Discovery could lead to better asthma treatmentApril 21, 2016
Scientists have made a discovery that could lead to improved treatment for asthma sufferers.
They have found that blocking a certain signalling molecule can alleviate symptoms such as mucus production, swelling (edema), and constriction of the airways in the lungs.
The international study, led by Dr Stephan Caucheteux, from Cardiff University's School of Medicine, believes their work could ultimately help asthma sufferers around the world.
Some 5.4m people in the UK are currently receiving treatment for asthma, including more than a million children.
The allergic immune response, which triggers the symptoms of asthma, is a complex process, which starts with the over-activation of a certain white blood cell, the allergen-specific helper T cells type 2.
"We found that by adding a signaling molecule, Interleukin 1 (IL-1) using an experimental model of allergic asthma, the symptoms would worsen dramatically," explained Dr Caucheteux.
"Therefore by blocking production of IL-1, we could alleviate the symptoms, such as mucus, swelling and constriction."
The research, published in The Journal of Allergy and Clinical Immunology, also involved colleagues at the National Institutes of Health in the USA: Drs Jane Hu-Li, Liying Guo, Michelle Crank, Nisan Bhattacharyya and Michael Collins.
This research project was directed by the late William E Paul, Chief of the Laboratory of Immunology at the National Institute of Allergy and Infectious Diseases.
Dr Jeff Zhu, Chief of the Molecular and Cellular Immunoregulation Unit at the Laboratory of Immunology at the National Institute of Allergy and Infectious Diseases, said: "The finding that IL-1 is involved in regulating the balance between inflammatory and anti-inflammatory Th2 cells has not only significantly enhanced our basic knowledge on T cell biology, but also provided a potentially effective and novel strategy to treat asthma."
Related Asthma Articles:
A team of researchers from the University of Pittsburgh has found that insomnia is highly prevalent in adults with asthma and is also associated with worse asthma control, depression and anxiety symptoms and other quality of life and health issues.
A new study urges caution in the use of the mannitol challenge test for asthma in non-clinical settings.
Working with human immune cells in the laboratory, Johns Hopkins researchers report they have identified a critical cellular 'off' switch for the inflammatory immune response that contributes to lung-constricting asthma attacks.
Kids need flu shots to prevent asthma flares, and medications available in school to keep 86 percent in class, according to two studies being presented at the American College of Allergy, Asthma and Immunology Annual Scientific Meeting.
Scientists have made a discovery that could lead to improved treatment for asthma sufferers.
Defining a patient's symptoms using the historical diagnostic labels of asthma and chronic obstructive pulmonary disease (COPD) is an outdated approach to understanding an individual's condition, according to experts writing in the European Respiratory Journal today.
New research indicates that asthma in many adolescents is not likely to involve inflammation of the airways and therefore should not be considered an allergic disease.
Severe asthma can have a devastating effect on sufferers, affecting their ability to work or go to school and to lead normal lives.
Researchers may be closer to finding the mechanism responsible for loss of lung elastic recoil and airflow limitation in nonsmokers with chronic asthma.
New study in Annals of Allergy, Asthma and Immunology shows how an app directly connecting an allergist and an asthma sufferer can provide necessary intervention when asthma isn't under control.
Related Asthma Reading:
A Cure for Asthma?: What Your Doctor Isn't Telling You--and Why by David L. Hahn MD MS (2013) Paperback
by David L. Hahn MD MS (Author)
This book challenges conventional wisdom about the causes and treatments of asthma. Could hard-to-treat asthma be triggered by a persistent infection? Dr. David Hahn presents the scientific evidence and compelling case histories that led him to his surprising conclusion. He describes the treatment protocol he has used successfully. Find out if your asthma might be cured once and for all instead of managed. View Details
The Allergy and Asthma Cure: A Complete 8-Step Nutritional Program
by Fred Pescatore M.D. (Author)
Free yourself of allergies and asthma once and for all with Dr. Pescatore's breakthrough program
"" Dr. Fred Pescatore's The Allergy and Asthma Cure reveals a unique and revolutionary understanding of the underlying conditions of allergy and asthma-from food triggers to the environment to nutritional deficiencies. His integrative program of both alternative and traditional treatments can dramatically improve health and vitality, safely and soundly. This book will have a prominent place in my library and I highly recommend it! ""
-Ann Louise Gittleman, Ph.D., C.N.S., author of the... View Details
Breathe to Heal: Break Free From Asthma (Learn Buteyko) (Breathing Normalization)
by Sasha Yakovleva (Author), K.P. Buteyko MD-PhD (Author), A.E. Novozhilov MD (Author), Victor Lunn-Rockliffe (Illustrator), Arash Akhgari (Illustrator), Jane E. Brody (Illustrator), Thomas Fredricksen (Illustrator), Ira J. Packman (Illustrator), Jean Boles (Illustrator)
Understand Asthma & Breathing Problems. Stop fighting against asthma attacks and breathing difficulties! Say "Goodbye" to breathing problems! This book will help asthma sufferers to establish natural and wholesome breathing patterns and prevent asthma attacks. It will provide you with the information you need to tame your or your child's breathing difficulties naturally by improving the function of the respiratory system. It contains comprehensive instructions on the Breathing Normalization method based on the discovery by Dr. Buteyko in 1952 in Russia. Since then, this commonly called... View Details
Healing the New Childhood Epidemics: Autism, ADHD, Asthma, and Allergies: The Groundbreaking Program for the 4-A Disorders
by Kenneth Bock (Author), Cameron Stauth (Author)
Autism is an epidemic: It has spiked 1,500 percent in the last twenty years. ADHD, asthma and allergies have also skyrocketed over the same time period. One of these conditions now strikes one in every three children in America. But there is hope. Leading medical innovator Kenneth Bock, M.D., has helped change the lives of more than a thousand children, and in this important book, with a comprehensive program that targets all four of the 4-A disorders, he offers help to children everywhere. This is the book that finally puts hope within reach.
