Nav: Home

Metabolic mechanism identified for R-LA induced cell death in liver cancer cells

April 11, 2017

New Rochelle, NY, April 11, 2017--A new study that measured metabolite levels over time in starved rat liver cancer cells showed that treatment with a form of alpha-lipoic acid (LA) inhibited glucose uptake and glycolysis, and led to decreased cellular glucose production from non-carbohydrate sources, which may help explain how the naturally occurring R enantiomeric form of LA (R-LA) promotes the death of hepatoma cells. Researchers supported their findings with measurements of amino acid metabolism and lactic acid production in R-LA and untreated hepatoma cells, as reported in Journal of Medicinal Food, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Journal of Medicinal Food website until May 11, 2017.

LA is a powerful antioxidant and R-LA is an essential cofactor in cellular energy metabolism. Naoko Ikuta, Seiichi Matsugo, and coauthors from Graduate School of Medicine, Kobe University, Kanazawa University, and CycloChem Bio Co. (Kobe), Japan, and University of Kiel, Germany, demonstrated that concentrations of the amino acids glycine, threonine, and serine, were significantly lower in R-LA treated rat hepatoma cells compared to in untreated cells or cells treated with the D-enantiomeric form of LA (D-LA). This indicates down-regulation of the Thr-Gly-Ser pathways and associated inhibition of gluconeogenesis from protein sources, as described in the article entitled "Time Course Effect of R-Alpha-Lipoic Acid on Cellular Metabolomics in Cultured Hepatoma Cells."
-end-
About the Journal

Journal of Medicinal Food is an authoritative, peer-reviewed, multidisciplinary journal published monthly online with open access options and in print. Led by Editors-in-Chief Sampath Parthasarathy, MBA, PhD, Florida Hospital Chair in Cardiovascular Sciences and Interim Associate Dean, College of Medicine, University of Central Florida, and Yangha Kim, PhD, Ewha Womans University, Seoul, South Korea, the Journal publishes original scientific research on the bioactive substances of functional and medicinal foods, nutraceuticals, herbal substances, and other natural products. The Journal explores the chemistry and biochemistry of these substances, as well as the methods for their extraction and analysis, the use of biomarkers and other methods to assay their biological roles, and the development of bioactive substances for commercial use. Tables of content and a sample issue may be viewed on the Journal of Medicinal Food website.

About the Publisher

Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including The Journal of Alternative and Complementary Medicine and Cannabis and Cannabinoid Research. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.

Mary Ann Liebert, Inc./Genetic Engineering News

Related Death Articles:

Risk of death from stroke falls by 24%
Thousands more patients each year are surviving strokes, as the risk of death and disability after a stroke fell significantly between 2000 and 2015, according to analysis by Guy's and St Thomas' researchers.
Cells control their dance of death
La Trobe University researchers have revealed for the first time how white blood cells control the final moments of their death, helping their own removal from the human body.
Predicting frailty, disability and death
In a study led by investigators from Brigham and Women's Hospital, researchers analyzed patterns of movement among elderly study participants and found that irregular, spontaneous fluctuations could predict a person's risk of frailty, disability and death years later.
One in 10 people have 'near-death' experiences, according to new study
The new findings were presented at the 5th European Academy of Neurology (EAN) Congress.
Jobs vs. death toll: Calculating corporate death penalties
What misdeeds warrant corporate death penalties? A new study explores two case studies focused on industries that kill more people than they employ.
New role for death molecule
To unravel programmed cell death pathways, investigators examine a molecule deemed unimportant, and find new function.
Death near the shoreline, not life on land
Our understanding of when the very first animals started living on land is helped by identifying trace fossils--the tracks and trails left by ancient animals--in sedimentary rocks that were deposited on the continents.
Fine-tuning cell death: New component of death machinery revealed
An important component of the microscopic machinery that drives cell death has been identified by Australian scientists.
Slow death of nearby galaxy
Astronomers from CSIRO and The Australian National University have witnessed, in the finest detail ever, the slow death of a neighbouring dwarf galaxy, which is gradually losing its power to form stars.
The world needs death and decomposition
Thanks to a new study by Michigan State University, scientists now have a better way to investigate decomposing plants' and animals' contributions to the ecosystem.
More Death News and Death Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Climate Mindset
In the past few months, human beings have come together to fight a global threat. This hour, TED speakers explore how our response can be the catalyst to fight another global crisis: climate change. Guests include political strategist Tom Rivett-Carnac, diplomat Christiana Figueres, climate justice activist Xiye Bastida, and writer, illustrator, and artist Oliver Jeffers.
Now Playing: Science for the People

#562 Superbug to Bedside
By now we're all good and scared about antibiotic resistance, one of the many things coming to get us all. But there's good news, sort of. News antibiotics are coming out! How do they get tested? What does that kind of a trial look like and how does it happen? Host Bethany Brookeshire talks with Matt McCarthy, author of "Superbugs: The Race to Stop an Epidemic", about the ins and outs of testing a new antibiotic in the hospital.
Now Playing: Radiolab

Speedy Beet
There are few musical moments more well-worn than the first four notes of Beethoven's Fifth Symphony. But in this short, we find out that Beethoven might have made a last-ditch effort to keep his music from ever feeling familiar, to keep pushing his listeners to a kind of psychological limit. Big thanks to our Brooklyn Philharmonic musicians: Deborah Buck and Suzy Perelman on violin, Arash Amini on cello, and Ah Ling Neu on viola. And check out The First Four Notes, Matthew Guerrieri's book on Beethoven's Fifth. Support Radiolab today at Radiolab.org/donate.