Emory researchers report new strategy to reduce emotional and physical distress associated with cancer treatment

March 28, 2001

A study conducted at Emory University was successful in preventing depression, anxiety and physical distress in cancer patients with the prophylactic use of antidepressants, the March 29 issue of New England Journal of Medicine reports.

Andrew Miller, M.D., professor, Department of Psychiatry and Behavioral Sciences at Emory University School of Medicine, and Emory colleagues in the Department of Psychiatry and Behavioral Sciences, Winship Cancer Institute and Rollins School of Public Health, found in a study of 40 patients with malignant melanoma that providing the antidepressant paroxetine (Paxil) two weeks before beginning cancer treatment significantly reduced the development of clinical depression. Also reduced was the number of patients who had to discontinue cancer treatment because of severe emotional or physical distress.

The study's objective was to prevent depression by treating patients who were about to be given Interferon (IFN)-alpha, an agent predominantly used to treat malignant disorders and infectious diseases. Although an effective therapy, IFN-alpha has been associated with high rates of central nervous system side effects, including the development of severe depression that in some instances has led to suicide. Patients were randomly assigned either a placebo or the paroxetine. Almost 50% of patients who got the placebo became significantly depressed while receiving the cancer treatment versus only about 10% in the group that received the antidepressant.

"Patients who received the antidepressant also experienced significantly less anxiety, less concentration and memory problems and far less intense physical symptoms such as abdominal discomfort, pain and fatigue, " said Dr. Miller. "We wonder whether such an approach may have broader applications, including prevention of physical and emotional complications of other cancer treatments and possibly even major surgery."

Pretreatment with paroxetine appears to represent an effective strategy for minimizing IFN-alpha-induced depression and neurotoxicity. In addition, these data provide the first demonstration of the prophylactic use of antidepressants in medically ill patients at high risk for neuropsychiatric disorders.
Other Emory investigators include Charles B. Nemeroff, M.D., Ph.D, Dominique L. Musselman, M.D., Jane F. Gumnick, M.D., Suzanne Penna, B.A., Rebecca Goodkin, B.A., Department of Psychiatry and Behavioral Sciences; David H. Lawson, M.D., Winship Cancer Institute; Amita Manatunga, Ph.D., Department of Biostatistics, Rollins School of Public Health.

National Institute of Mental Health (NIMH), Schering-Plough Pharmaceuticals and GlaxoSmithKline funded this study.

Emory University Health Sciences Center

Related Antidepressants Articles from Brightsurf:

Measuring brainwaves while sleeping can tell if you should switch antidepressants
Scientists have discovered that measuring brainwaves produced during REM sleep can predict whether a patient will respond to treatment from depression.

Antibodies: the body's own antidepressants
Antibodies can be a blessing or a curse to the brain -- it all depends on their concentration.

Are some antidepressants less risky for pregnant women?
About one in ten women in Qu├ębec will suffer from depression during pregnancy.

The effect of taking antidepressants during pregnancy
Exposure to antidepressants during pregnancy and the first weeks of life can alter sensory processing well into adulthood, according to research in mice recently published in eNeuro.

Significantly fewer pregnant women take antidepressants
A pregnancy is not always a happy event and as many as 10-15% of pregnant women in Denmark have depressive symptoms.

Antidepressants reduce deaths by more than a third in patients with diabetes
Antidepressants reduce deaths by more than a third in patients with diabetes and depression, according to a study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

Antidepressants can reduce the empathic empathy
Depression is a disorder that often comes along with strong impairments of social functioning.

Possible link between autism and antidepressants use during pregnancy
An international team led by Duke-NUS Medical School has found a potential link between autistic-like behaviour in adult mice and exposure to a common antidepressant in the womb.

When neurons are out of shape, antidepressants may not work
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed medication for major depressive disorder (MDD), yet scientists still do not understand why the treatment does not work in nearly thirty percent of patients with MDD.

Next-generation metabolomics may facilitate the discovery of new antidepressants
Antidepressants have become one of the most commonly prescribed drugs.

Read More: Antidepressants News and Antidepressants Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.