Nav: Home

Murine models of arrhythmogenic cardiomyopathy benefit from GSK3β inhibition

April 21, 2016

Arrhythmogenic cardiomyopathy (ACM) is an inherited heart disease that results from mutations in genes that encode components of the cardiac desmosome, which forms the junction between cardiac muscle and the epithelium. Patients with ACM have an increased risk of sudden death due to the breakdown of the muscle wall of the heart with age. A previous chemical screen in a zebrafish ACM model identified a glycogen synthase kinase 3β (GSK3β) inhibitor (SB2) that reversed disease. In this issue of JCI Insight, investigators led by Jeffrey Saffitz of Harvard Medical School and Daniel Judge of John's Hopkins School of Medicine examined the effects of the GSK3β inhibitor SB2 in two murine models of ACM. SB2 improved cardiac function, reduced fibrosis and inflammation, and improved survival in both ACM models. In cardiac cells from healthy mice, GSK3β was in the cytosol. However, GSK3β localized to intercellular junctions in mice with ACM. The same GSK3β distribution patterns were also present in cardiac cells from healthy individual and patients with ACM. The results of this study provide further evidence that GSK3β inhibition has potential as a therapeutic strategy for treating ACM.
-end-
TITLE: Central role for GSK3β in the pathogenesis of arrhythmogenic cardiomyopathy

AUTHOR CONTACT: Daniel P. Judge
Johns Hopkins University School of Medicine
Email: djudge@jhmi.edu

Jeffrey E. Saffitz
Harvard Medical School
E-mail: jsaffitz@bidmc.harvard.edu.

View this article at:http://insight.jci.org/articles/view/85923

JCI Insight is the newest publication from the American Society of Clinical Investigation, a nonprofit honor organization of physician-scientists. JCI Insight is dedicated to publishing a range of translational biomedical research with an emphasis on rigorous experimental methods and data reporting. All articles published in JCI Insight are freely available at the time of publication. For more information about JCI Insight and all of the latest articles go to http://www.insight.jci.org.

JCI Journals

Related Genes Articles:

Insomnia genes found
An international team of researchers has found, for the first time, seven risk genes for insomnia.
Genes affecting our communication skills relate to genes for psychiatric disorder
By screening thousands of individuals, an international team led by researchers of the Max Planck Institute for Psycholinguistics, the University of Bristol, the Broad Institute and the iPSYCH consortium has provided new insights into the relationship between genes that confer risk for autism or schizophrenia and genes that influence our ability to communicate during the course of development.
The fate of Neanderthal genes
The Neanderthals disappeared about 30,000 years ago, but little pieces of them live on in the form of DNA sequences scattered through the modern human genome.
Face shape is in the genes
Many of the characteristics that make up a person's face, such as nose size and face width, stem from specific genetic variations, reports John Shaffer of the University of Pittsburgh in Pennsylvania, and colleagues, in a study published on Aug.
Study finds hundreds of genes and genetic codes that regulate genes tied to alcoholism
Using rats carefully bred to either drink large amounts of alcohol or to spurn it, researchers at Indiana and Purdue universities have identified hundreds of genes that appear to play a role in increasing the desire to drink alcohol.
Reading between the genes
For a long time dismissed as 'junk DNA,' we now know that also the regions between the genes fulfill vital functions.
The silence of the genes
Research led by Dr. Keiji Tanimoto from the University of Tsukuba, Japan, has brought us closer to understanding the mechanisms underlying the phenomenon of genomic imprinting.
Why some genes are highly expressed
The DNA in our cells is folded into millions of small packets, like beads on a string, allowing our two-meter linear DNA genomes to fit into a nucleus of only about 0.01 mm in diameter.
Activating genes on demand
A new approach developed by Harvard geneticist George Church, Ph.D., can help uncover how tandem gene circuits dictate life processes, such as the healthy development of tissue or the triggering of a particular disease, and can also be used for directing precision stem cell differentiation for regenerative medicine and growing organ transplants.
Controlling genes with light
Researchers at Duke University have demonstrated a new way to activate genes with light, allowing precisely controlled and targeted genetic studies and applications.

Related Genes Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Bias And Perception
How does bias distort our thinking, our listening, our beliefs... and even our search results? How can we fight it? This hour, TED speakers explore ideas about the unconscious biases that shape us. Guests include writer and broadcaster Yassmin Abdel-Magied, climatologist J. Marshall Shepherd, journalist Andreas Ekström, and experimental psychologist Tony Salvador.
Now Playing: Science for the People

#513 Dinosaur Tails
This week: dinosaurs! We're discussing dinosaur tails, bipedalism, paleontology public outreach, dinosaur MOOCs, and other neat dinosaur related things with Dr. Scott Persons from the University of Alberta, who is also the author of the book "Dinosaurs of the Alberta Badlands".