Nav: Home

Poor lung function in shorter people linked to increased risk of heart disease

March 29, 2019

Results from a study led by researchers from Queen Mary University of London has found that an association between shorter stature and higher risk of heart disease is mainly attributed to our lungs.

In the study, published in the journal Communications Biology, researchers examined over 800 places in the human genome known to be associated with adult height and also evaluated data suggesting that lower height increases the risk of developing type 2 diabetes and coronary heart disease.

The authors found no evidence of a causal link between height and type 2 diabetes risk once an individual's body mass index was taken into account but reported a causal relationship between height and heart disease risk.

Many traditional risk factors for heart disease were investigated including, cholesterol, triglycerides, blood pressure, fat percentage, and socio-economic parameters including education and income, but results showed that they only account for a very small part of the effect of height on heart disease risk. The way our lungs function accounted for most of this effect.

Lead author, Dr Eirini Marouli from Queen Mary University of London said: "Understanding the causal relationship behind an observation such as the inverse relationship between adult height and heart disease risk is important in advancing our knowledge about the disease and has the potential to point towards lifestyle interventions that can impact disease prevention.

"Our results suggest that we need to assess lung function alongside someone's height to have a better handle in predicting their risk in developing heart disease."

Heart attacks are one of the most common causes of death worldwide. Nearly one in six men and one in ten women die from heart disease, therefore identifying heart disease risk factors, especially those that could be modified through early lifestyle interventions, is specifically important.

According to Professor Panos Deloukas from Queen Mary University of London, senior author of the study: "Individuals of shorter statute can consider regular exercise and the avoidance of a sedentary lifestyle and smoking to reduce their risk of heart disease given that, as we showed in this study, the effect of shorter height on the risk of heart disease is mediated by lung function.

"Our findings and further studies of this nature, empower efforts to promote a healthy lifestyle and in particular physical activity that can lead to improved lung function."
-end-
For more information, please contact:

Joel Winston
Public Relations Manager (School of Medicine and Dentistry)
Queen Mary University of London
j.winston@qmul.ac.uk
Tel: +44 (0)20 7882 7943 / +44 (0)7968 267 064

Notes to the editor

Research paper: Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease, by Eirini Marouli et al. Communications Biology

Queen Mary University of London

Related Diabetes Articles:

Maternal gestational diabetes linked to diabetes in children
Children and youth of mothers who had gestational diabetes during pregnancy are at increased risk of diabetes themselves, according to new research published in CMAJ (Canadian Medical Association Journal).
Two diabetes medications don't slow progression of type 2 diabetes in youth
In youth with impaired glucose tolerance or recent-onset type 2 diabetes, neither initial treatment with long-acting insulin followed by the drug metformin, nor metformin alone preserved the body's ability to make insulin, according to results published online June 25 in Diabetes Care.
People with diabetes visit the dentist less frequently despite link between diabetes, oral health
Adults with diabetes are less likely to visit the dentist than people with prediabetes or without diabetes, finds a new study led by researchers at NYU Rory Meyers College of Nursing and East Carolina University's Brody School of Medicine.
Diabetes, but not diabetes drug, linked to poor pregnancy outcomes
New research indicates that pregnant women with pre-gestational diabetes who take metformin are at a higher risk for adverse pregnancy outcomes -- such as major birth defects and pregnancy loss -- than the general population, but their increased risk is not due to metformin but diabetes.
New oral diabetes drug shows promise in phase 3 trial for patients with type 1 diabetes
A University of Colorado Anschutz Medical Campus study finds sotagliflozin helps control glucose and reduces the need for insulin in patients with type 1 diabetes.
Can continuous glucose monitoring improve diabetes control in patients with type 1 diabetes who inject insulin
Two studies in the Jan. 24/31 issue of JAMA find that use of a sensor implanted under the skin that continuously monitors glucose levels resulted in improved levels in patients with type 1 diabetes who inject insulin multiple times a day, compared to conventional treatment.
Complications of type 2 diabetes affect quality of life, care can lead to diabetes burnout
T2D Lifestyle, a national survey by Health Union of more than 400 individuals experiencing type 2 diabetes (T2D), reveals that patients not only struggle with commonly understood complications, but also numerous lesser known ones that people do not associate with diabetes.
A better way to predict diabetes
An international team of researchers has discovered a simple, accurate new way to predict which women with gestational diabetes will develop type 2 diabetes after delivery.
The Lancet Diabetes & Endocrinology: Older Americans with diabetes living longer without disability, US study shows
Older Americans with diabetes born in the 1940s are living longer and with less disability performing day to day tasks than those born 10 years earlier, according to new research published in The Lancet Diabetes & Endocrinology journal.
Reverse your diabetes -- and you can stay diabetes-free long-term
A new study from Newcastle University, UK, has shown that people who reverse their diabetes and then keep their weight down remain free of diabetes.
More Diabetes News and Diabetes Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Rethinking Anger
Anger is universal and complex: it can be quiet, festering, justified, vengeful, and destructive. This hour, TED speakers explore the many sides of anger, why we need it, and who's allowed to feel it. Guests include psychologists Ryan Martin and Russell Kolts, writer Soraya Chemaly, former talk radio host Lisa Fritsch, and business professor Dan Moshavi.
Now Playing: Science for the People

#538 Nobels and Astrophysics
This week we start with this year's physics Nobel Prize awarded to Jim Peebles, Michel Mayor, and Didier Queloz and finish with a discussion of the Nobel Prizes as a way to award and highlight important science. Are they still relevant? When science breakthroughs are built on the backs of hundreds -- and sometimes thousands -- of people's hard work, how do you pick just three to highlight? Join host Rachelle Saunders and astrophysicist, author, and science communicator Ethan Siegel for their chat about astrophysics and Nobel Prizes.