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Scientists uncover details on the rise of a tick-borne disease on Long Island

April 20, 2017

Scientists at the Center for Infection and Immunity (CII) at Columbia University's Mailman School of Public Health report elevated levels of a pathogen responsible for the tick-borne disease babesiosis in Suffolk County, New York, where rates are the highest in the state. Results are published in the journal mSphere.

Researchers developed and employed a method to simultaneously test for five common pathogens carried by deer ticks: Babesia microti, the pathogen behind babesiosis; Borrelia burgdorferi, the cause of Lyme disease; as well as Anaplasma phagocytophilum, Borrelia miyamotoi, and Powassan virus -- pathogens responsible for other tick-borne infections.

The team collected and tested 318 adult and nymph ticks at five sites in Suffolk County (Southampton, Mannorville, Southold, Islip, Huntington) and three sites in Connecticut (Mansfield, Stamford, Greenwich). Nymphal ticks are about the size of a poppy seed, emerge in warmer months, and are responsible for the majority of tick-borne disease.

A Better Test

The new test uses a DNA amplification technique called polymerase chain reaction or PCR to test for tick-borne pathogens. Most existing tests use this method to test ticks for each agent individually. Even the tests that have the ability to test for more than one agent typically only test for up to three, not five agents, and never for Powassan virus, the rarest but most pathogenic of the five. The scientists say the technique has several advantages: it lowers costs, facilitates testing for agents (B. miyamotoi, and especially Powassan virus) that are rarely tested for, and provides risk assessments for co-infections which may adversely affect the course of disease.

What They Found

Tests found B. microti present in a higher proportion of ticks in Suffolk County than Connecticut, including 17 vs. 7 percent of nymphal ticks. In both locations, B. burgdorferi, the causative agent for Lyme disease, was the most frequently detected agent in ticks tested while A. phagocytophilum, B. miyamotoi and Powassan virus were more rare.

One-quarter of B. burgdorferi-positive nymphs were also positive for B. microti suggesting a risk of co-infection with both agents from a single tick bite. "Gathering data on co-infections is particularly important in light of the fact that antibiotics used for Lyme disease may be ineffective for babesiosis," says first author Rafal Tokarz, a research scientist at CII.

Better Surveillance Needed

The number of counties in the Northeast with high rates of Lyme disease has more than tripled since the 1990s -- a sign that ticks that spread disease have expanded their range. Rates of tick-borne illness may be much higher than reported: one study in Minnesota found 79 percent of cases were not reported to health authorities. Symptoms include fever and headaches, and, more rarely, neurological complications like encephalitis.

"This new test can strengthen surveillance for tick-borne illnesses which are underreported and growing rapidly," says W. Ian Lipkin director of CII and John Snow Professor of Epidemiology at the Mailman School.
Co-authors including Teresa Tagliafierro and Stephen Sameroff at CII and D. Moses Cucura and Ilia Rochlin at the Suffolk County Department of Public Works. This study was funded through grants from the Steven and Alexandra Cohen Foundation and National Institute of Allergies and Infectious Diseases (U19 AI109761).

Columbia University's Mailman School of Public Health

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