Nav: Home

Kidney disease is a major cause of cardiovascular deaths

April 13, 2017

Highlights
  • In 2013, reduced kidney function was associated with 4% of deaths worldwide, or 2.2 million deaths.
  • More than half of these deaths were cardiovascular deaths.
  • Maintaining kidney health may help prevent cardiovascular diseases and deaths.

Washington, DC (April 13, 2017) -- A new analysis indicates that by 2013, cardiovascular deaths attributed to reduced kidney function outnumbered kidney failure deaths throughout the world. The findings, which appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN), provide insights on the true impact of kidney disease on societies and underscore the importance of screening for kidney disease.

Reduced kidney function can have detrimental effects on cardiovascular health, increasing individuals' risks of congestive heart failure, heart attacks, and strokes. To understand the impact of chronic kidney disease (CKD) on cardiovascular health, Bernadette Thomas MD, MS (University of Washington), along with dozens of international collaborators as well as the International Society of Nephrology and the Chronic Kidney Disease Prognosis Consortium, estimated the prevalence of reduced kidney function categories (CKD stages 3, 4, and 5) for 188 countries at 6 time points from 1990 to 2013 as part of the Global Burden of Disease Study.

The investigators estimated that in 2013, reduced kidney function was associated with 4% of deaths worldwide, or 2.2 million deaths. More than half (1.2 million) of these attributable deaths were cardiovascular deaths, while 0.96 million were deaths from kidney failure. Compared with metabolic risk factors, reduced kidney function ranked below high systolic blood pressure, high body mass index, and high fasting blood sugar and similarly with high total cholesterol as a risk factor for disability-adjusted life years (the number of years lost due to ill-health, disability, or early death) in both developed and developing world regions.

"Understanding the true health impact of kidney disease on society necessitates considering cardiovascular as well as end-stage renal disease deaths and disability," said Dr. Thomas. "This is especially important within the developing world, where the death rate has increased since 1990."
-end-
Study co-authors include Kunihiro Matsushita,Kalkidan Hassen Abate, Ziyad Al-Aly, Johan Arnlov, Kei Asayama, Robert Atkins, Alaa Badawi Shoshana H. Ballew, Amitava Banerjee, Lars Barregard,Elizabeth Barrett-Connor, Sanjay Basu, Aminu Bello, Isabela Bensenor, Jaclyn Bergstrom, Boris Bikbov, Christopher Blosser, Hermann Brenner, Juan-Jesus Carrero, Steve Chadban, Massimo Cirillo, Monica Cortinovis Karen Courville de Vaccaro, Lalit Dandona,* Rakhi Dandona, Kara Estep, Joao Fernandes, Florian Fischer, Caroline Fox, Ron T. Gansevoort, Phil Gona, Orlando M. Gutierrez, Samer Hamidi, Sarah Hanson, Jonathan Himmelfarb, Simerjot K. Jassal, Sun Ha Jee, Vivekanand Jha, Aida Jimenez-Corona, Jost B. Jonas, Andre Pascal Kengne, Yousef Khader, Young-Ho Khang, Yun Jin Kim, Barbara E. K. Klein, Ronald Klein, Yoshihiro Kokubo, Dhaval Kolte, Kristine Lee, Andrew S. Levey, Yongmei Li, Paulo Lotufo, Hassan Magdy Abd El Razek,* Walter Mendoza, Hirohito Metoki, Yejin Mok, Isao Muraki, Paul M. Muntner, Hiroyuki Noda, Takayoshi Ohkubo, Alberto Ortiz, Norberto Perico, Kevan Polkinghorne, Rajaa Raddadi, Giuseppe Remuzzi, Gregory Roth, Dietrich Rothenbacher, Michihiro Satoh, Kai-Uwe Saum, Monika Sawhney, Ben Schöttker, Anoop Shankar, Michael Shlipak, Diego Augusto Santos Silva, Hideaki Toyoshima, Kingsley Ukwaja, Mitsumasa Umesawa, Stein Emil Vollset, David G. Warnock, Andrea Werdecker, Kazumasa Yamagishi, Yuichiro Yano, Naohiro Yonemoto, Maysaa El Sayed Zaki, Mohsen Naghavi, Mohammad H. Forouzanfar, Christopher J.L. Murray, Josef Coresh, and Theo Vos.

Disclosures: The authors reported no financial disclosures.

