News tips from the Journal of Neuroscience

April 03, 2007

1. Tracking Down Anomalous L Channels
Alexandra Koschak, Gerald J. Obermair, Francesca Pivotto, Martina J. Sinnegger-Brauns, Jörg Striessnig, and Daniela Pietrobon

In this week's Journal, Koschak et al. identify Cav1.2 as the pore-forming subunit of anomalous L-type calcium channels in neurons, a subclass of L-type channels that show long reopenings at negative voltages after a strong depolarization. These channels coexist with conventional L-type channels in rat cerebellar granule cells as well as other neurons. The authors found by quantitative reverse transcription-PCR that the bulk of L-type calcium channel transcripts in granule cells encoded Cav1.2 subunits, whereas the remainder encoded Cav1.3. Single-channel recording from granule cells in Cav1.3-/- mice revealed normal amounts of both gating types. In Cav1.2DHP-/- mice, which express mutant Cav1.2 channels that are insensitive to dihydropyridines (DHPs), the long reopenings in neurons treated with DHP were similar to anomalous currents in wild-type neurons and shorter than typical DHP-induced long openings. The authors suggest that the anomalous openings may drive L-type channel-dependent gene transcription in long-lasting plasticity.

2. An Interhemispheric Effect on Whisker Plasticity
Stanislaw Glazewski, Brett L. Benedetti, and Alison L. Barth

Glazewski et al. did some fancy whisker trimming in mice to examine experience-dependent plasticity in barrel cortex. In rodents, whisker deflection excites neurons in the contralateral somatosensory cortex, whereas concurrent stimulation of ipsilateral whiskers is inhibitory. The authors recorded responses in single neurons in barrel cortex after deflection of contralateral whiskers. Mice deprived of ipsilateral whiskers for 1 week had increased cortical receptive fields to contralateral whisker stimulation. Next, the mice got an "all-but-one" trim in which all whiskers but one were removed on the contralateral side, with or without removal of ipsilateral whiskers. When ipsilateral whiskers were shaved, the spared whisker responses increased for neurons within the barrel and in surrounding neurons. As expected, spared whisker receptive fields expanded into neighboring neurons deprived of whiskers. However, when ipsilateral whiskers were intact, spared whisker responses were relatively reduced, suggesting that interhemispheric sensory input dampens receptive field plasticity.

3. Stop-and-Go Tract Tracing
Adam R. Aron, Tim E. Behrens, Steve Smith, Michael J. Frank, and Russell A. Poldrack

Aron et al. this week mapped a connection between brain regions that control cognitive "stop" signals. The authors looked for a direct link between inferior frontal cortex (IFC) and subthalamic nucleus (STN) in human subjects using diffusion-weighted imaging tractography, a form of magnetic resonance imaging (MRI). They identified a white matter tract between STN and IFC in the right hemisphere; each of these regions also projected to the presupplementary motor area (preSMA). Next, subjects were instructed to stop a motor task command under some conditions and to ignore a stop signal under others. Functional MRI revealed increased activity in the IFC, STN, and preSMA when a stop signal was delivered under the noncritical condition, similar to outright stop responses. In this network, preSMA may serve a conflict-monitoring function for the stop signals involving IFC and STN.

4. An Old Treatment for Epilepsy and a New Cellular Mechanism
Weiyuan Ma, Jim Berg, and Gary Yellen

A low-carb ketogenic diet, although definitely not delicious, can be therapeutic in intractable epilepsy. However, seizure protection ends abruptly with sugar intake. Ma et al. looked for a cellular mechanism in GABAergic neurons of the substantia nigra pars reticulata. These neurons normally fire at high rates, have been implicated in seizure spread, and express a metabolic sensor, the ATP-sensitive potassium channel KATP. In rodent brain slices, ketone bodies (β- hydroxybutyrate or acetoacetate) slowed the firing of these cells by ~10%. Pharmacological activation of normally silent KATP channels also slowed or silenced neuronal firing. The ketone-induced slowing was absent in mice lacking the Kir6.2 subunit of KATP channels in plasma membranes. In a twist yet to be fully resolved, the effect also required signaling through GABAB receptors. The authors propose that loss of glycolytic ATP production under ketogenic conditions lowers the ATP concentration at the plasma membrane and thus disinhibits KATP channels.

Society for Neuroscience

Related Neurons Articles from Brightsurf:

Paying attention to the neurons behind our alertness
The neurons of layer 6 - the deepest layer of the cortex - were examined by researchers from the Okinawa Institute of Science and Technology Graduate University to uncover how they react to sensory stimulation in different behavioral states.

Trying to listen to the signal from neurons
Toyohashi University of Technology has developed a coaxial cable-inspired needle-electrode.

A mechanical way to stimulate neurons
Magnetic nanodiscs can be activated by an external magnetic field, providing a research tool for studying neural responses.

Extraordinary regeneration of neurons in zebrafish
Biologists from the University of Bayreuth have discovered a uniquely rapid form of regeneration in injured neurons and their function in the central nervous system of zebrafish.

Dopamine neurons mull over your options
Researchers at the University of Tsukuba have found that dopamine neurons in the brain can represent the decision-making process when making economic choices.

Neurons thrive even when malnourished
When animal, insect or human embryos grow in a malnourished environment, their developing nervous systems get first pick of any available nutrients so that new neurons can be made.

The first 3D map of the heart's neurons
An interdisciplinary research team establishes a new technological pipeline to build a 3D map of the neurons in the heart, revealing foundational insight into their role in heart attacks and other cardiac conditions.

Mapping the neurons of the rat heart in 3D
A team of researchers has developed a virtual 3D heart, digitally showcasing the heart's unique network of neurons for the first time.

How to put neurons into cages
Football-shaped microscale cages have been created using special laser technologies.

A molecule that directs neurons
A research team coordinated by the University of Trento studied a mass of brain cells, the habenula, linked to disorders like autism, schizophrenia and depression.

Read More: Neurons News and Neurons Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to