Nav: Home

A viral explanation for celiac disease

April 06, 2017

An asymptomatic infection may play a role in facilitating celiac disease, a new study in mice reveals. The study highlights a previously unexplored connection between viral infection and oral tolerance to dietary antigens, showing how viruses can break this tolerance, which is otherwise needed to prevent undesirable responses to innocuous antigens ingested with food. Celiac disease, an autoimmune disorder where the ingestion of gluten leads to damage in the small intestine, has been thought to be primarily a genetic disease. Although epidemiological evidence has linked viral infections with the initiation of Celiac disease, experimental evidence of this connection is lacking. To gain more insights into this relationship, Romain Bouziat et al. studied the effects of two different reovirus strains that infect humans, type 1 Lang (T1L) and type 3 Dearing (T3D). The two viruses differ in pathogenesis, whereas T1L infects the intestine, perturbing regular immune functioning, T3D does not naturally infect the intestine. The researchers engineered a strain of T3D that is capable of infecting the intestines of mice and compared the effects of doing so to infection with T1L. They found that both viruses evoked protective immune responses, yet T1L evoked a more virulent response if the infection was caused in the presence of a dietary antibody, such as gluten or ovalbumin. Further exploration revealed that, upon exposure to T1L, antigen-presenting dendritic cells mounted a pathogenic T-cell response, one dependent on Interferon regulatory factor 1 (IRF1), which, coincidently, has been found at higher levels in the mucosa of children with celiac disease. The results are highlighted in a Perspective by Elena F. Verdu and Alberto Caminero.

American Association for the Advancement of Science

Related Celiac Disease Articles:

Infections in early life associated with increased risk for Celiac disease
Infections during infancy are associated with increased risk for gluten intolerance (celiac disease) later on.
ImmusanT publishes positive data from Phase 1 trials of Nexvax2 in celiac disease patients
ImmusanT announces the publication of positive data from Phase 1 clinical trials of the Nexvax2 therapeutic vaccine in celiac disease patients in The Lancet Gastroenterology and Hepatology.
Gluten-free diet not recommended for people without celiac disease
Long term dietary intake of gluten among people without celiac disease is not associated with risk of coronary heart disease -- and restricting gluten may result in a low intake of whole grains, which are associated with cardiovascular benefits, finds a study published by The BMJ today.
A viral explanation for celiac disease
An asymptomatic infection may play a role in facilitating celiac disease, a new study in mice reveals.
Seemingly innocuous virus can trigger celiac disease
Infection with reovirus, a common but otherwise harmless virus, can trigger the immune system response to gluten that leads to celiac disease, according to new research from the University of Chicago and the University of Pittsburgh School of Medicine.
More Celiac Disease News and Celiac Disease Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Teaching For Better Humans
More than test scores or good grades — what do kids need to prepare them for the future? This hour, guest host Manoush Zomorodi and TED speakers explore how to help children grow into better humans, in and out of the classroom. Guests include educators Olympia Della Flora and Liz Kleinrock, psychologist Thomas Curran, and writer Jacqueline Woodson.
Now Playing: Science for the People

#534 Bacteria are Coming for Your OJ
What makes breakfast, breakfast? Well, according to every movie and TV show we've ever seen, a big glass of orange juice is basically required. But our morning grapefruit might be in danger. Why? Citrus greening, a bacteria carried by a bug, has infected 90% of the citrus groves in Florida. It's coming for your OJ. We'll talk with University of Maryland plant virologist Anne Simon about ways to stop the citrus killer, and with science writer and journalist Maryn McKenna about why throwing antibiotics at the problem is probably not the solution. Related links: A Review of the Citrus Greening...