Brain wiring differences identified in children with conduct disorder

April 18, 2019

Behavioural problems in young people with severe antisocial behaviour - known as conduct disorder - could be caused by differences in the brain's wiring that link the brain's emotional centres together, according to new research led by the University of Birmingham.

Conduct disorder affects around 1 in 20 children and teenagers and is one of the most common reasons for referral to child and adolescent mental health services. It is characterised by a wide range of antisocial or aggressive behaviours such as vandalism, weapon use and harm to others. It is often also associated with other disorders such as attention-deficit/hyperactivity disorder (ADHD), anxiety, or depression.

The exact causes of conduct disorder - thought to be an interaction between genetic and environmental factors - are not well understood, but scientists in the University's Centre for Human Brain Health and the Institute for Mental Health have found that there are distinctive differences in white matter pathways (the brain's structural wiring) among young people who have the condition.

The researchers investigated differences in the brain's structure between children with conduct disorder and a comparison group of typically-developing children without severe antisocial behaviour. The study included nearly 300 children aged between 9 and 18, with equal numbers of boys and girls.

Each volunteer underwent a brain scan using a magnetic resonance imaging (MRI) scanning technique called diffusion-tensor imaging to examine differences in white matter fibre tracts - which carry signals between different areas of the brain.

One of the largest differences identified by the team was in an area of the brain called the corpus callosum, the largest white matter fibre tract in the brain and a major pathway which connects the two hemispheres of the brain together. The MRI results suggested there was less branching along these fibres, so the connections between the left and right sides of the brain were less efficient in young people with conduct disorder as compared to the comparison group. Interestingly, the researchers found that boys and girls with conduct disorder showed the same structural abnormalities within this pathway in the brain.

The researchers also investigated whether certain antisocial behaviours, such as aggression, or personality traits, such as reduced empathy or guilt, were linked to the observed changes in brain structure. They found that the differences in the corpus callosum were linked to callous behaviour, including deficits in empathy and a disregard for other people's feelings.

Increasing our understanding of how the brain is wired differently in young people with conduct disorder is an important area of research because it may help clinicians to diagnose the condition more accurately and guide the development of effective interventions in the future.

"The differences that we see in the brains of young people with conduct disorder are unique in so much as they are different from the white matter changes that have been reported in other childhood conditions such as autism or ADHD," says Dr Jack Rogers, co-lead author on the study.

"Additionally we found that callous traits, such as reduced empathy and guilt, explained some of the white matter differences seen in youths with conduct disorder suggesting that these traits are important factors to consider when exploring differences in the brains of young people with conduct disorder".

Dr Stephane De Brito, also co-lead author, adds: "It can be really difficult to get a diagnosis for children with conduct disorder - partly because it is often obscured by other conditions, but also because it is frequently not seen as a genuine disorder. Increasing our understanding of what these structural differences look like in the brain might lead to more accurate diagnosis in the future, but also will help us develop and test interventions that can help children at a critical period of brain development."

Dr Graeme Fairchild, a Reader in the Department of Psychology at the University of Bath and a collaborator on the project, said: "This is the first large-scale study looking at white-matter pathways in the brains of girls and boys with conduct disorder. The results demonstrate that there are reliable differences in the connectivity of these pathways, and that these differ from those seen in other mental health conditions such as depression. It will be important to study whether these white matter changes cause conduct disorder by studying how the brain develops over time, and also whether these brain changes can be modified by psychological interventions."
-end-
The study is part of a much wider, EU-funded consortium project called FemNAT-C, coordinated by Professor Dr. Christine M. Freitag, Frankfurt, Germany) which is investigating similarities and differences between boys and girls with conduct disorder. The project involves 13 Universities and clinics across Europe and looks not just at the brain, but also genetics, hormone levels, emotion recognition and regulation, and physiological activity.

For further information please contact Beck Lockwood, Press Office, University of Birmingham, tel 0121 414 2772: email: r.lockwood@bham.ac.uk

Notes to editor:

* The University of Birmingham is ranked amongst the world's top 100 institutions. Its work brings people from across the world to Birmingham, including researchers, teachers and more than 6,500 international students from over 150 countries.

* Rogers JC, Gonzalez-Madruga K, Kohls G, Baker RH, Clanton RL, Pauli R, Birch P, Chowdhury AI, Kirchner M, Andersson JLR, Smaragdi A, Puzzo I, Baumann S, Raschle NM, Fehlbaum LV, Menks WM, Steppan M, Stadler C, Konrad K, Freitag CM, Fairchild G, De Brito SA, White Matter Microstructure in Youths With Conduct Disorder: Effects of Sex and Variation in Callous Traits, Journal of the American Academy of Child & Adolescent Psychiatry (2019), doi: https://doi.org/10.1016/ j.jaac.2019.02.019.

University of Birmingham

Related Mental Health Articles from Brightsurf:

Mental health strained by disaster
A new study found that suicide rates increase during all types of disasters -- including severe storms, floods, hurricanes and ice storms -- with the largest overall increase occurring two years after a disaster.

The mental health impact of pandemics for front line health care staff
New research shows the impact that pandemics have on the mental health of front-line health care staff.

World Mental Health Day -- CACTUS releases report of largest researcher mental health survey
On the occasion of 'World Mental Health Day' 2020, CACTUS, a global scientific communications company, has released a global survey on mental health, wellbeing and fulfilment in academia.

Mental illness, mental health care use among police officers
A survey study of Texas police officers examines how common mental illness and mental health care use are in a large urban department.

COVID-19 outbreak and mental health
The use of online platforms to guide effective consumption of information, facilitate social support and continue mental health care delivery during the COVID-19 pandemic is discussed in this Viewpoint.

COVID-19 may have consequences for mental health
The COVID-19 pandemic appears to be adversely affecting mental health among hospitalised patients, the healthcare professionals treating them and the general population.

Mental health outcomes among health care workers during COVID-19 pandemic in Italy
Symptoms of posttraumatic stress disorder, depression, anxiety and insomnia among health care workers in Italy during the COVID-19 pandemic are reported in this observational study.

Mental ill health 'substantial health concern' among police, finds international study
Mental health issues among police officers are a 'substantial health concern,' with around 1 in 4 potentially drinking at hazardous levels and around 1 in 7 meeting the criteria for post traumatic stress disorder and depression, finds a pooled data analysis of the available international evidence, published online in Occupational & Environmental Medicine.

Examining health insurance nondiscrimination policies with mental health among gender minority individuals
A large private health insurance database was used to examine the association between between health insurance nondiscrimination policies and mental health outcomes for gender minority individuals.

Mental health care for adolescents
Researchers examined changes over time in the kinds of mental health problems for which adolescents in the United States received care and where they got that care in this survey study with findings that should be interpreted within the context of several limitations including self-reported information.

Read More: Mental Health News and Mental Health Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.