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Is sickle cell trait genetic risk factor for increased stroke risk?

April 23, 2018

BottomLine: Sickle cell trait may not be associated with the occurrence of ischemic stroke (when a blood clot blocks a blood vessel in the brain) in African Americans, according to a meta-analysis that combined the results of four studies with 19,464 African American participants.

Why The Research Is Interesting: African Americans and individuals of African ancestry are at higher risk of stroke than individuals who are non-Hispanic white. Understanding sources of this disparity could help to identify people at risk and help to target therapy. It is unclear if sickle cell trait is a genetic risk factor for increased risk of ischemic stroke among African Americans.

Authors: Hyacinth I. Hyacinth, M.D., Ph.D., of Emory University School of Medicine, Atlanta, and coauthors

Study Design: This was a meta-analysis. A meta-analysis combines the results of multiple studies and quantitatively summarizes the overall association between the same exposure and outcomes measured across all studies.
-end-
To Learn More: The full study is available on the For The Media website.

(doi:10.1001/jamaneurol.2018.0571)

Editor's Note: The article contains funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc. To place an electronic embedded link in your story: Links will be live at the embargo time: http://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2018.0571

JAMA Neurology

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