Hope for new treatment of severe epilepsy

April 16, 2018

Researchers at Lund University in Sweden believe they have found a method that in the future could help people suffering from epilepsy so severe that all current treatment is ineffective.

"In mice studies, we succeeded in reducing seizure activity by intervening in an area of the brain that is not the focus of the epileptic seizures, but is directly connected to it through a network of neurons. If we get the same result in further, long-term studies, it could pave the way for treatment of severe epilepsy", says Mérab Kokaia, professor and director of the Epilepsy Centre at Lund University.

In the study, published in the research journal Scientific Reports, researchers succeeded in reducing epileptic activity in the hippocampus, an area of the brain which is important for memory and learning, among other things. In the most severe cases, this is exactly the part of the brain where epileptic seizures usually start.

The researchers used a method known as chemogenetics, which enables them to reduce activity in the specific areas and nerve cells involved in an epileptic seizure, whereas other parts and cells in the body remain unaffected. This is in contrast to current drugs that affect more or less all parts and cells of the body, potentially leading to side-effects.

"Very few similar studies have been carried out previously, and this is the first study in which we succeeded in reducing the epileptic activity in one area of the brain by using chemogenetics to affect another area, not the seizure focus. This opens up the possibility of treating epilepsy in areas of the brain that cannot be surgically removed or treated directly", explains Mérab Kokaia.

In Sweden, around 60 000 people currently suffer from epilepsy, of whom around a third have such a severe form of the disease that current treatment with existing drugs does not work.

"We hope that, in the future, this knowledge will help people with this severe form of epilepsy, but also that it will benefit other patients with the disease", concludes Mérab Kokaia.
-end-


Lund University

Related Epilepsy Articles from Brightsurf:

Focal epilepsy often overlooked
Having subtler symptoms, a form of epilepsy that affects only one part of the brain often goes undiagnosed long enough to cause unexpected seizures that contribute to car crashes, a new study finds.

Antibodies in the brain trigger epilepsy
Certain forms of epilepsy are accompanied by inflammation of important brain regions.

Breaching the brain's defense causes epilepsy
Epileptic seizures can happen to anyone. But how do they occur and what initiates such a rapid response?

Using connectomics to understand epilepsy
Abnormalities in structural brain networks and how brain regions communicate may underlie a variety of disorders, including epilepsy, which is one focus of a two-part Special Issue on the Brain Connectome in Brain Connectivity, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

Epilepsy: Triangular relationship in the brain
When an epileptic seizure occurs in the brain, the nerve cells lose their usual pattern and fire in a very fast rhythm.

How concussions may lead to epilepsy
Researchers have identified a cellular response to repeated concussions that may contribute to seizures in mice like those observed following traumatic brain injury in humans.

Understanding epilepsy in pediatric tumors
A KAIST research team led by Professor Jeong Ho Lee of the Graduate School of Medical Science and Engineering has recently identified a neuronal BRAF somatic mutation that causes intrinsic epileptogenicity in pediatric brain tumors.

Can medical marijuana help treat intractable epilepsy?
A new British Journal of Clinical Pharmacology review examines the potential of medicinal cannabis -- or medical marijuana -- for helping patients with intractable epilepsy, in which seizures fail to come under control with standard anticonvulsant treatment.

Fertility rates no different for women with epilepsy
'Myth-busting' study among women with no history of infertility finds that those with epilepsy are just as likely to become pregnant as those without.

Do women with epilepsy have similar likelihood of pregnancy?
Women with epilepsy without a history of infertility or related disorders who wanted to become pregnant were about as likely as their peers without epilepsy to become pregnant.

Read More: Epilepsy News and Epilepsy Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.