Nav: Home

When prostate cancer reaches bone, bone cells may drive overall growth of the disease

April 16, 2018

When prostate cancer metastasizes to bone, it can become especially dangerous - not only with its action in the bone but, interestingly, with increased aggressiveness of the overall cancer itself. Now, research presented at the American Association for Cancer Research (AACR) Annual Meeting 2018 hints at why: Cells involved in these bone metastases may release signals that drive the progression of the disease.

"With prostate cancer, often a patient will come in with new bone growth, which can be really painful. What we show is that some of the same things that cause this new bone growth may help the cancer grow and spread," says Philip Owens, PhD, investigator at the University of Colorado Cancer Center and Denver Veterans Administration Hospital Research Program.

Specifically, Owens looked at growth factors called bone morphogenetic proteins (BMPs). As the name implies, BMPs aid the growth of healthy bone - and are even used to grow new bone in procedures like spinal fusion. But mutations that dysregulate BMP - both turning up or turning down its activity - have been implicated in many cancer types. For example, low BMP signaling seems to drive some colorectal cancers, while high BMP signaling is associated with esophageal cancer.

Owens explored BMP signaling in a special kind of cell found in bone and bone marrow known as myeloid cells. These cells are multipotent, able to differentiate into new cell types that form components of bone and blood, especially cell types of the immune system. The current study knocked out the gene BMPR1a, one of these BMPs, specifically in myeloid cells. Mouse models of prostate cancer in which BMPR1a was removed formed fewer, smaller tumors than mice with active BMPR1a. Specifically, it seemed that conditional deletion of BMPR1a removed some of these myeloid cells' stem-like abilities, restricting the kinds of cells they could produce (and in turn, restricting the ability of myeloid cells to drive cancer).

The team had previously shown that the experimental BMP inhibitor, DMH1, had dampened the growth of cancer cells and Owens calls the current study "genetic proof" showing not only that the drug happens to work, but also showing how the drug likely works in cells that are not the tumor themselves.

"We think there's evidence that in many tissues, the BMP that is driving cancer is in fact coming from these myeloid cells. This is an emerging body of evidence showing the anti-cancer benefit of inhibiting BMP signaling in myeloid cells," Owens says.

Owens' continuing work at CU Cancer Center, CU School of Medicine and Denver VA Hospital hopes to continue making the case for BMP inhibition in myeloid cells as a component of prostate cancer treatment, possibly leading to a human trial of this strategy with DMH1 or another BMP inhibitor for patients with metastatic disease.
-end-


University of Colorado Anschutz Medical Campus

Related Prostate Cancer Articles:

ASCO and Cancer Care Ontario update guideline on radiation therapy for prostate cancer
The American Society of Clinical Oncology (ASCO) and Cancer Care Ontario today issued a joint clinical practice guideline update on brachytherapy (internal radiation) for patients with prostate cancer.
Patient prostate tissue used to create unique model of prostate cancer biology
For the first time, researchers have been able to grow, in a lab, both normal and primary cancerous prostate cells from a patient, and then implant a million of the cancer cells into a mouse to track how the tumor progresses.
Moffitt Cancer Center awarded $3.2 million grant to study bone metastasis in prostate cancer
Moffitt researchers David Basanta, Ph.D., and Conor Lynch, Ph.D., have been awarded a U01 grant to investigate prostate cancer metastasis.
New findings concerning hereditary prostate cancer
For the first time ever, researchers have differentiated the risks of developing indolent or aggressive prostate cancer in men with a family history of the disease.
Prostate cancer discovery may make it easier to kill cancer cells
A newly discovered connection between two common prostate cancer treatments may soon make prostate cancer cells easier to destroy.
New test for prostate cancer significantly improves prostate cancer screening
A study from Karolinska Institutet in Sweden shows that a new test for prostate cancer is better at detecting aggressive cancer than PSA.
The dilemma of screening for prostate cancer
Primary care providers are put in a difficult position when screening their male patients for prostate cancer -- some guidelines suggest that testing the general population lacks evidence whereas others state that it is appropriate in certain patients.
Risk factors for prostate cancer
New research suggests that age, race and family history are the biggest risk factors for a man to develop prostate cancer, although high blood pressure, high cholesterol, vitamin D deficiency, inflammation of prostate, and vasectomy also add to the risk.
Prostate cancer is 5 different diseases
Cancer Research UK scientists have for the first time identified that there are five distinct types of prostate cancer and found a way to distinguish between them, according to a landmark study published today in EBioMedicine.
UH Seidman Cancer Center performs first-ever prostate cancer treatment
The radiation oncology team at UH Seidman Cancer Center in Cleveland performed the first-ever prostate cancer treatment April 3 using a newly-approved device -- SpaceOAR which enhances the efficacy of radiation treatment by protecting organs surrounding the prostate.

