Nav: Home

One monoclonal antibody protects against 2 lethal viruses

April 05, 2017

A new study reports that one human monoclonal antibody therapy protected nonhuman primates from the lethal hemorrhagic fevers caused by both Marburg and Ravn viruses. Since the first recognized outbreak of Marburg virus disease in 1967, the illness has proven fatal in roughly 80% of infected individuals, and no clinically approved approaches (including vaccines) currently exist. This gap in treatment options makes outbreaks even more difficult to detect and control, because infected individuals often don't report to clinics and unintentionally transmit the diseases to others. Similar to Ebola virus - a related member of the filovirus family - Marburg and Ravn viruses cause highly dangerous infections that can lead to fevers, vomiting, severe diarrhea, internal bleeding, and in many cases, death. What's more, the recent 2013 to 2016 Ebola epidemic further highlighted a troubling absence of preventative and therapeutic regimens to combat filoviruses. In search of a viable therapy, Chad Mire and colleagues showed that one of the antibodies (called MR191-N) that was previously isolated from the serum of a patient who survived Marburg virus disease prevented lethality in guinea pigs and nonhuman primates infected with Marburg and Ravn viruses. Importantly, nonhuman primates that received two doses of MR191-N at four and seven days after infection were able to clear the viruses, and 100% remained alive, whereas control animals all succumbed to their infections. The researchers say that before MR191 can be tested in a clinical setting, additional pharmacology and toxicology testing, as well as development under Good Manufacturing Practices, will be required.

American Association for the Advancement of Science

Related Viruses Articles:

Killing flu viruses with help from a frog
Frog mucus is loaded with molecules that kill bacteria and viruses, and researchers are beginning to investigate it as a potential source for new anti-microbial drugs.
Giant viruses may simply be a Frankenstein of mini viruses
The notion that giant viruses represent a potential fourth domain of life is now closer to being disproven, researchers say.
Discovered: Novel group of giant viruses
Viruses are thought to outnumber the microbes on Earth; both outnumber the stars in the Milky Way.
One monoclonal antibody protects against 2 lethal viruses
A new study reports that one human monoclonal antibody therapy protected nonhuman primates from the lethal hemorrhagic fevers caused by both Marburg and Ravn viruses.
Viruses in the oceanic basement
A team of scientists from the University of Hawai'i at Mānoa School of Ocean and Earth Science and Technology (SOEST) showed for the first time that many novel viruses are present in the fluids circulating deep in the rocky crust of the seafloor known as the ocean basement.
New link found between sex and viruses
Sexual reproduction and viral infections both rely on a functionally identical protein, according to new research.
Fighting viruses to improve agriculture
A University of California, Riverside researcher is leading a team that will receive $300,000 over two years to study the life cycles of viruses that are harmful to humans and agricultural plants.
Viruses in the genome important for our brain
Over millions of years retroviruses have been incorporated into our human DNA, where they today make up almost 10 per cent of the total genome.
World of viruses uncovered
A groundbreaking study of the virosphere of the most populous animals has uncovered 1,445 viruses, revealing people have only scratched the surface of the world of viruses -- but it is likely that only a few cause disease.
Your viruses could reveal your travel history, and more
The genomes of two distinct strains of the virus that causes the common lip cold sore, herpes simplex virus type 1, have been identified within an individual person -- an achievement that could be useful to forensic scientists for tracing a person's history.

Related Viruses Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Don't Fear Math
Why do many of us hate, even fear math? Why are we convinced we're bad at it? This hour, TED speakers explore the myths we tell ourselves and how changing our approach can unlock the beauty of math. Guests include budgeting specialist Phylecia Jones, mathematician and educator Dan Finkel, math teacher Eddie Woo, educator Masha Gershman, and radio personality and eternal math nerd Adam Spencer.
Now Playing: Science for the People

#517 Life in Plastic, Not Fantastic
Our modern lives run on plastic. It's in the computers and phones we use. It's in our clothing, it wraps our food. It surrounds us every day, and when we throw it out, it's devastating for the environment. This week we air a live show we recorded at the 2019 Advancement of Science meeting in Washington, D.C., where Bethany Brookshire sat down with three plastics researchers - Christina Simkanin, Chelsea Rochman, and Jennifer Provencher - and a live audience to discuss plastics in our oceans. Where they are, where they are going, and what they carry with them. Related links:...