Death rates from cesarean section far higher in developing countries

March 28, 2019

Caesarean sections are disproportionately threatening the lives of women and babies in low and middle-income countries (LMIC), according to a study led by Queen Mary University of London.

The analysis of data from 12 million pregnancies, published in The Lancet, finds that maternal deaths in LMICs are 100 times higher than in some high-income countries, and a third of all babies in some regions do not survive caesarean section.

First author Dr Soha Sobhy from Queen Mary University of London said: "To our knowledge, this is the largest and most comprehensive study to-date on the risks of death following caesarean section. The outcomes for women in low and middle-income countries are far worse than we expected.

"In sub-Saharan Africa, one in 100 women who has a caesarean section will die - 100 times more than women in the UK. The outcomes for their babies are even worse, with eight per cent not surviving longer than a week."

Lead author Professor Shakila Thangaratinam from Queen Mary University of London added: "Caesarean sections are the most commonly performed operation worldwide. They are meant to be life saving for both mother and baby, but because of many factors, such as poor access, late referrals, inappropriate procedures, poor resources and training, this is not always the case.

"Now that we know the risk factors and countries associated with poor outcomes, we can make a more targeted effort to improve conditions for mothers globally, so that timely and safe caesarean sections can be done wherever they are needed."

Every year 300,000 women die during childbirth, 99 per cent of which are from LMICs. Timely access to caesarean section when needed is required for safe childbirth, but procedures are being performed 'too little, too late', or 'too many, too soon'.

The analysis looked at data from 196 studies from 67 LMICs, covering 12 million pregnancies, and found that:Based on these findings, the researchers are calling on policy makers and healthcare professionals to improve access to surgery, promote appropriate use of the procedure, provide safe surgical environments, and increase neonatal resuscitation to help improve outcomes to babies.

The team also highlight that training in labour management needs to cover why caesarean sections are carried out, in order to reduce inappropriate caesarean sections, and promote a reduction in caesarean sections performed in the second stage of labour, which are the most risky.

The finding that postpartum haemorrhage was the commonest cause of maternal death following caesarean section, highlights gaps in resource and skills to manage massive obstetric haemorrhage, and a need for specific training in this area.

The work was carried out at Barts Research Centre for Women's Health, based at Queen Mary University of London, funded by Barts Charity, and in collaboration with the World Health Organization.

Francesca Gliubich, Director of Grants at Barts Charity said: "The Barts Research Centre for Women's Health is undertaking many important studies and Barts Charity are proud to fund their work. This latest research will help to inform global health policies around Caesarean sections and help to avoid the preventable deaths of both mothers and babies."

The study was also funded by the National Institute for Health Research (NIHR), Ammalife Charity and the ELLY Appeal. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care.

The findings are limited by the differences in the characteristics of population and the team could not adjust for underlying obstetric and socio economic factors. It was also not possible to determine if the adverse outcomes following caesarean section were due to the procedure or from a pre-existing risk factor. Very few studies were published in some regions such as Europe and central Asia and Middle East and North Africa, and may affect the generalisability of the findings.
-end-
For more information, please contact:

Joel Winston
Public Relations Manager (School of Medicine and Dentistry)
Queen Mary University of London
j.winston@qmul.ac.uk
Tel: +44 (0)20 7882 7943 / +44 (0)7968 267 064

Notes to the editor

Available here after the embargo lifts: http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)32386-9/fulltext

About Queen Mary University of London

At Queen Mary University of London, we believe that a diversity of ideas helps us achieve the previously unthinkable.

In 1785, Sir William Blizard established England's first medical school, The London Hospital Medical College, to improve the health of east London's inhabitants. Together with St Bartholomew's Medical College, founded by John Abernethy in 1843 to help those living in the City of London, these two historic institutions are the bedrock of Barts and The London School of Medicine and Dentistry.

Today, Barts and The London continues to uphold this commitment to pioneering medical education and research. Being firmly embedded within our east London community, and with an approach that is driven by the specific health needs of our diverse population, is what makes Barts and The London truly distinctive.

Our local community offer to us a window to the world, ensuring that our ground-breaking research in cancer, cardiovascular and inflammatory diseases, and population health not only dramatically improves the outcomes for patients in London, but also has a far-reaching global impact.

This is just one of the many ways in which Queen Mary is continuing to push the boundaries of teaching, research and clinical practice, and helping us to achieve the previously unthinkable.

About the National Institute for Health Research

The National Institute for Health Research (NIHR) is the nation's largest funder of health and care research. The NIHR: The NIHR was established in 2006 to improve the health and wealth of the nation through research, and is funded by the Department of Health and Social Care. In addition to its national role, the NIHR commissions applied health research to benefit the poorest people in low- and middle-income countries, using Official Development Assistance funding.

Queen Mary University of London

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