Doctors have generally overlooked the... View Details
Reversing Asthma: Breathe Easier with This Revolutionary New Program
by Richard N. Firshein (Author)
Comprehensive, balanced and up-to-the minute, Reversing Asthma is destined to be the new bible for asthma treatment - giving asthma sufferers new knowledge and new choices for overcoming this frightening and debilitating disease. View Details
Asthma For Dummies
by William E. Berger (Author), Jackie Joyner-Kersee (Foreword)
The incidence of asthma is rising dramatically in the United States and across the globe. Asthma affects 17 million people in the U.S. and is the most common chronic childhood disease. If you or someone you love suffers from asthma, you know that there is no cure—however, with proper care, asthmatics can lead normal, active, and fulfilling lives. Now you can breathe easy with this plain-English guide, which clearly explains the prevention, diagnosis, symptoms, and treatment of the disease.
Asthma For Dummies will help asthma sufferers and their loved ones get a strong handle on... View Details
ASTHMA: A Fresh Approach To Dealing With Asthma
by Ronnie Smith (Author)
What Everyone Needs To Know About This Fresh Approach To Dealing With Asthma... The most brilliant minds in the fields of health, medicine and psychology have tried and failed to find the solution to Asthma. Now, a new approach based on going back to nature rather than man-made medicine is gaining ground throughout the world. This "fresh approach" was initially laughed at and thought to be a joke. But when people started to have incredible results with it the laughter stopped. Now more and more research is gradually being done on this new nutritional approach to dealing with this... View Details
Allergy and Asthma: Practical Diagnosis and Management (LANGE Clinical Medicine)
by Massoud Mahmoudi (Author)
Clear, authoritative guidance for your day-to-day allergy and asthma practice
Allergy and Asthma: Practical Diagnosis and Management is a concise guide that puts the most salient insights in allergy medicine right at your fingertips. Written by a leading allergy clinician, along with more than 40 nationally recognized expert contributors, this resource is perfect for front-line general practitioners, especially primary care physicians and allied health care providers. Inside, you'll find the most clinically relevant information on the pathophysiology, diagnosis,... View Details
Asthma: Relax, You're Not Going to Die: Breathe More Easily with Safe and Effective Natural Therapies
by Jonathan M. Berkowitz (Author)
The natural approach presented in this handbook seeks to help sufferers of asthma to breathe more easily. While drugs have proved lifesaving for many people, the long-term answer for asthma sufferers is in learning how to embrace a healthy lifestyle. Jonathan Berkowitz shows how dietary changes, exercise, environmental controls, supplements and herbs can alleviate your symptoms safely and effectively, without the side effects of conventional drugs. Berkowitz is an asthmatic as well as a physician. View Details
Asthma: How To Get Asthma Free Naturally (asthma cure, asthma free naturally, asthma educator study guide, wheezing, asthma treatment, asthma attacks, hayfever)
by Vicki Joy (Author)
Do you suffer with asthma attacks? Are you looking for asthma treatment that can help you get asthma free naturally? Have you wondered if there is an asthma cure? This book is about natural remedies that can provide relief for asthma symptoms, and reduce the frequency and severity of asthma attacks. In this book you will learn about: What Is Asthma? What Causes An Asthma Attack? Asthma and Diet Natural Remedies for Asthma Over 20 million реорlе in thе United States can't tаkе brеаthing fоr granted because thеу аrе suffering from a chronic rеѕрirаtоrу аilmеnt саllеd... View Details