Related Prostate Cancer Reading:

Prostate Cancer Breakthroughs: The New Options You Need to Know About
by Jay S. Cohen (Author)

"Vital new information for men diagnosed with prostate cancer!"

―George Johnson, Director of the Informed Prostate Cancer Support Group in San Diego, the largest independent group in California

If you or someone you know is one of the thousands of men diagnosed with prostate cancer each year, this book is must reading. In Prostate Cancer Breakthroughs, best-selling author Dr. Jay Cohen provides new information on PSA testing, targeted biopsy, and groundbreaking prostate cancer treatments.

Concise and easy to understand,... View Details


Dr. Patrick Walsh's Guide to Surviving Prostate Cancer
by Patrick C. Walsh (Author), Janet Farrar Worthington (Author)

Each year, more than 230,000 men are diagnosed with prostate cancer, and 30 to 40 percent of patients who are diagnosed will eventually relapse. But the good news is that more men are being cured of this disease than ever before. Now in a revised third edition, this lifesaving guide by Dr. Patrick Walsh and award-winning science writer Janet Farrar Worthington offers a message of hope to every man facing this illness. Prostate cancer is a different disease in every man, which means that the right treatment varies for each man. Readers will discover their risk factors, simple changes that can... View Details


Prostate Cancer: A New Approach to Treatment and Healing
by Dr. Emilia A. Ripoll (Author), Mark B. Saunders (Author)

Prostate Cancer: A New Approach to Treatment and Healing gives readers new access to leading-edge medical information about prostate cancer, by making it simple and easy-to-understand. Essentially, this is a picture book for adults, written in everyday English, with lots of state-of-the-art information to support all the images, flow charts, tables, and diagrams. Each chapter has a patient story, doctor story, and interactive Toolbox section. The book also contains a Spouses Section (because no one goes through a prostate cancer diagnosis alone) and a Digging Deeper section for readers... View Details


You Can Beat Prostate Cancer: And You Don't Need Surgery to Do It
by Robert J. Marckini (Author)

The task of choosing the right prostate cancer treatment is daunting. It is further complicated by conflicting information the patient receives from physicians and the Internet. This book is written by a prostate cancer survivor who now runs an international prostate cancer support group. It's about his journey and the important things he learned along the way. It is the book the author wishes had been available when he was diagnosed 6 years ago. It is intended to provide specific information for men who are at risk or have been recently diagnosed with prostate cancer. All major treatment... View Details


The Key to Prostate Cancer: 30 Experts Explain 15 Stages of Prostate Cancer
by Dr Mark Scholz (Author)

This book directs patients to understand options and educate them about treatments specific for their stage of prostate cancer.
 
·A short STAGING QUIZ directs patients to their correct stage and which of the seven sections of the book to read.
 
·The book is divided into seven sections written by experts in prostate cancer. Five of the sections cover the FIVE STAGES OF BLUE.
 
·The average reader will only need to read three sections: Section I, which covers PSA,Gleason score and body scans, Section VII, which covers lifestyle and general health and... View Details


Prostate and Cancer: A Family Guide to Diagnosis, Treatment, and Survival
by Sheldon Marks (Author)

Prostate cancer is one of the most common cancers affecting American men, with over 186,000 new cases diagnosed in the United States annually; 1 in 6 men will be diagnosed with prostate cancer during his lifetime. Renowned prostate cancer specialist Sheldon Marks offers the definitive guide for men concerned about or diagnosed with prostate cancer, and for their families.

