Study suggests suicide attempt survivors have lower sensitivity to bodily signals

April 07, 2020

People who have survived a suicide attempt are less sensitive to bodily signals related to their heart and breath, and have a higher tolerance for pain, suggest new findings published today in eLife.

Accurately predicting the risk of suicide in an individual is one of the greatest challenges encountered by clinicians. By identifying physical characteristics that differentiate people who have attempted suicide from those who have not, the study paves the way for future research aimed at identifying biological indicators of suicide risk.

Our brain constantly monitors the status of bodily signals that we need to stay alive, such as our heartbeat, our breath and pain caused by tissue damage to our skin. 'Interoception' describes the way the nervous system tracks the internal state of the body, helping us to perceive potential or actual threats and to act accordingly.

"Unlike most organisms, some humans are able to counteract these survival instincts through the act of suicide," explains lead author Danielle DeVille, a PhD student at the Laureate Institute for Brain Research, Tulsa, Oklahoma, US. "While experts have strived for decades to understand and prevent these deaths, we still don't know enough about the factors that contribute to suicidal behaviour."

To address this gap, DeVille and her colleagues conducted the first study that looks at whether blunted interoception is associated with a history of suicide attempts in people with psychiatric disorders, including depression, anxiety and post-traumatic stress disorder. Their study involved 34 participants with a history of suicide attempts in the last five years as compared to a matched psychiatric reference sample of 68 participants with no history of suicide attempts.

The team examined interoceptive processing in the participants using a panel of tasks. These include a breath-hold challenge, a cold-pressor test - where an individual immerses a hand in icy water and has their heart rate and skin conductance measured - and heartbeat perception. The researchers found that those who had attempted suicide tolerated the breath-hold and cold-pressor challenges for significantly longer than those who had not. Additionally, this group was less able to accurately perceive their heartbeat than non-attempters.

"We found that this 'interoceptive numbing' was linked to lower brain activity in the insular cortex, a region that closely tracks the internal state of the body," explains senior author Sahib Khalsa, Director of Clinical Operations at the Laureate Institute for Brain Research. "This numbing was not influenced by the presence a psychiatric disorder, by a history of having considered suicide, or by having taken psychiatric medications, and this suggests it was most closely linked to the act of attempting suicide."

Khalsa adds that these findings come with a number of limitations, including the fact that the study did not fully examine whether a history of considering suicide, versus making an actual attempt, has an independent impact on interoception. "It is also difficult to judge from our study whether the observed differences in interoception represent innate characteristics of the individuals involved, or whether they reflect an emerging response as they progressed from suicidal thinking to suicidal action," he says.

Despite these limitations, the authors say their work reveals a possible role of interoceptive dysfunction in distinguishing individuals at risk of suicide. It also lays the groundwork for further studies to determine whether measuring interoception in individuals can improve the ability to predict their suicide risk.
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Reference

The paper 'Diminished responses to bodily threat and blunted interoception in suicide attempters' can be freely accessed online at https://doi.org/10.7554/eLife.51593. Contents, including text, figures and data, are free to reuse under a CC BY 4.0 license.

Media contact

Emily Packer, Senior Press Officer
eLife
e.packer@elifesciences.org
01223 855373

About eLife

eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. We publish important research in all areas of the life and biomedical sciences, including Neuroscience, which is selected and evaluated by working scientists and made freely available online without delay. eLife also invests in innovation through open-source tool development to accelerate research communication and discovery. Our work is guided by the communities we serve. eLife is supported by the Howard Hughes Medical Institute, the Max Planck Society, the Wellcome Trust and the Knut and Alice Wallenberg Foundation. Learn more at https://elifesciences.org/about.

To read the latest Neuroscience research published in eLife, visit https://elifesciences.org/subjects/neuroscience.

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