Early screening based on family history may have dramatic effects on colorectal cancer detection

April 20, 2020

In an analysis that included information on adults diagnosed with colorectal cancer between 40 and 49 years of age, almost all patients could have been diagnosed earlier if they had been screened according to current family history-based screening guidelines. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society (ACS).

In many countries, colorectal cancer rates are rising in adults under 50 years of age. To identify those at risk, current guidelines recommend early screening for colorectal cancer among individuals with a family history of the disease. For example, for individuals with a first-degree relative with colorectal cancer, several medical societies recommend initiating screening at 40 years of age or 10 years prior to the age at diagnosis of the youngest relative diagnosed with colorectal cancer.

To estimate the potential impact of family history-based guidelines for screening, Samir Gupta, MD, of the VA San Diego Healthcare System and the University of California San Diego, and his colleagues examined information on individuals 40 to 49 years of age--2,473 with colorectal cancer and 772 without--in the Colon Cancer Family Registry from 1998 to 2007. (The Colon Cancer Family Registry contains information and specimens contributed by more than 15,000 families around the world and across the spectrum of risk for colorectal cancer).

The investigators found that 25 percent of individuals with colorectal cancer and 10 percent of those without cancer met the criteria for family history-based early screening. Almost all (98.4 percent) patients with colorectal cancer who met these criteria should have been screened at a younger age than when their cancer was diagnosed. Therefore, they could have had their cancer diagnosed earlier, or possibly even prevented, if earlier screening had been implemented based on family history-based guidelines.

"Our findings suggest that using family history-based criteria to identify individuals for earlier screening is justified and has promise for helping to identify individuals at risk for young-onset colorectal cancer," said Dr. Gupta. "We have an opportunity to improve early detection and prevention of colorectal cancer under age 50 if patients more consistently collect and share their family history of colorectal cancer, and healthcare providers more consistently elicit and act on family history."
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Full Citation: "Potential impact of family history based screening guidelines on early onset colorectal cancer detection." Samir Gupta, Balambal Bharti, Dennis J. Ahnen, Daniel D. Buchanan, Iona C. Cheng, Michelle Cotterchio, Jane C. Figueiredo, Steven J. Gallinger, Robert W. Haile, Mark A. Jenkins, Noralane M. Lindor, Finlay Macrae, Loïc Le Marchand, Polly A. Newcomb, Stephen N. Thibodeau, Aung Ko Win, and Maria Elena Martinez. CANCER; Published Online: April 20, 2020 (DOI: https://onlinelibrary.wiley.com/doi/10.1002/cncr.32851).

URL Upon Publication: http://onlinelibrary.wiley.com/doi/10.1002/cncr.32851

Author Contact: s1gupta@health.ucsd.edu

About the Journal

CANCER is a peer-reviewed publication of the American Cancer Society integrating scientific information from worldwide sources for all oncologic specialties. The objective of CANCER is to provide an interdisciplinary forum for the exchange of information among oncologic disciplines concerned with the etiology, course, and treatment of human cancer. CANCER is published on behalf of the American Cancer Society by Wiley and can be accessed online.

Follow us on Twitter @JournalCancer

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