Heart failure patients have improved outcomes following investigational stem cell treatment

April 04, 2016

LOS ANGELES (April 4, 2016) - An investigational stem cell therapy derived from patients' own blood marrow significantly improved outcomes in patients with severe heart failure, according to a study from the Cedars-Sinai Heart Institute.

The research was presented today as a late-breaking clinical trial at the American College of Cardiology Scientific Sessions in Chicago.

"This is an important step forward for heart patients in particular and for stem cell medicine in general," said Timothy D. Henry, MD, director of the Cardiology Division at the Cedars-Sinai Heart Institute and one of the study's lead authors. "The results indicate that stem cells could be ushering in a bright new era in heart failure treatments."

Results from the trial are published today online by peer-reviewed medical journal The Lancet. Henry is a lead author along with Amit N. Patel, MD, MS, of the University of Utah. Cedars-Sinai also was one of the lead enrollers in the study.

Called ixmyelocel-T, the stem cell treatment developed by pharmaceutical company Vericel is made from a patient's own bone marrow. A sample of marrow is extracted from the patient and sent to a laboratory, where it undergoes a two-week process to rapidly multiply the number of stem cells and enhance their quality. The stem cell-rich marrow is then infused into the patient's heart muscle during a minimally invasive, catheter-based procedure.

"Our intent is to increase the number of functioning cells in the heart muscle, which, in turn, strengthen the heart and result in alleviating or slowing the advance of severe heart failure," Henry said.

In the Phase II study, physicians followed 109 patients over a 12-month period. All were diagnosed with ischemic cardiomyopathy, a type of heart failure that usually results from a heart attack or coronary artery disease. The 58 patients who received the stem cell therapy showed a 37 percent lower rate of deaths, hospitalizations and worsening symptoms compared to 51 patients who received a placebo.

Results include:The Cedars-Sinai Heart Institute has a deep history of developing stem cell treatments for heart patients. In 2009, Eduardo Marbán, MD, PhD, director of the Heart Institute, led a team that completed the world's first procedure in which a patient's own heart tissue was used to grow specialized heart stem cells. The specialized cells were then injected back into the patient's heart in an effort to repair and regrow healthy muscle in a heart that had been injured by a heart attack. Results, published in The Lancet in 2012, showed that one year after receiving the investigational stem cell treatment, heart attack patients demonstrated a significant reduction in the size of the scar left on the heart muscle after a heart attack.

Since that first infusion, physicians in the Heart Institute have commenced multiple stem cell trials for a variety of heart patients. They also inaugurated a regenerative medicine clinic to evaluate heart and vascular disease patients for participation in stem cell medical studies throughout the U.S.

"Our focus is on finding each of our patients the most advanced treatment for their disease," Marbán said. "Stem cells offer us an opportunity to improve cardiac care, expand treatment options and transform the future of heart medicine."
About the Cedars-Sinai Heart Institute

The Cedars-Sinai Heart Institute is internationally recognized for outstanding heart care built on decades of innovation and leading-edge research. From cardiac imaging and advanced diagnostics to surgical repair of complex heart problems to the training of the heart specialists of tomorrow and research that is deepening medical knowledge and practice, the Cedars-Sinai Heart Institute is known around the world for excellence and innovations.

Cedars-Sinai Medical Center

Related Stem Cells Articles from Brightsurf:

SUTD researchers create heart cells from stem cells using 3D printing
SUTD researchers 3D printed a micro-scaled physical device to demonstrate a new level of control in the directed differentiation of stem cells, enhancing the production of cardiomyocytes.

More selective elimination of leukemia stem cells and blood stem cells
Hematopoietic stem cells from a healthy donor can help patients suffering from acute leukemia.

Computer simulations visualize how DNA is recognized to convert cells into stem cells
Researchers of the Hubrecht Institute (KNAW - The Netherlands) and the Max Planck Institute in Münster (Germany) have revealed how an essential protein helps to activate genomic DNA during the conversion of regular adult human cells into stem cells.

First events in stem cells becoming specialized cells needed for organ development
Cell biologists at the University of Toronto shed light on the very first step stem cells go through to turn into the specialized cells that make up organs.

Surprising research result: All immature cells can develop into stem cells
New sensational study conducted at the University of Copenhagen disproves traditional knowledge of stem cell development.

The development of brain stem cells into new nerve cells and why this can lead to cancer
Stem cells are true Jacks-of-all-trades of our bodies, as they can turn into the many different cell types of all organs.

Healthy blood stem cells have as many DNA mutations as leukemic cells
Researchers from the Princess Máxima Center for Pediatric Oncology have shown that the number of mutations in healthy and leukemic blood stem cells does not differ.

New method grows brain cells from stem cells quickly and efficiently
Researchers at Lund University in Sweden have developed a faster method to generate functional brain cells, called astrocytes, from embryonic stem cells.

NUS researchers confine mature cells to turn them into stem cells
Recent research led by Professor G.V. Shivashankar of the Mechanobiology Institute at the National University of Singapore and the FIRC Institute of Molecular Oncology in Italy, has revealed that mature cells can be reprogrammed into re-deployable stem cells without direct genetic modification -- by confining them to a defined geometric space for an extended period of time.

Researchers develop a new method for turning skin cells into pluripotent stem cells
Researchers at the University of Helsinki, Finland, and Karolinska Institutet, Sweden, have for the first time succeeded in converting human skin cells into pluripotent stem cells by activating the cell's own genes.

Read More: Stem Cells News and Stem Cells Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.