The article, entitled "Worldwide cardiovascular and ESRD outcomes attributable to reduced GFR," will appear online at http://jasn.asnjournals.org/ on April 13, 2017, doi: 10.1681/ASN.2016050562.

The content of this article does not reflect the views or opinions of The American Society of Nephrology (ASN). Responsibility for the information and views expressed therein lies entirely with the author(s). ASN does not offer medical advice. All content in ASN publications is for informational purposes only, and is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This content should not be used during a medical emergency or for the diagnosis or treatment of any medical condition. Please consult your doctor or other qualified health care provider if you have any questions about a medical condition, or before taking any drug, changing your diet or commencing or discontinuing any course of treatment. Do not ignore or delay obtaining professional medical advice because of information accessed through ASN. Call 911 or your doctor for all medical emergencies.

Since 1966, ASN has been leading the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients. ASN has nearly 17,000 members representing 112 countries. For more information, please visit http://www.asn-online.org or contact the society at 202-640-4660.

American Society of Nephrology

Related Kidney Disease Articles:

Predicting risk of chronic kidney disease
Data from about 5 million people (with and without diabetes) in 28 countries were used to develop equations to help identify people at increased five-year risk of chronic kidney disease, defined as reduced estimated glomerular filtration rate (eGFR).
A healthy diet may help prevent kidney disease
In an analysis of published studies, a healthy dietary pattern was associated with a 30% lower incidence of chronic kidney disease.
Is kidney failure a man's disease?
A new analysis of the ERA-EDTA Registry [1] reveals a striking gender difference in the incidence and prevalence of end-stage renal disease.
Chronic kidney disease: Everyone's concern
850 million people worldwide are affected by kidney disease. This worrying figure was published last June.
Revealed: 35 kidney genes linked to chronic kidney disease risk
An international study lead by University of Manchester scientists has discovered the identity of genes that predispose people to chronic kidney disease.
Gene editing possible for kidney disease
For the first time scientists have identified how to halt kidney disease in a life-limiting genetic condition, which may pave the way for personalised treatment in the future.
Kidney disease biomarker may also be a marker for COPD
A commonly used biomarker of kidney disease may also indicate lung problems, particularly COPD, or chronic obstructive pulmonary disease, according to new research published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.
In kidney disease patients, illicit drug use linked with disease progression and death
Among individuals with chronic kidney disease, hard illicit drug use was associated with higher risks of kidney disease progression and early death.
Drinking more water does not slow decline of kidney function for kidney disease patients
A new study, published in JAMA by researchers at Lawson Health Research Institute and Western University, found that coaching patients with Chronic Kidney Disease (CKD) to drink more water does not slow down the decline of their kidney function.
Obesity surgery prevents severe chronic kidney disease and kidney failure
Patients that underwent weight-loss surgery ran a significantly lower risk of developing severe chronic kidney disease and kidney failure, when compared to conventionally treated patients, according to a study published in International Journal of Obesity.
More Kidney Disease News and Kidney Disease Current Events

Top Science Podcasts

We have hand picked the top science podcasts of 2019.
Now Playing: TED Radio Hour

Risk
Why do we revere risk-takers, even when their actions terrify us? Why are some better at taking risks than others? This hour, TED speakers explore the alluring, dangerous, and calculated sides of risk. Guests include professional rock climber Alex Honnold, economist Mariana Mazzucato, psychology researcher Kashfia Rahman, structural engineer and bridge designer Ian Firth, and risk intelligence expert Dylan Evans.
Now Playing: Science for the People

#541 Wayfinding
These days when we want to know where we are or how to get where we want to go, most of us will pull out a smart phone with a built-in GPS and map app. Some of us old timers might still use an old school paper map from time to time. But we didn't always used to lean so heavily on maps and technology, and in some remote places of the world some people still navigate and wayfind their way without the aid of these tools... and in some cases do better without them. This week, host Rachelle Saunders...
Now Playing: Radiolab

Dolly Parton's America: Neon Moss
Today on Radiolab, we're bringing you the fourth episode of Jad's special series, Dolly Parton's America. In this episode, Jad goes back up the mountain to visit Dolly's actual Tennessee mountain home, where she tells stories about her first trips out of the holler. Back on the mountaintop, standing under the rain by the Little Pigeon River, the trip triggers memories of Jad's first visit to his father's childhood home, and opens the gateway to dizzying stories of music and migration. Support Radiolab today at Radiolab.org/donate.