A potential breakthrough in obesity medicine with the help of gold nanoparticles

April 14, 2020

A team of researchers in Korea believes to have discovered a synthetic gold-based compound which may help patients with obesity. The team led by Sunoh Kim, Deok-Chun Yang at Bioresources and Technology and Kyung Hee University, South Korea, respectively, investigated the anti-lipid accumulation effect of spherical gold nanoparticles (10-20 nm in size) synthesized from Dendropanax morbifera Léveille - a shrub which is endemic to the Korean peninsula. The nanoparticles, dubbed D-AuNPs, were tested in both 3T3-L1 and HepG2 cell lines, which are two known candidates for studying obesity and related disease models.

Research into gold nanoparticles is increasingly gaining the attention of researchers due to a rare combination of their potential medicinal benefits and environmental friendly implications. The team introduced a cocktail of the synthetic compound into 3T3-L1 preadipocytes and HepG2 hepatocytes.

"We found that the gold nanoparticles were nontoxic to 3T3-L1 at concentrations up to 100 μg/ml and HepG2 at post-confluent and mature stages," says Kim. Additionally, the team found that adipogenesis, the process that is responsible for the formation of fat cells, was inhibited. This inhibition was also companied by reduced concentrations of key metabolites and downregulation of genetic expression of the key proteins required for adipogenesis.

"We hypothesize that Dendropanax contains a large amount of phenolic compounds that coats the surface of gold nanoparticles and has the ability to reduce the excess amount of lipid in both cell lines.," add Kim.
Keywords: Gold nanoparticles, obesity, Dendropanax morbifera Léveille, PPARγ, 3T3-L1 and HepG2 cell lines.

For further information, please visit: http://www.eurekaselect.com/node/178364

Bentham Science Publishers

Related Obesity Articles from Brightsurf:

11 years of data add to the evidence for using testosterone therapy to treat obesity, including as an alternative to obesity surgery
New research covering 11 years of data presented at this year's European and International Congress on Obesity (ECOICO 2020) show that, in obese men suffering from hypogonadism (low testosterone), treatment with testosterone injections lowers their weight and improves a wide range of other metabolic parameters.

Overlap between immunology of COVID-19 and obesity could explain the increased risk of death in people living with obesity, and also older patients
Data presented in a special COVID-19 session at the European and International Congress on Obesity (ECOICO 2020) suggests that there are overlaps between the immunological disturbances found in both COVID-19 disease and patients with obesity, which could explain the increased disease severity and mortality risk faced by obese patients, and also elderly patients, who are infected by the SARS-CoV-2 virus that causes COVID-19 disease.

New obesity guideline: Address root causes as foundation of obesity management
besity management should focus on outcomes that patients consider to be important, not weight loss alone, and include a holistic approach that addresses the root causes of obesity, according to a new clinical practice guideline published in CMAJ (Canadian Medical Association Journal) http://www.cmaj.ca/lookup/doi/10.1503/cmaj.191707.

Changing the debate around obesity
The UK's National Health Service (NHS) needs to do more to address the ingrained stigma and discrimination faced by people with obesity, says a leading health psychologist.

Study links longer exposure to obesity and earlier development of obesity to increased risk of type 2 diabetes
Cumulative exposure to obesity could be at least as important as actually being obese in terms of risk of developing type 2 diabetes (T2D), concludes new research published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]).

How much do obesity and addictions overlap?
A large analysis of personality studies has found that people with obesity behave somewhat like people with addictions to alcohol or drugs.

Should obesity be recognized as a disease?
With obesity now affecting almost a third (29%) of the population in England, and expected to rise to 35% by 2030, should we now recognize it as a disease?

Is obesity associated with risk of pediatric MS?
A single-center study of 453 children in Germany with multiple sclerosis (MS) investigated the association of obesity with pediatric MS risk and with the response of first-line therapy in children with MS.

Women with obesity prior to conception are more likely to have children with obesity
A systematic review and meta-analysis identified significantly increased odds of child obesity when mothers have obesity before conception, according to a study published June 11, 2019 in the open-access journal PLOS Medicine by Nicola Heslehurst of Newcastle University in the UK, and colleagues.

Obesity medicine association announces major updates to its adult obesity algorithm
The Obesity Medicine Association (OMA) announced the immediate availability of the 2019 OMA Adult Obesity Algorithm, with new information for clinicians including the relationship between Obesity and Cardiovascular Disease, Diabetes Mellitus, Dyslipidemia, and Cancer; information on investigational Anti-Obesity Pharmacotherapy; treatments for Lipodystrophy; and Pharmacokinetics and Obesity.

Read More: Obesity News and Obesity Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.