Nav: Home

Omega-3 fatty acid supplementation may treat autoimmunity in type 1 diabetes

April 04, 2017

Type I diabetes (T1D) is an autoimmune condition that develops after the immune system attacks and destroys pancreatic β cells, leading to impaired insulin production. Currently, no therapies can successfully reverse the damage or progression of autoimmune attacks in T1D, but recent findings have suggested that people with autoimmune conditions may benefit from supplementation with omega-3 fatty acid (FA), a type of polyunsaturated FA found in fish oil.

In this issue of the JCI, researchers in Allan Zhao's lab at Guangdong University of Technology determined that dietary supplementation with omega-3 FAs can diminish the inflammatory processes that contribute to development of T1D. In a mouse model of T1D, they observed that increasing omega-3 FA consumption improved glucose metabolism and reduced the occurrence of diabetes. These improvements were associated with reductions in pro-inflammatory signaling molecules as well as reductions in immune cell infiltration into pancreatic islets. Both dietary supplementation and gene therapy-mediated increases in omega-3 FAs led to long-term improvements in glucose and insulin levels. Moreover, the researchers observed signs of β-cell regeneration in the omega-3-treated T1D mice.

These findings suggest that increasing intake of omega-3 FAs could have beneficial effects by reducing the autoimmune responses that lead to T1D.
-end-
TITLE: ω-3 polyunsaturated fatty acids ameliorate type 1 diabetes and autoimmunity

AUTHOR CONTACT:

Allan Zhao
Guangdong University of Technology
zjzhao@scut.edu.cn

View this article at:http://www.jci.org/articles/view/87388?key=bbb2df2018c8c18d1e0b

JCI Journals

Related Diabetes Articles:

Maternal gestational diabetes linked to diabetes in children
Children and youth of mothers who had gestational diabetes during pregnancy are at increased risk of diabetes themselves, according to new research published in CMAJ (Canadian Medical Association Journal).
Two diabetes medications don't slow progression of type 2 diabetes in youth
In youth with impaired glucose tolerance or recent-onset type 2 diabetes, neither initial treatment with long-acting insulin followed by the drug metformin, nor metformin alone preserved the body's ability to make insulin, according to results published online June 25 in Diabetes Care.
People with diabetes visit the dentist less frequently despite link between diabetes, oral health
Adults with diabetes are less likely to visit the dentist than people with prediabetes or without diabetes, finds a new study led by researchers at NYU Rory Meyers College of Nursing and East Carolina University's Brody School of Medicine.
Diabetes, but not diabetes drug, linked to poor pregnancy outcomes
New research indicates that pregnant women with pre-gestational diabetes who take metformin are at a higher risk for adverse pregnancy outcomes -- such as major birth defects and pregnancy loss -- than the general population, but their increased risk is not due to metformin but diabetes.
New oral diabetes drug shows promise in phase 3 trial for patients with type 1 diabetes
A University of Colorado Anschutz Medical Campus study finds sotagliflozin helps control glucose and reduces the need for insulin in patients with type 1 diabetes.
More Diabetes News and Diabetes Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Rethinking Anger
Anger is universal and complex: it can be quiet, festering, justified, vengeful, and destructive. This hour, TED speakers explore the many sides of anger, why we need it, and who's allowed to feel it. Guests include psychologists Ryan Martin and Russell Kolts, writer Soraya Chemaly, former talk radio host Lisa Fritsch, and business professor Dan Moshavi.
Now Playing: Science for the People

#537 Science Journalism, Hold the Hype
Everyone's seen a piece of science getting over-exaggerated in the media. Most people would be quick to blame journalists and big media for getting in wrong. In many cases, you'd be right. But there's other sources of hype in science journalism. and one of them can be found in the humble, and little-known press release. We're talking with Chris Chambers about doing science about science journalism, and where the hype creeps in. Related links: The association between exaggeration in health related science news and academic press releases: retrospective observational study Claims of causality in health news: a randomised trial This...