Nav: Home

All pooped out -- this is how norovirus does it

April 12, 2018

Researchers have long sought to identify the cells in the gut that are susceptible to infection by norovirus, the leading cause of viral gastroenteritis worldwide - and now one team has pinpointed the type of cell that falls victim. The finding could eventually lead to a therapy for this troublesome virus that infects 700 million people annually, causing symptoms such as diarrhea, vomiting, abdominal pain and in some cases death. In previous work, Craig B. Wilen and colleagues discovered that noroviruses use the receptor CD300lf to infect cells. However, this receptor is mostly thought to be expressed in blood stem cells, not cells lining the gut, where noroviruses take hold. Here, the team fluorescently marked CD300lf-expressing cells throughout the ilea and colons of mice, homing in a small subset called tuft cells, a rare chemosensory epithelial cell type found in both mice and humans. In analyzing millions of cells, the researchers found that norovirus infects tuft cells, but not regular epithelial cells in the gut. Reproduction of tuft cells is known to be boosted in the presence of two immune signaling proteins, IL-4 and IL-25, prompting Wilen et al. to assess whether these proteins facilitate the transmission of noroviruses in mice. Indeed, they found that administering both IL-4 and IL-25 significantly increased both the proportion of mice infected with virus and the abundance of viral particles within feces.
-end-


American Association for the Advancement of Science

Related Norovirus Articles:

Protein associated with Parkinson's disease linked to human upper GI tract infections
Acute and chronic infections in a person's upper gastrointestinal tract appear to be linked to Parkinson's disease, say scientists at Georgetown University Medical Center and their collaborators at the National Institutes of Health and other institutions.
Ben-Gurion U. researchers develop membranes that remove viruses from drinking water
The 'zwitterionic polymer hydrogel' repels the viruses from approaching and passing through the membrane.
Five fast facts about norovirus
Cruise ships, nursing homes, and daycare centers are common breeding grounds for norovirus, a contagious stomach bug that infects 685 million people around the world each year.
Scientists succeed at growing noroviruses in human intestinal cell cultures in the lab
The USDA's National Institute of Food and Agriculture supports NoroCORE, a multidisciplinary research collaborative of 30 researchers from 25 universities who are joining forces to understand and control foodborne virus risks.
NIH-supported researchers develop novel system to grow norovirus in intestinal cells
Researchers have succeeded in culturing norovirus in human intestinal cells, a breakthrough that could help scientists develop novel therapeutics and vaccines against the debilitating effects of the virus.
Solving a 48-year-old mystery: Scientists grow noroviruses in human intestinal cell cultures
For the first time, scientists have grown human noroviruses, the leading viral cause of acute diarrhea worldwide, in human intestinal cell cultures in the lab.
New clues found to how 'cruise-ship' virus gets inside cells
Researchers at Washington University School of Medicine in St. Louis have identified the protein that norovirus uses to invade cells.
Luminous proteins offer new method to discover viral infections
Researchers at Umeå University have developed a new method to directly follow viral infections in living organisms.
Mille-feuille-filter removes viruses from water
A simple paper sheet made by scientists at Uppsala University can improve the quality of life for millions of people by removing resistant viruses from water.
The $60 billion question -- can we prevent norovirus?
Each year, norovirus causes over 200,000 deaths and a global economic burden of $60 billion.

Related Norovirus Reading:

Norovirus: How to Stay Safe (Consumer Health Guides Book 2)
by Eternal Spiral Books, http://EternalSpiralBooks.com

++Tenth edition, published July 1, 2014, now available to download.++

Norovirus is commonly called 'food poisoning' or 'stomach flu'. It causes over 21 million cases of stomach upset (gastroenteritis) every year in the United States and more than 800 deaths. As of January 2013, however, a whole new strain of Norovirus began sweeping throughout the globe and spreading from coast to coast in the United States, and is continuing to spread and even mutate in 2014.

In this report, popular health writer Carolyn Stone gives you the essentials on Norovirus: what it is, where it... View Details


The Norovirus: Features, Detection, and Prevention of Foodborne Disease
by Paul K S Chan (Editor), Hoi Shan Kwan (Editor), Martin C.W. Chan (Editor)

The Norovirus: Features, Detection and Prevention of Foodborne Disease is a unique and valuable reference for both researchers in industry and students who need to understand how this specific pathogen behaves in order to improve control of food as a transmission of this infectious biological agent.

