Nav: Home

Benefits and harms of osteoporosis medications unclear for patients with CKD

April 10, 2017

1. Benefits and harms of osteoporosis medications unclear for patients with CKD

Abstract: http://annals.org/aim/article/doi/10.7326/M16-2752

URL goes live when the embargo lifts

More research is needed to determine the benefits and harms of osteoporosis medications on bone mineral density (BMD), fracture risk, and safety among patients with chronic kidney disease (CKD). This is important because complications of CKD include weak bones and increased fracture risk. The results of a systematic review and meta-analysis are published in Annals of Internal Medicine.

Researchers at Johns Hopkins University Bloomberg School of Public Health in Baltimore, MD, reviewed published research to ascertain the benefits and harms of osteoporosis medications (bisphosphonates, teriparatide, raloxifene, and denosumab) compared with placebo, usual care, or active control in terms of bone mineral density (BMD), fractures, and safety in patients with CKD. Evidence showed that bisphosphonates may slow loss of BMD among transplant recipients, but their effects on fractures and safety in transplant recipients and others with CKD were not clear. Raloxifene may prevent vertebral fractures but may not improve BMD. Effects of teriparatide and denosumab on BMD and fractures were unclear and these medications may increase risk for some safety outcomes.

The authors concluded that more research is needed to determine the best options for patients across the spectrum of CKD to improve BMD and prevent fractures with minimal risk for diverse outcomes.

Media contacts: For an embargoed PDF, please contact Cara Graeff. To reach the lead author Lisa Willson, ScM, please contact Susan Murrow at smurrow1@jhu.edu or 410 955-7624.

2. Short, emergency department screening tool may help to identify youths at high risk for future firearm violence


The SaFETy score could be used to influence development of prevention and intervention efforts

Article: http://annals.org/aim/article/doi/10.7326/M16-1927

URL goes live when the embargo lifts

A short, in-office screening tool could be used as part of routine clinical care in urban settings to identify youths at high risk for future firearm violence. The results could be used to determine where to focus firearm violence prevention and intervention efforts. The study is published in Annals of Internal Medicine.

Interpersonal firearm violence among youth is a substantial public health problem, and emergency department (ED) physicians require a way to identify those at high risk. Researchers at the University of Michigan Injury Center in Ann Arbor, MI, used machine learning methods and data collected as part of the Flint Youth Injury Study to identify factors predictive of future firearm violence that could be incorporated into a brief clinical screening tool. A total of 599 substance-using youths, age 14 to 24 years, seeking ED care for an assault-related injury and a proportionately sampled group of non-assault-injured youth were followed over two years. The four domains that were most predictive of firearm violence were violence victimization, community exposure, peer influences, and fighting. The 10-point SaFETy (Serious fighting, Friend weapon carrying, community Environment, and firearm Threats) score was derived by selecting one item from each of the four domains. The researchers found that the SaFETy screening tool could be administered in 1 to 2 minutes and accurately defined a gradient of future firearm violence risk that could be adapted to a variety of settings. The info could also be used to inform prevention efforts.

Media contacts: For an embargoed PDF, please contact Cara Graeff. To speak with the lead author, Jason Goldstick, PhD, please contact Kylie O'Brien at kylieo@med.umich.edu or 734-764-2220. 3. Wrist-worn activity trackers offer inconsistent heart rate data

Abstract: http://annals.org/aim/article/doi/10.7326/L16-0353

URL goes live when the embargo lifts

Wrist-worn activity trackers that measure heart rate with a light-emitting diode offer inconsistent heart rate data. While current trackers may help to motivate people to engage in healthy behaviors, more research is needed before clinicians can use the data to advise patients about health issues or conduct clinical trials that require a high level of accuracy and reliability for heart rate measurement. The clinical observation is published in Annals of Internal Medicine.

Researchers at the University of Wisconsin in Madison, WI, studied 4 commercial, wrist-worn activity trackers to determine the accuracy of their heart rate monitoring. Study participants were 40 healthy consenting adults aged 30 to 65 without cardiovascular conditions. Each participant wore 2 trackers on each wrist in random order. Seated participants were then connected to an electrocardiograph to measure resting heart rate at one minute intervals for 10 minutes using the electrocardiograph and each of the 4 trackers. The measures were repeated while participants walked on the treadmill. Of the four commercial trackers tested, all performed better at rest than during moderately active exercise when compared with measures taken by electrocardiograph, and some of the activity trackers were more consistent than others.

Media contacts: For an embargoed PDF, please contact Cara Graeff. To speak with the lead author, Lisa Cadmus-Bertram, PhD, please contact Terry Devitt at trdevitt@wisc.edu or 608-262-8282.
-end-
Also new in this issue:

Botulinum Toxin for Burning Mouth Syndrome

Domenico A. Restivo, MD, PhD; Giuseppe Lauria, MD; Rosario Marchese-Ragona, MD; Riccardo Vigneri, MD

Clinical Observation

Abstract: http://annals.org/aim/article/doi/10.7326/L16-0451

American College of Physicians

Related Public Health Articles:

The Lancet Public Health: Ageism linked to poorer health in older people in England
Ageism may be linked with poorer health in older people in England, according to an observational study of over 7,500 people aged over 50 published in The Lancet Public Health journal.
Study: Public transportation use linked to better public health
Promoting robust public transportation systems may come with a bonus for public health -- lower obesity rates.
Bloomberg American Health Initiative releases special public health reports supplement
With US life expectancy now on the decline for two consecutive years, the Bloomberg American Health Initiative is releasing a supplement to Public Health Reports, the scholarly journal of the US Surgeon General.
Data does the heavy lifting: Encouraging new public health approaches to promote the health benefits of muscle-strengthening exercise (MSE)
According to a new study in the American Journal of Preventive Medicine, almost 75 percent of US adults do not comply with public health guidelines recommending two or more muscle-strengthening exercise (MSE) sessions a week, with nearly 60 percent of the population doing no MSE at all.
The Lancet Public Health: Moderate carbohydrate intake may be best for health
Low-carb diets that replace carbohydrates with proteins and fats from plant sources associated with lower risk of mortality compared to those that replace carbohydrates with proteins and fat from animal sources.
More Public Health News and Public Health Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Erasing The Stigma
Many of us either cope with mental illness or know someone who does. But we still have a hard time talking about it. This hour, TED speakers explore ways to push past — and even erase — the stigma. Guests include musician and comedian Jordan Raskopoulos, neuroscientist and psychiatrist Thomas Insel, psychiatrist Dixon Chibanda, anxiety and depression researcher Olivia Remes, and entrepreneur Sangu Delle.
Now Playing: Science for the People

#537 Science Journalism, Hold the Hype
Everyone's seen a piece of science getting over-exaggerated in the media. Most people would be quick to blame journalists and big media for getting in wrong. In many cases, you'd be right. But there's other sources of hype in science journalism. and one of them can be found in the humble, and little-known press release. We're talking with Chris Chambers about doing science about science journalism, and where the hype creeps in. Related links: The association between exaggeration in health related science news and academic press releases: retrospective observational study Claims of causality in health news: a randomised trial This...