations and Dr. Moskalev is helping build a community of scientists working in longevity biotechnology", said Alex Zhavoronkov, PhD, CEO of Insilico Medicine and adjunct professor at the Buck Institute for Research on Aging.

One of the major factors contributing to the decline of muscular function may be the decrease in antioxidant protection by glutathione. To prove this hypothesis, Alexey Moskalev, jointly with other scientists, investigated the effect of neuronal overexpression of the pro-longevity gene Gclc on age-related transcriptome changes in the thorax of Drosophila melanogaster. Previously, the authors showed that overexpression of this gene, encoding a cysteine ligase catalytic subunit, led to lifespan increase and decline of the spontaneous locomotor activity of flies. This study demonstrated 58 differentially expressed genes induced by Gclc overexpression involved in a variety of pathways of metabolism, such as Drug metabolism, Metabolism of xenobiotics by cytochrome P450, Carbohydrate metabolism. Also, changes in expression of genes related to the immune system, circadian rhythmicity, and downregulation of genes involved in proteolysis have been shown.
For further information, images or interviews, please contact:

Alexey Moskalev

About the Institute of biology of Komi Science Center of RAS

The Institute of Biology of Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences (IB Komi SC UB RAS) was founded in 1962. The Institute is the largest academic research centre of the East European part of Russia, with biology and ecology as two primary areas of research. The Institute consists of six departments and four laboratories, the Zoological museum, the Botanical garden and the Herbarium (SYKO). The main fields of research include the study of biodiversity, structural and functional organization, stability and productivity of taiga and tundra ecosystems, biological effects of ionizing radiation and other physico-chemical factors on cells, living organisms and natural ecosystems; problems of radiation and ecological genetics, as well as the development of methods for monitoring, bioindication; creation of inventories and databases of biological resources of the European North-East with the use of remote sensing and GIS technologies.

The official website:

Please follow the link below to read the article:

InSilico Medicine, Inc.

Related Aging Articles:

Researchers discover new cause of cell aging
New research from the USC Viterbi School of Engineering could be key to our understanding of how the aging process works.
Deep Aging Clocks: The emergence of AI-based biomarkers of aging and longevity
The advent of deep biomarkers of aging, longevity and mortality presents a range of non-obvious applications.
Intelligence can link to health and aging
For over 100 years, scientists have sought to understand what links a person's general intelligence, health and aging.
Putting the brakes on aging
Salk Institute researchers have developed a new gene therapy to help decelerate the aging process.
New insights into the aging brain
A group of scientists at the Gladstone Institutes investigated why the choroid plexus contains so much more klotho than other brain regions.
We all want 'healthy aging,' but what is it, really? New report looks for answers
Led by Paul Mulhausen, MD, MHS, FACP, AGSF, colleagues from the American Geriatrics Society (AGS) set looking critically at what 'healthy aging' really means.
New insight into aging
Researchers at the Montreal Neurological Institute and Hospital (The Neuro) of McGill University examined the effects of aging on neuroplasticity in the primary auditory cortex, the part of the brain that processes auditory information.
Aging may be as old as life itself
Aging has had a bad rap since it has long been considered a consequence of biology's concentrated effort on enhancing survival through reproductivity.
A new link between cancer and aging
Human lung cancer cells resist dying by controlling parts of the aging process, according to findings published online May 10th in the Journal of Biological Chemistry.
American Federation for Aging Research experts featured in PBS special: Incredible Aging
Fourteen AFAR experts are among those featured in
More Aging News and Aging Current Events

Top Science Podcasts

We have hand picked the top science podcasts of 2019.
Now Playing: TED Radio Hour

Why do we revere risk-takers, even when their actions terrify us? Why are some better at taking risks than others? This hour, TED speakers explore the alluring, dangerous, and calculated sides of risk. Guests include professional rock climber Alex Honnold, economist Mariana Mazzucato, psychology researcher Kashfia Rahman, structural engineer and bridge designer Ian Firth, and risk intelligence expert Dylan Evans.
Now Playing: Science for the People

#541 Wayfinding
These days when we want to know where we are or how to get where we want to go, most of us will pull out a smart phone with a built-in GPS and map app. Some of us old timers might still use an old school paper map from time to time. But we didn't always used to lean so heavily on maps and technology, and in some remote places of the world some people still navigate and wayfind their way without the aid of these tools... and in some cases do better without them. This week, host Rachelle Saunders...
Now Playing: Radiolab

Dolly Parton's America: Neon Moss
Today on Radiolab, we're bringing you the fourth episode of Jad's special series, Dolly Parton's America. In this episode, Jad goes back up the mountain to visit Dolly's actual Tennessee mountain home, where she tells stories about her first trips out of the holler. Back on the mountaintop, standing under the rain by the Little Pigeon River, the trip triggers memories of Jad's first visit to his father's childhood home, and opens the gateway to dizzying stories of music and migration. Support Radiolab today at