The information in the book provides essential, specific information to help further understand potential new strains of the pathogen, offering detection analysis and prevention strategies of the pathogen to assist in combatting the spread of foodborne illness. Written by... View Details


Norovirus: Webster's Timeline History, 2002 - 2007
by Icon Group International (Author)

Webster's bibliographic and event-based timelines are comprehensive in scope, covering virtually all topics, geographic locations and people. They do so from a linguistic point of view, and in the case of this book, the focus is on "Norovirus," including when used in literature (e.g. all authors that might have Norovirus in their name). As such, this book represents the largest compilation of timeline events associated with Norovirus when it is used in proper noun form. Webster's timelines cover bibliographic citations, patented inventions, as well as non-conventional and alternative meanings... View Details


21st Century Complete Medical Guide to Gastroenteritis, Norwalk Virus, Norovirus, Authoritative Government Documents, Clinical References, and ... for Patients and Physicians (CD-ROM)
by PM Medical Health News (Author)

This up-to-date electronic book on CD-ROM provides the best collection available anywhere of official Federal government information and documents on the subject of gastroenteritis, diarrhea, Norwalk virus, and the norovirus family. This CD-ROM uses next-generation search technology that allows complete indexing and makes all files on the disc fully searchable. For patients, practical information is provided in clearly written patient education documents. For medical professionals, doctor reference tools and texts have detailed technical information and clinical background material.

This... View Details


Hand Hygiene: A Handbook for Medical Professionals (Hospital Medicine: Current Concepts)
by Didier Pittet (Editor), John M. Boyce (Editor), Benedetta Allegranzi (Editor)

The first comprehensive, authoritative review of one of the most fundamental and important issues in infection control and patient safety, hand hygiene. Developed and presented by the world's leading scholar-clinicians, Hand Hygiene is an essential resource for all medical professionals.
Developed and presented by the world leaders in this fundamental topic  Fully integrates World Health Organization (WHO) guidelines and policies Offers a global perspective in tackling hand hygiene issues in developed and developing countries Coverage of basic and highly complex clinical... View Details


Studies on Norovirus for a higher protection of human life and health
by Ventrone Iole (Author)

Norovirus in shellfish are the main cause of human gastroenteritis outbreaks worldwide. So Commission Regulation (EC) No 2073/2005 on microbiological criteria for foodstuffs gave attention to shellfish safety criteria. In order to establish the purification times, in addition to the conventional bacterial fecal indicators is necessary demonstrating the presence of NLVs by harmonized sampling frequencies at Community level. Finally it's confirmed the need of new safety criteria for pathogenic viruses in live bivalve molluscs by official analytical methods. The official method to research... View Details


Norovirus - Heilen mit Naturheilkunde und Schulmedizin (German Edition)
by Eva Marbach Verlag

Der Norovirus ist in den letzten Jahren zum Schreckgespenst
aller Restaurants, Kantinen, Kreuzfahrtschiffe, Krankenhäuser, Kindergärten und Schulen geworden.

Die hochansteckende Magen-Darm-Infektion wirft jedes Jahr tausende von Menschen
mit unvermittelter Plötzlichkeit aufs Krankenbett und quält die Betroffenen für mehrere Tage mit Erbrechen und Durchfall.
Wenn man sich auf die Gefahr durch den Norovirus einstellt
kann man eine Infektion durch geeignete Vorbeuge-Maßnahmen verhindern.
Falls es einen doch erwischt, ist es wichtig zu wissen,
was... View Details


Lebensmittelassoziierte Viren - Norovirus
b

View Details


Gnotobiotics (American College of Laboratory Animal Medicine)
by Trenton R Schoeb (Editor), Kathryn A Eaton (Editor)

Gnotobiotics summarizes and analyzes the research conducted on the use of gnotobiotes, providing detailed information regarding actual facility operation and derivation of gnotobiotic animals.

In response to the development of new tools for microbiota and microbiome analysis, the increasing recognition of the various roles of microbiota in health and disease, and the consequent expanding demand for gnotobiotic animals for microbiota/microbiome related research, this volume collates the research of this expanding field into one definitive resource.

Reviews and defines... View Details


Think Zebras
by Kathryn D. Scott (Author)

A lowly virus, a disturbed mind, and an internal power struggle. A common illness is killing the elderly in Revere County, but Mary Campbell, the nurse supervisor for the understaffed Communicable Disease Control Unit, is told not to worry. The increase in outbreaks is likely due to a new strain of the virus circulating in the United States. But something feels wrong. Mary senses she’s overlooking an important link. To uncover the connection, she reluctantly embraces a new strategy suggested by her department’s maligned bioterrorism coordinator. Set two years after the 9/11 attacks,... View Details

Best Science Podcasts 2018

We have hand picked the best science podcasts for 2018. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Turning Kids Into Grown-Ups
Parenting is fraught with uncertainty, changing with each generation. This hour, TED speakers share ideas about raising kids and how — despite our best efforts — we're probably still doing it wrong. Guests include former Stanford dean Julie Lythcott-Haims, former firefighter Caroline Paul, author Peggy Orenstein, psychologist Dr. Aala El-Khani, and poet Sarah Kay.
Now Playing: Science for the People

#470 Information Spookyhighway
This week we take a closer look at a few of the downsides of the modern internet, and some of the security and privacy challenges that are becoming increasingly troublesome. Rachelle Saunders speaks with cyber security expert James Lyne about how modern hacking differs from the hacks of old, and how an internet without national boards makes it tricky to police online crime across jurisdictions. And Bethany Brookshire speaks with David Garcia, a computer scientist at the Complexity Science Hub and the Medical University of Vienna, about the recent Cambridge Analytica scandal, and how social media platforms put a wrench...