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Over 50 percent of obese Spanish workers are metabolically healthy

March 31, 2016

About half of obese individuals in a working population in Spain are metabolically healthy - they are obese but do not present metabolic abnormalities like disturbed insulin signaling or inflammation, according to a study published in the open access journal BMC Public Health.

Researchers at Hospital del Mar (Universitat Autonoma de Barcelona & CIBER Obn), Cualtis and Eli Lilly Spain gathered data on 451,432 Spanish workers to examine, for the first time, the prevalence of metabolically healthy obese individuals in the working population, as well as the differences between them and metabolically unhealthy obese and non-obese individuals.

The researchers found that overweight and obese individuals who were metabolically healthy tended to be younger and were more likely to be women. They were more likely to participate in physical exercise than their metabolically unhealthy counterparts, and were less likely to smoke or to be heavy drinkers.

Factors found to be most strongly associated with being metabolically unhealthy were BMI and age, high cholesterol, being male, a smoker or a heavy drinker, and lack of physical exercise.

Individuals that were normal or underweight but metabolically unhealthy were more likely to have sedentary lifestyles than metabolically healthy individuals. They were also more likely to be older, male, blue collar workers, smokers and heavy drinkers.

The Ibermutuamur CArdisvascular RIsk Assessment (ICARIA) study was conducted among workers enrolled in a health insurance scheme that covers 8% of the Spanish working population and includes workers from all activity sectors and geographical areas of Spain. As part of the ICARIA study, the researchers gathered information on age, sex, occupation, tobacco and alcohol consumption, physical exercise and medical history from 451,432 individuals, 70,053 (15.5%) of whom were obese. Participants also underwent a physical examination that included weight, height, waist circumference and blood pressure recordings.

According to BMI, the researchers categorized participants as underweight, normal weight, overweight or obese. They also categorized them as being either manual (blue collar) or non-manual (white collar) workers, as well as according to their smoking status (former or current), alcohol consumption, and level of exercise. Metabolic health was evaluated according to five criteria for metabolic syndrome: waist circumference, triglyceride and cholesterol levels, blood pressure, and fasting blood sugar. Participants were considered metabolically healthy, if they met two or less out of the five criteria.

Out of the overweight group, 87.1% were found to be metabolically healthy, while 55.1% were found to be metabolically healthy in the obese group. Out of underweight individuals, 99.5% were metabolically healthy, while 97.8% of normal weight individuals were metabolically healthy.

Even though the prevalence of metabolic health was found to be relatively high even in obese individuals in this study, the authors note that results are influenced by which definition of metabolic health is used. For example, the researchers also tested more stringent criteria to assess metabolic health, considering only individuals who met none of the criteria for metabolic syndrome to be metabolically healthy. Under these more stringent criteria, the most obese study subjects previously found to be metabolically healthy were found to be metabolically unhealthy.

As this was a cross-sectional study, no causal relationships could be established. However, obese individuals who are metabolically healthy have distinct characteristics - such as less disturbed insulin signaling or inflammation - that may make them more responsive to dietary interventions targeted at modifiable risk factors like relative weight, smoking or heavy drinking.

While metabolically healthy obese individuals could be at a lower risk than metabolically unhealthy individuals of developing associated conditions like type 2 diabetes, hypertension and coronary heart disease, previous studies have found that metabolically healthy obese individuals show subclinical (pre-symptomatic) signs of cardiovascular disease, and that they may be at an increased long-term risk of diabetes and cardiovascular events. Targeted interventions may prevent metabolically health obese and overweight individuals from becoming unhealthy, according to the researchers. They may be particularly effective in the working population, as the prevalence of metabolically healthy obese people in this population was found to be high.

Albert Goday, lead author of the study, said: "The implementation of health promotion programs in this population could reduce the likelihood of transition to a metabolically unhealthy phenotype and/or the risk of developing hypertension, diabetes and cardiovascular disease."
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Anne Korn
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BioMed Central
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Notes to editor:

1. Prevalence and clinical characteristics of metabolically healthy obese individuals and other obese/non-obese metabolic phenotypes in a working population: results from the Icaria study
Albert Goday, Eva Calvo, Luis Alberto Vázquez, Elena Caveda, Teresa Margallo, Carlos Catalina-Romero and Jesús Reviriego
BMC Public Health 2016
DOI: 10.1186/s12889-016-2921-4

For an embargoed copy of the research article, please contact Anne Korn at BioMed Central.

After the embargo lifts, the article will be available at the journal website here: http://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-016-2921-4

Please name the journal in any story you write. If you are writing for the web, please link to the article. All articles are available free of charge, according to BioMed Central's open access policy.

2. BMC Public Health is an open access, peer-reviewed journal that considers articles on the epidemiology of disease and the understanding of all aspects of public health. The journal has a special focus on the social determinants of health, the environmental, behavioral, and occupational correlates of health and disease, and the impact of health policies, practices and interventions on the community.

3. BioMed Central is an STM (Science, Technology and Medicine) publisher which has pioneered the open access publishing model. All peer-reviewed research articles published by BioMed Central are made immediately and freely accessible online, and are licensed to allow redistribution and reuse. BioMed Central is part of Springer Nature, a major new force in scientific, scholarly, professional and educational publishing, created in May 2015 through the combination of Nature Publishing Group, Palgrave Macmillan, Macmillan Education and Springer Science+Business Media. http://www.biomedcentral.com

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