Florida Or Bust? Older Lab Rats Seek Heat To Fight Infection, UD Researchers Report

April 21, 1998

SAN FRANCISCO, CA.--Geriatric rats instinctively ward off sickness by huddling in hot spots, and ongoing studies of their behavior may suggest drug-free strategies to help older people fight infections, University of Delaware researchers reported today at the Experimental Biology '98 meeting.

"Most older rats, like many older people, either don't get fevers or get low fevers when they have an infection," explains Evelyn Satinoff, chairperson of UD's Department of Psychology and one of the nation's leading researchers in thermoregulation. "While an extremely high fever may be life-threatening, especially for very young children, moderate fever is widely believed to be an essential tool in the immune system's arsenal. In most cases, fever helps the body combat dangerous pathogens."

Compared to young rats, older rats housed at room temperature typically get much lower fevers, but new UD data shows "they can get a fever when they're allowed to select the temperature of their environment," reports Maria Florez-Duquet, a post-doctoral neuroscientist at UD who authored the Experimental Biology paper, along with Research Associate Elizabeth D. Peloso and Satinoff.

If the UD research pans out, Satinoff says, it may ultimately help doctors more easily fight infections among older patients. Although Satinoff emphasizes that the UD work is still preliminary, helping to combat infections "might be as simple as placing an older patient in a very warm room to induce fever," she says.

Heat-Seeking Rodents

Laboratory rats reach the end of their lives around 30 months of age, Florez-Duquet notes. By 24 to 26 months of age, older rats in Satinoff's experiments demonstrate a strong preference for heated areas. "If you're a lab rat with an infection," she says, "selecting a warm environment clearly is a smart thing to do."

To learn more about the drive to survive in older rats, the UD research team initially injected lipopolysaccharide (LPS), a fever-inducting component of bacteria, into a half-dozen animals aged 3-4 months, as well as an equal number of older specimens. When young rats were housed in a room-temperature environment (73.4 degrees Fahrenheit, or 23 degrees Celsius), they all developed fevers, but the condition was rarely apparent among the older animals, according to Peloso, who co-authored early UD findings with former post-doctoral researcher, Maciek Wachulec and Satinoff. (Wachulec et al, "Individual differences in response to LPS and psychological stress in aged rats," American Journal of Physiology, Vol. 272, No. 41, R1252 - R1257, 1997.)

Satinoff suspected, however, that the older rats could develop fever if they were provided with greater control over their environment. So, UD researchers placed tiny transmitters in the abdomens of young and old rats, then recorded and analyzed their behavioral responses to LPS injections. Each animal was placed in a long, box-like alleyway that was cooled at one end and heated at the other end to provide a range of temperature choices, from 50-104 degrees F (10-40 degrees Celsius). The transmitter automatically measured each rat's body temperature every five minutes, while sensors located at regular intervals along the length of the alleyway recorded the animal's position every minute. All data was continuously fed into a computer for analysis. With few exceptions, "Young rats go to the relatively warm part of the alleyway, while older rats prefer even warmer positions," where they produce a fever, Florez-Duquet reports.

How much heat is needed to help older rats induce fever? The UD researchers have been trying to pinpoint an optimal fever-producing temperature by placing animals in cages heated to 68, 86 or 89.6 degrees F (20, 30 and 32 degrees C), Satinoff explains. Older rats do not develop a fever at 68 degrees F, but they develop symptoms of "perfectly normal fevers" in the two warmer environments, she says.

"The next step," Florez-Duquet says, "is to understand the physiological mechanisms that give older animals this ability to behaviorally regulate fever." The immune systems of young versus older rats may function differently, Satinoff says. Older rats may, for instance, have higher levels of particular stress hormones such as corticosterone, which inhibits fever. Or, they might have lower levels of interleukins, the immune-response factors that promote fever. An infection triggers the production of these and other chemicals in the brain, Satinoff notes, and complex neurological reactions may be mediated by exposure to heat.

"Our work has thus far been limited to a relatively small number of animals, and the implications for older people are still speculative," Satinoff cautions. But information about fever regulation among older populations may provide new information for doctors, nursing home administrators and elderly people, she says, because fever is "an important component of the immune-system response."

MEETING BACKGROUND: The Experimental Biology '98 meeting brings together more than 10,000 scientists from six of the world's leading scientific societies. This large, interdisciplinary meeting gives scientists an opportunity to share research findings with colleagues from their own disciplines--and also with scientists attacking some of the same problems from the viewpoint of entirely different disciplines. Their focus is on the newest scientific concepts and study results about processes that underlie function, disease and therapy. This year's meeting in San Francisco is sponsored by the American Physiological Society, American Society for Pharmacology and Experimental Therapeutics, American Society for Investigative Pathology, American Society for Nutritional Sciences, American Association of Immunologists, and American Association of Anatomists. Nineteen guest societies also are participating.

PRESENTATION INFORMATION: This news release describes a poster presentation scheduled to take place 1-3 p.m., Tuesday, April 21, 1998, in Room A-360 of the Moscone Convention Center, San Francisco.

Click here to see photographs associated with this release.
-end-


University of Delaware

Related Infection Articles from Brightsurf:

Halving the risk of infection following surgery
New analysis by the University of Leeds and the University of Bern of more than 14,000 operations has found that using alcoholic chlorhexidine gluconate (CHG) halves the risk of infection in certain types of surgery when compared to the more commonly used povidone-iodine (PVI).

How plants shut the door on infection
A new study by an international team including University of Maryland scientists has discovered the key calcium channel responsible for closing plant pores as an immune response to pathogen exposure.

Sensing infection, suppressing regeneration
UIC researchers describe an enzyme that blocks the ability of blood vessel cells to self-heal.

Boost to lung immunity following infection
The strength of the immune system in response to respiratory infections is constantly changing, depending on the history of previous, unrelated infections, according to new research from the Crick.

Is infection after surgery associated with increased long-term risk of infection, death?
Whether experiencing an infection within the first 30 days after surgery is associated with an increased risk of another infection and death within one year was the focus of this observational study that included about 660,000 veterans who underwent major surgery.

Revealed: How E. coli knows how to cause the worst possible infection
The discovery could one day let doctors prevent the infection by allowing E. coli to pass harmlessly through the body.

UK study shows most patients with suspected urinary tract infection and treated with antibiotics actually lack evidence of this infection
New research presented at this week's European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) in Amsterdam, Netherlands (April 13-16, 2019) shows that only one third of patients that enter the emergency department with suspected urinary tract infection (UTI) actually have evidence of this infection, yet almost all are treated with antibiotics, unnecessarily driving the emergence of antimicrobial resistance.

Bacteria in urine doesn't always indicate infection
Doctors should think carefully before testing patients for a urinary tract infection (UTI) to avoid over-diagnosis and unnecessary antibiotic treatment, according to updated asymptomatic bacteriuria (ASB) guidelines released by the Infectious Diseases Society of America (IDSA) and published in Clinical Infectious Diseases.

Subsidies for infection control to healthcare institutions help reduce infection levels
Researchers compared three types of infection control subsidies and found that under a limited budget, a dollar-for-dollar matching subsidy, in which policymakers match hospital spending for infection control measures, was the most effective at reducing the number of hospital-acquired infections.

Dengue virus infection may cause severe outcomes following Zika virus infection during pregnancy
This study is the first to report a possible mechanism for the enhancement of Zika virus progression during pregnancy in an animal model.

Read More: Infection News and Infection Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.