Limiting tumors' ability to hide from the immune system

March 29, 2018

Scientists have discovered a way to stop tumors from shedding certain proteins that the immune system uses to identify and attack tumors. The new method reduces the spread of melanoma and lung cancer in mice, a new study shows. Many human cancers exhibit the stress proteins MICA and MICB, which the immune system, particularly natural killer cells, use to identify cells that should be eliminated. In an act of defiance, cancer cells produce enzymes that cleave these anchored proteins, essentially shedding the proteins and evading detection. Lucas Ferrari de Andrade et al. suspected that it would be possible to stop tumors from shedding these proteins using antibodies that target the site where MICA and MICB proteins are cleaved. They studied the effect of such an antibody, mAb 7C6, in mouse models of melanoma and lung cancer, finding that the antibody not only increased the presence of MICA and MICB on cancer cells, but also increased the infiltration of natural killer cells within tumors. In mice with metastatic melanoma that had spread to the lungs, treatment with mAb 7C6 helped reduce tumor load, the authors report. In a related Perspective, Adelheid Cerwenka and Lewis Lanier write, "The study introduces an exciting concept for a therapeutic monoclonal antibody with the potential to improve natural killer cell-based cancer immunotherapy."

American Association for the Advancement of Science

Related Lung Cancer Articles from Brightsurf:

State-level lung cancer screening rates not aligned with lung cancer burden in the US
A new study reports that state-level lung cancer screening rates were not aligned with lung cancer burden.

The lung microbiome may affect lung cancer pathogenesis and prognosis
Enrichment of the lungs with oral commensal microbes was associated with advanced stage disease, worse prognosis, and tumor progression in patients with lung cancer, according to results from a study published in Cancer Discovery, a journal of the American Association for Cancer Research.

New analysis finds lung cancer screening reduces rates of lung cancer-specific death
Low-dose CT screening methods may prevent one death per 250 at-risk adults screened, according to a meta-analysis of eight randomized controlled clinical trials of lung cancer screening.

'Social smokers' face disproportionate risk of death from lung disease and lung cancer
'Social smokers' are more than twice as likely to die of lung disease and more than eight times as likely to die of lung cancer than non-smokers, according to research presented at the European Respiratory Society International Congress.

Lung cancer therapy may improve outcomes of metastatic brain cancer
A medication commonly used to treat non-small cell lung cancer that has spread, or metastasized, may have benefits for patients with metastatic brain cancers, suggests a new review and analysis led by researchers at St.

Cancer mortality continues steady decline, driven by progress against lung cancer
The cancer death rate declined by 29% from 1991 to 2017, including a 2.2% drop from 2016 to 2017, the largest single-year drop in cancer mortality ever reported.

Cancer-sniffing dogs 97% accurate in identifying lung cancer, according to study in JAOA
The next step will be to further fractionate the samples based on chemical and physical properties, presenting them back to the dogs until the specific biomarkers for each cancer are identified.

Lung transplant patients face elevated lung cancer risk
In an American Journal of Transplantation study, lung cancer risk was increased after lung transplantation, especially in the native (non-transplanted) lung of single lung transplant recipients.

Proposed cancer treatment may boost lung cancer stem cells, study warns
Epigenetic therapies -- targeting enzymes that alter what genes are turned on or off in a cell -- are of growing interest in the cancer field as a way of making a cancer less aggressive or less malignant.

Are you at risk for lung cancer?
This question isn't only for people who've smoked a lot.

Read More: Lung Cancer News and Lung Cancer Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to