Molecular Effect Of Vitamin E On Plaque Formation Identified

April 08, 1999

DALLAS - April 9, 1999 - Furthering evidence of the importance of vitamin E, researchers at UT Southwestern Medical Center at Dallas have identified the pathway that may allow the vitamin to block the trigger of arterial plaque formation at the molecular level.

As an antioxidant, vitamin E prevents the oxidation of low-density lipoproteins (LDL), the so-called "bad" cholesterol that contributes to heart disease. But research by Dr. Ishwarlal Jialal, professor of pathology and internal medicine, and Dr. Sridevi Devaraj, pathology instructor at UT Southwestern, also has found it to be a powerful player on the molecular level. Their latest work, published in the April 8th issue of Arteriosclerosis, Thrombosis and Vascular Biology, establishes for the first time that vitamin E inhibits the activity of an enyzme, 5-lipoxygenase, which is key to the initiation of plaque formation.

"Mounting evidence suggests that plaque formation is an inflammatory process," Devaraj said. This enzyme, 5-lipozygenase, produces a substance that stimulates the release of the protein interleukin-1beta (IL-1beta), which promotes plaque formation. Studies have shown it stimulates adhesion of white blood cells or monocytes to the arterial lining, promotes uptake of cholesterol by the cells and stimulates smooth-muscle-cell proliferation. Also, increased levels of IL-1beta have been observed in the coronary arteries of patients with heart disease and have been shown to correlate with the severity of the plaque.

"This is the first study showing that vitamin E has a novel biological anti-inflammatory effect on this crucial enzyme in cells that is more than just an antioxidant effect," Jialal said. "This pioneering work sheds more light on the possible prevention of heart disease with this antioxidant supplement, by decreasing not only oxidation of bad cholesterol but also by having important effects on cell function in the plaque."

In a 1996 study, these researchers showed that a supplement of 1,200 International Units (IUs) of vitamin E reduced the secretion of IL-1beta by about 80 percent in patients.

Jialal is also a senior researcher in the Center for Human Nutrition at UT Southwestern.

This work was supported in part by research grants from the American Diabetes Association and the General Clinical Research Center at UT Southwestern.
-end-
This news release is available on our World Wide Web home page at http://www.swmed.edu/home_pages/news/

To automatically receive news releases from UT Southwestern via e-mail, send a message to UTSWNEWS-REQUEST@listserv.swmed.edu. Leave the subject line blank and in the text box, type SUB UTSWNEWS



UT Southwestern Medical Center

Related Heart Disease Articles from Brightsurf:

Cellular pathway of genetic heart disease similar to neurodegenerative disease
Research on a genetic heart disease has uncovered a new and unexpected mechanism for heart failure.

Mechanism linking gum disease to heart disease, other inflammatory conditions discovered
The link between periodontal (gum) disease and other inflammatory conditions such as heart disease and diabetes has long been established, but the mechanism behind that association has, until now, remained a mystery.

New 'atlas' of human heart cells first step toward precision treatments for heart disease
Scientists have for the first time documented all of the different cell types and genes expressed in the healthy human heart, in research published in the journal Nature.

With a heavy heart: How men and women develop heart disease differently
A new study by researchers from McGill University has uncovered that minerals causing aortic heart valve blockage in men and women are different, a discovery that could change how heart disease is diagnosed and treated.

Heart-healthy diets are naturally low in dietary cholesterol and can help to reduce the risk of heart disease and stroke
Eating a heart-healthy dietary pattern rich in vegetables, fruits, whole grains, low-fat dairy products, poultry, fish, legumes, vegetable oils and nuts, which is also limits salt, red and processed meats, refined-carbohydrates and added sugars, is relatively low in dietary cholesterol and supports healthy levels of artery-clogging LDL cholesterol.

Pacemakers can improve heart function in patients with chemotherapy-induced heart disease
Research has shown that treating chemotherapy-induced cardiomyopathy with commercially available cardiac resynchronization therapy (CRT) delivered through a surgically implanted defibrillator or pacemaker can significantly improve patient outcomes.

Arsenic in drinking water may change heart structure raising risk of heart disease
Drinking water that is contaminated with arsenic may lead to thickening of the heart's main pumping chamber in young adults, according to a new study by researchers at Columbia University Mailman School of Public Health.

New health calculator can help predict heart disease risk, estimate heart age
A new online health calculator can help people determine their risk of heart disease, as well as their heart age, accounting for sociodemographic factors such as ethnicity, sense of belonging and education, as well as health status and lifestyle behaviors.

Wide variation in rate of death between VA hospitals for patients with heart disease, heart failure
Death rates for veterans with ischemic heart disease and chronic heart failure varied widely across the Veterans Affairs (VA) health care system from 2010 to 2014, which could suggest differences in the quality of cardiovascular health care provided by VA medical centers.

Heart failure: The Alzheimer's disease of the heart?
Similar to how protein clumps build up in the brain in people with some neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, protein clumps appear to accumulate in the diseased hearts of mice and people with heart failure, according to a team led by Johns Hopkins University researchers.

Read More: Heart Disease News and Heart Disease Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.