Probiotic intervention in ameliorating the altered CNS functions in neurological disorders

April 15, 2020

As per the WHO report, one in every four people are affected by a mental or neurological disorder at some point in their lives making mental disorders among the leading cause of ill-health and disability worldwide. In the present era of socioeconomic competition and related stress, there has been a significant rise in the incidence of neurological and psychiatric ailments especially depression, bipolar disorder, acute anxiety and panic attacks. Many of these conditions are actually never talked about openly as people (affected directly or indirectly) shy away or feel embarrassed, causing the worsening of the conditions of a directly affected person in the absence of proper and early diagnosis and treatment.

With this scenario, the need to investigate newer and safer intervention therapies with prophylactic and/or therapeutic effects is well understood. Recently, the role of gut microbiota and its cross-talk with the human brain in modulating Central Nervous System (CNS) physiology and its optimal working has been highlighted. This review article, presented by Sharma and Kaur (Mehr Chand Mahajan DAV College for Women, India), focuses on the role and effect of regular intake of probiotic bacteria (through external administration of probiotic rich foods, drinks, capsules etc.) that help to strengthen our overall gut health. The review gives a comprehensive insight into the potential of regular intake of these good bacteria in a fixed dose to strengthen our gut microflora thus improving neurologic manifestations or decreasing the incidence and severity of neurological and psychiatric disorders. It also delineates the underlying mechanisms involved at the molecular and biochemical level through which the probiotic bacteria work in ameliorating the altered CNS functions under diseased neurological and psychiatric disorders (Anxiety, Major Depressive disorder, bipolar disorder, schizophrenia, autism spectrum disorder, cognitive impairments etc). The potential of probiotics as an important dietary modification as well as a useful intervention therapy with preventive and therapeutic value holds strong and should be an integral part of other treatment protocols recommended for the target population by the physician.
The article is published as Open Access (Free to read and download). To access the Full-text article please visit:

Bentham Science Publishers

Related Bipolar Disorder Articles from Brightsurf:

Amygdala changes in male patients with schizophrenia and bipolar disorder
Researchers in Japan have revealed that DNA methylation occurs in the serotonin transporter gene that regulates neurotransmitter transmission in schizophrenia and bipolar patients.

Effect of high-deductible insurance use in bipolar disorder
A new study led by the Department of Population Medicine finds that individuals with bipolar disorder who switched to high-deductible health plans (HDHPs) experienced a moderate decrease in nonpsychiatrist mental health outpatient visits, but rates of psychiatrist visits, medication use, emergency department visits, and hospitalizations did not change.

Is bipolar disorder associated with increased risk of Parkinson's disease?
This study, called a systematic review and meta-analysis, combined the results of seven studies with 4.3 million participants to examine a potential association between bipolar disorder with a later diagnosis of Parkinson's disease of unknown cause.

Bipolar disorder may be linked to Parkinson's disease
People who have bipolar disorder may be more likely to later develop Parkinson's disease than people who do not have bipolar disorder, according at a study published in the May 22, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Probiotics could help millions of patients suffering from bipolar disorder
About 3 million people in the US are diagnosed every year with bipolar disorder, a psychiatric condition characterized by dramatic shifts in mood from depression to mania.

Novel intervention for anxiety symptoms among people with Bipolar Disorder
Psychologists at Lancaster University have devised a novel psychological intervention to address Anxiety in Bipolar Disorder (AIBD).

Mutation links bipolar disorder to mitochondrial disease
Mutations in the gene ANT1 may confer a risk for bipolar disorder through a complex interplay between serotonin and mitochondrial signaling in the brain.

A new path into bipolar disorder comes to light
A new article authored by an international group of researchers reveals a novel potential drug target for bipolar disorder and offers new insights into the underlying biology of this lifelong and devastating mental illness.

After searching 12 years for bipolar disorder's cause, U-M team concludes it has many
Nearly 6 million Americans have bipolar disorder, and most have probably wondered why.

Simple EKG can determine whether patient has depression or bipolar disorder
A groundbreaking Loyola Medicine study suggests that a simple 15-minute electrocardiogram could help a physician determine whether a patient has major depression or bipolar disorder.

Read More: Bipolar Disorder News and Bipolar Disorder Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to