Nav: Home

Obesity may influence rheumatoid arthritis blood tests

April 10, 2017

New research reveals that in women, obesity may influence blood tests used to diagnose and monitor rheumatoid arthritis. The findings, which appear in Arthritis Care & Research, indicate that physicians need to take obesity into account when using these tests.

Blood tests for C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) can help physicians assess levels of inflammation in the body. The tests may be used for diagnosing rheumatoid arthritis and for determining how well treatment is working in affected patients.

Because some studies have found links between higher levels of CRP and ESR with greater body mass index (BMI), Michael George, MD MSCE, of the University of Pennsylvania Health System, and his colleagues sought to determine the extent to which obesity biases these markers. The researchers analyzed information on 2,103 individuals with rheumatoid arthritis and compared it with data from the general population.?

Among women with rheumatoid arthritis and in the general population, greater BMI was associated with greater CRP, especially among women with severe obesity. There was also a modest association between obesity and ESR in women. These links were also seen in men in the general population, but the connection between obesity and inflammation was different in men with rheumatoid arthritis. In these individuals, lower BMI was associated with greater CRP and ESR. This finding may be important for understanding the relationship between weight and inflammation and how it may differ between men and women.

"Our results suggest that obesity may lead to increased levels of CRP and ESR in women with rheumatoid arthritis," said Dr. George. "The increase in these levels of inflammation was not because rheumatoid arthritis was worse in these women. In fact, we found that obesity leads to very similar increases in these lab tests even in women without rheumatoid arthritis."

Dr. George noted that physicians need to be careful when interpreting these lab tests since both rheumatoid arthritis and obesity can contribute to levels of inflammation. "Physicians might assume that high levels of inflammation mean that a patient has rheumatoid arthritis or that their rheumatoid arthritis requires more treatment when in fact a mild increase in levels of inflammation could be due to obesity instead," he explained.
-end-


Wiley

Related Obesity Articles:

Changing the debate around obesity
The UK's National Health Service (NHS) needs to do more to address the ingrained stigma and discrimination faced by people with obesity, says a leading health psychologist.
Study links longer exposure to obesity and earlier development of obesity to increased risk of type 2 diabetes
Cumulative exposure to obesity could be at least as important as actually being obese in terms of risk of developing type 2 diabetes (T2D), concludes new research published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]).
How much do obesity and addictions overlap?
A large analysis of personality studies has found that people with obesity behave somewhat like people with addictions to alcohol or drugs.
Should obesity be recognized as a disease?
With obesity now affecting almost a third (29%) of the population in England, and expected to rise to 35% by 2030, should we now recognize it as a disease?
Is obesity associated with risk of pediatric MS?
A single-center study of 453 children in Germany with multiple sclerosis (MS) investigated the association of obesity with pediatric MS risk and with the response of first-line therapy in children with MS.
Women with obesity prior to conception are more likely to have children with obesity
A systematic review and meta-analysis identified significantly increased odds of child obesity when mothers have obesity before conception, according to a study published June 11, 2019 in the open-access journal PLOS Medicine by Nicola Heslehurst of Newcastle University in the UK, and colleagues.
Obesity medicine association announces major updates to its adult obesity algorithm
The Obesity Medicine Association (OMA) announced the immediate availability of the 2019 OMA Adult Obesity Algorithm, with new information for clinicians including the relationship between Obesity and Cardiovascular Disease, Diabetes Mellitus, Dyslipidemia, and Cancer; information on investigational Anti-Obesity Pharmacotherapy; treatments for Lipodystrophy; and Pharmacokinetics and Obesity.
Systematic review shows risk of a child developing overweight or obesity is more than trebled by maternal obesity prior to pregnancy
New research presented at this year's European Congress on Obesity (ECO) in Glasgow, Scotland (April 28- May 1) reveals that the risk of a child becoming overweight or obese is more than trebled by maternal obesity prior to getting pregnant.
Eating later in the day may be associated with obesity
Eating later in the day may contribute to weight gain, according to a new study to be presented Saturday at ENDO 2019, the Endocrine Society's annual meeting in New Orleans, La.
How obesity affects vitamin D metabolism
A new Journal of Bone and Mineral Research study confirms that vitamin D supplementation is less effective in the presence of obesity, and it uncovers a biological mechanism to explain this observation.
More Obesity News and Obesity Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Listen Again: Reinvention
Change is hard, but it's also an opportunity to discover and reimagine what you thought you knew. From our economy, to music, to even ourselves–this hour TED speakers explore the power of reinvention. Guests include OK Go lead singer Damian Kulash Jr., former college gymnastics coach Valorie Kondos Field, Stockton Mayor Michael Tubbs, and entrepreneur Nick Hanauer.
Now Playing: Science for the People

#562 Superbug to Bedside
By now we're all good and scared about antibiotic resistance, one of the many things coming to get us all. But there's good news, sort of. News antibiotics are coming out! How do they get tested? What does that kind of a trial look like and how does it happen? Host Bethany Brookeshire talks with Matt McCarthy, author of "Superbugs: The Race to Stop an Epidemic", about the ins and outs of testing a new antibiotic in the hospital.
Now Playing: Radiolab

Dispatch 6: Strange Times
Covid has disrupted the most basic routines of our days and nights. But in the middle of a conversation about how to fight the virus, we find a place impervious to the stalled plans and frenetic demands of the outside world. It's a very different kind of front line, where urgent work means moving slow, and time is marked out in tiny pre-planned steps. Then, on a walk through the woods, we consider how the tempo of our lives affects our minds and discover how the beats of biology shape our bodies. This episode was produced with help from Molly Webster and Tracie Hunte. Support Radiolab today at Radiolab.org/donate.