Since the third edition (2003), there have been significant changes in treatment and resources. Working with Dr. Judd Moul, the Chairman of Urology at Duke and one of the world's top experts on prostate cancer, Marks... View Details


Thrive Don't Only Survive: Dr.Geo's Guide to Living Your Best Life Before & After Prostate Cancer
by Dr. Geo Espinosa (Author)

Prostate cancer is not the end—it’s the beginning. It’s the point where you start taking control.

Information on what to do isn't hard to find. There are dozens of books on prostate cancer, as well as a massive amount of online resources. What's lacking, however, is a trusted, reliable source on implementing the abundance of scientific evidence in a way that’s realistic and sustainable.

Based on his extensive research and clinical experience on natural medicine for prostate problems, Dr. Geo has created a lifestyle blueprint that men can apply immediately to thrive before or... View Details


100 Questions & Answers About Prostate Cancer
by Pamela Ellsworth (Author)

100 Questions & Answers About Prostate Cancer provides authoritative and practical answers to the most common questions asked by patients and their loved ones. Providing both doctor and patient perspectives, this easy-to-read book is a comprehensive guide to the basics of prostate cancer, risk factors and prevention, diagnosis, treatment, survivorship, and life after diagnosis. Written by Dr. Pamela Ellsworth, a prominent urologist and best-selling author, Questions & Answers About Prostate Cancer is an invaluable resource for anyone interested in learning what to expect after being diagnosed... View Details


The Decision: Your prostate biopsy shows cancer. Now what?: Medical insight, personal stories, and humor by a urologist who has been where you are now.
by John C. McHugh M.D. (Author), Johanna C. Craig Ph.D. (Editor), Graham L. Gaines (Editor), William P. Black (Editor), Travis Massey (Editor), Sandra B. Brim Ph.D. (Editor), Janice K. Watts (Editor)

Over 200,000 times a year in the U.S. a patient will leave his urologist's office having been told he has prostate cancer. What the patient thought to be a disease of old men from which they do not die, now becomes a very complicated and frustrating dilemma about which treatment to pursue. "The Decision" offers the reader an insider's view to the key issues necessary for a well thought-out treatment plan peculiar only to him. Being a urologist who treats prostate cancer and having had the disease as well, uniquely positions the author in offering guidance to the newly diagnosed prostate... View Details


Dr. Peter Scardino's Prostate Book, Revised Edition: The Complete Guide to Overcoming Prostate Cancer, Prostatitis, and BPH
by Peter T. Scardino M.D. (Author), Judith Kelman (Author)

Newly revised, with up-to-the-minute findings: the potentially lifesaving guide to prostate health by one of the world's foremost urologists

Although most men know little about their prostate glands, an overwhelming majority will be affected by prostate problems at some time in their lives. In this groundbreaking book, now updated to include the latest medical break-throughs, world-renowned urology expert Dr.Peter Scardino arms men with the information they need to battle prostate cancer, prostatitis, and benign prostate enlargement (BPH). This updated edition includes new... View Details

Best Science Podcasts 2018

We have hand picked the best science podcasts for 2018. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Turning Kids Into Grown-Ups
Parenting is fraught with uncertainty, changing with each generation. This hour, TED speakers share ideas about raising kids and how — despite our best efforts — we're probably still doing it wrong. Guests include former Stanford dean Julie Lythcott-Haims, former firefighter Caroline Paul, author Peggy Orenstein, psychologist Dr. Aala El-Khani, and poet Sarah Kay.
Now Playing: Science for the People

#470 Information Spookyhighway
This week we take a closer look at a few of the downsides of the modern internet, and some of the security and privacy challenges that are becoming increasingly troublesome. Rachelle Saunders speaks with cyber security expert James Lyne about how modern hacking differs from the hacks of old, and how an internet without national boards makes it tricky to police online crime across jurisdictions. And Bethany Brookshire speaks with David Garcia, a computer scientist at the Complexity Science Hub and the Medical University of Vienna, about the recent Cambridge Analytica scandal, and how social media platforms put a wrench...