People under 40 diagnosed with type 2 diabetes face excess risk of cardiovascular disease, death

April 08, 2019

DALLAS, April 8, 2019 -- People under age 40 who are diagnosed with Type 2 diabetes are more likely to have or die from cardiovascular disease than those of similar age without diabetes and the excess risks were more pronounced in younger women, according to new research in the American Heart Association's journal Circulation.

Researchers also found the excess risk for death, regardless of cause, for people diagnosed with Type 2 diabetes at age 80 or older significantly decreased and was the same as those of similar age without diabetes.

"Our study shows the differences in excess diabetes risk are tied to the how old the person is when they are diagnosed with Type 2 diabetes," said Naveed Sattar, M.D., Ph.D., lead author of the study and professor of Metabolic Medicine at the University of Glasgow in the United Kingdom.

Obesity rates have steadily increased in high-income countries and in young people over the last 30-40 years. As a result, more adolescents and young adults are being diagnosed with Type 2 diabetes more than ever before, according to the study.

This is the first study to compare the excess risks of dying from or developing cardiovascular disease in people diagnosed with Type 2 diabetes and to adjust the risk for such outcomes given how long a person has had diabetes -- an independent risk factor associated with cardiovascular disease risk.

Using data from the Swedish National Diabetes Registry, researchers followed 318,083 Type 2 diabetes patients and 1,575,108 age, sex and county-matched people as a control group from 1998 to 2013 for heart disease-related conditions. Death resulting from heart disease or any other cause was followed from 1998 to 2014.

Patients with Type 2 diabetes and similar aged controls had their risk for developing heart disease, heart attack, stroke, hospitalization from heart failure and atrial fibrillation assessed. Researchers also evaluated death from cardiovascular disease and any other conditions.

During a median follow-up of nearly two and half years, researchers compared results to control participants of similar age without Type 2 diabetes and found:"This suggests we need to be more aggressive in controlling risk factors in younger Type 2 diabetes populations and especially in women," Sattar said. "And, far less effort and resources could be spent screening people 80 and older for Type 2 diabetes unless symptoms are present. Furthermore, our work could also be used to encourage middle-aged people at elevated diabetes risk to adopt lifestyle changes to delay their diabetes by several years."

The study followed a majority white European population, so additional studies examining the role of cardiovascular disease in non-white populations who have Type 2 diabetes are needed.
-end-
Co-authors are Araz Rawshani, M.D.; Stefan Franzen, Ph.D.; Aidin Rawshani, M.D.; Ann-Marie Svensson, Ph.D.; Annika Rosengren, M.D.; Darren McGuire, M.D.; Bjorn Eliasson, M.D.; and Soffia Gudbjo?rnsdottir, M.D. Author disclosures are on the manuscript.

The Swedish Association of Local Authorities Regions, Swedish Heart and Lung Foundation, and Swedish Research Council funded the study.

Additional Resources:

Available multimedia is on right column of release link - https://newsroom.heart.org/news/people-under-40-diagnosed-with-type-2-diabetes-face-excess-risk-of-cardiovascular-disease-death?preview=225879f359c21ea4ca8bdf0e3c929f9f
After April 8, view the manuscript online.
Eating nuts may reduce cardiovascular disease risk for people with diabetes
Follow AHA/ASA news on Twitter @HeartNews

Statements and conclusions of study authors published in American Heart Association scientific journals are solely those of the study authors and do not necessarily reflect the association's policy or position. The association makes no representation or guarantee as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations and health insurance providers are available at https://www.heart.org/en/about-us/aha-financial-information.

About the American Heart Association

The American Heart Association is a leading force for a world of longer, healthier lives. With nearly a century of lifesaving work, the Dallas-based association is dedicated to ensuring equitable health for all. We are a trustworthy source empowering people to improve their heart health, brain health and well-being. We collaborate with numerous organizations and millions of volunteers to fund innovative research, advocate for stronger public health policies, and share lifesaving resources and information. Connect with us on heart.org, Facebook, Twitter or by calling 1-800-AHA-USA1.

American Heart Association

Related Diabetes Articles from Brightsurf:

Diabetes drug boosts survival in patients with type 2 diabetes and COVID-19 pneumonia
Sitagliptin, a drug to lower blood sugar in type 2 diabetes, also improves survival in diabetic patients hospitalized with COVID-19, suggests a multicenter observational study in Italy.

Making sense of diabetes
Throughout her 38-year nursing career, Laurel Despins has progressed from a bedside nurse to a clinical nurse specialist and has worked in medical, surgical and cardiac intensive care units.

Helping teens with type 1 diabetes improve diabetes control with MyDiaText
Adolescence is a difficult period of development, made more complex for those with Type 1 diabetes mellitus (T1DM).

Diabetes-in-a-dish model uncovers new insights into the cause of type 2 diabetes
Researchers have developed a novel 'disease-in-a-dish' model to study the basic molecular factors that lead to the development of type 2 diabetes, uncovering the potential existence of major signaling defects both inside and outside of the classical insulin signaling cascade, and providing new perspectives on the mechanisms behind insulin resistance in type 2 diabetes and possibly opportunities for the development of novel therapeutics for the disease.

Tele-diabetes to manage new-onset diabetes during COVID-19 pandemic
Two new case studies highlight the use of tele-diabetes to manage new-onset type 1 diabetes in an adult and an infant during the COVID-19 pandemic.

Genetic profile may predict type 2 diabetes risk among women with gestational diabetes
Women who go on to develop type 2 diabetes after having gestational, or pregnancy-related, diabetes are more likely to have particular genetic profiles, suggests an analysis by researchers at the National Institutes of Health and other institutions.

Maternal gestational diabetes linked to diabetes in children
Children and youth of mothers who had gestational diabetes during pregnancy are at increased risk of diabetes themselves, according to new research published in CMAJ (Canadian Medical Association Journal).

Two diabetes medications don't slow progression of type 2 diabetes in youth
In youth with impaired glucose tolerance or recent-onset type 2 diabetes, neither initial treatment with long-acting insulin followed by the drug metformin, nor metformin alone preserved the body's ability to make insulin, according to results published online June 25 in Diabetes Care.

People with diabetes visit the dentist less frequently despite link between diabetes, oral health
Adults with diabetes are less likely to visit the dentist than people with prediabetes or without diabetes, finds a new study led by researchers at NYU Rory Meyers College of Nursing and East Carolina University's Brody School of Medicine.

Diabetes, but not diabetes drug, linked to poor pregnancy outcomes
New research indicates that pregnant women with pre-gestational diabetes who take metformin are at a higher risk for adverse pregnancy outcomes -- such as major birth defects and pregnancy loss -- than the general population, but their increased risk is not due to metformin but diabetes.

Read More: Diabetes News and Diabetes Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.