The Olig family affects central nervous system development and disease

April 11, 2014

The oligodendrocyte transcription family (Olig family) is widely expressed in the central nervous system of various mammals, and plays a critical role in central nervous system development by controlling differentiation and maturation of oligodendrocytes, motor neurons and astrocytes. Moreover, accumulating evidence demonstrates Olig family participation in many central nervous system diseases. Therefore, based on current literature, Dr. Lehua Yu and co-workers from Second Affliated Hospital, Chongqing Medical University in China examine the role of the Olig family in central nervous system development and related diseases. The Olig family is known not only to be an important factor in regulating neural cell differentiation, but also affects acute and chronic central nervous system diseases, including brain injury, multiple sclerosis, and even gliomas. Improved understanding about the functions of the Olig family in central nervous system development and disease will greatly aid novel breakthroughs in central nervous system diseases. The relevant paper has been published in the Neural Regeneration Research (Vol. 9, No. 3, 2014).
Article: " The Olig family affects central nervous system development and disease" by Botao Tan, Jing Yu, Ying Yin, Gongwei Jia, Wei Jiang, Lehua Yu (Department of Rehabilitation Medicine, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China)

Tan BT, Yu J,Yin Y, Jia GW, Jiang W, Yu LH. The Olig family affects central nervous system development and disease. Neural Regen Res. 2014;9(3):329-336.

Contact: Meng Zhao 86-138-049-98773 Neural Regeneration Research

Neural Regeneration Research

Related Multiple Sclerosis Articles from Brightsurf:

New therapy improves treatment for multiple sclerosis
A new therapy that binds a cytokine to a blood protein shows potential in treating multiple sclerosis, and may even prevent it.

'Reelin' in a new treatment for multiple sclerosis
In an animal model of multiple sclerosis (MS), decreasing the amount of a protein made in the liver significantly protected against development of the disease's characteristic symptoms and promoted recovery in symptomatic animals, UTSW scientists report.

Not all multiple sclerosis-like diseases are alike
Scientists say some myelin-damaging disorders have a distinctive pathology that groups them into a unique disease entity.

New therapeutic options for multiple sclerosis in sight
Strategies for treating multiple sclerosis have so far focused primarily on T and B cells.

Diet has an impact on the multiple sclerosis disease course
The short-chain fatty acid propionic acid influences the intestine-mediated immune regulation in people with multiple sclerosis (MS).

The gut may be involved in the development of multiple sclerosis
It is incompletely understood which factors in patients with multiple sclerosis act as a trigger for the immune system to attack the brain and spinal cord.

Slowing the progression of multiple sclerosis
Over 77,000 Canadians are living with multiple sclerosis, a disease whose causes still remain unknown.

7T MRI offers new insights into multiple sclerosis
Investigators from Brigham and Women's Hospital have completed a new study using 7 Tesla (7T) MRI -- a far more powerful imaging technology -- to further examine LME in MS patients

How to improve multiple sclerosis therapy
Medications currently used to treat multiple sclerosis (MS) can merely reduce relapses during the initial relapsing-remitting phase.

Vaccinations not a risk factor for multiple sclerosis
Data from over 12,000 multiple sclerosis (MS) patients formed the basis of a study by the Technical University of Munich (TUM) which investigated the population's vaccination behavior in relation to MS.

Read More: Multiple Sclerosis News and Multiple Sclerosis Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to