Experts issue guide on lung cancer screening, management during COVID-19

April 23, 2020

OAK BROOK, Ill. (April 23, 2020) - A new expert panel consensus statement published simultaneously today in the journals Radiology: Imaging Cancer, Chest and the Journal of the American College of Radiology provides guidance to clinicians managing lung cancer screening programs and patients with lung nodules during the COVID-19 pandemic.

In many parts of the world, the COVID-19 public health crisis has stressed the health care system close to or even past its breaking point. Hospital resources are focused on the immediate needs of patients suffering from the disease, particularly those who are critically ill. The strain on health care systems and the need to control the virus using containment and mitigation has impacted the care of patients with other common medical disorders.

Clinicians have been forced to balance the risk of delaying potentially necessary exams against the risk of exposing patients to the virus in hospital settings or exposing health care workers to patients who may be asymptomatic carriers of the disease. This is further complicated by the re-allocation of resources, including hospital personnel, to evaluate and treat patients with COVID-19.

"The potential risk of exposure or transmission during routine care, as well as the diversion of resources to help combat the pandemic, has forced clinicians to make decisions about the timing of care," said Peter J. Mazzone, M.D., M.P.H., FCCP, director of the Lung Cancer Program and Lung Cancer Screening Program for the Cleveland Clinic Respiratory Institute. "This document provides guidance that we hope will help with these decisions. It outlines acceptable variances from standard practice during the pandemic and provides items to consider that could influence the decisions for a given patient."

Performing a lung cancer screening exam or the evaluation of lung nodules both carry additional risk during the COVID-19 pandemic. There is added risk to the patient, other patients and health care providers from exposure to the health care environment and the contact that occurs during testing. Recovery from surgical resection may be influenced by asymptomatic carriage of the virus. These added risks may upset the balance of benefit and harm struck by current (pre-COVID) guideline recommendations. There is also a shift in health care resources, toward canceling elective procedures and imaging, in areas where

COVID-19 is surging, or where systems are preparing for a surge, making it more difficult to adhere to available guidelines. These exposure risks and resource constraints have led the Centers for Disease Control and Prevention (CDC) to suggest that non-urgent care be deferred.

To date, clinicians and hospital systems have been independently determining how to modify their screening and lung nodule management programs during the pandemic. The consensus statement was developed to provide expert opinion to clinicians regarding the performance of lung cancer screening and the management of patients with lung nodules in a manner that is consistent with current CDC COVID-19 guidance.

Three project leaders and 21 panel members participated in developing the consensus statement. Their specialties included pulmonology, thoracic radiology and thoracic surgery. Twelve scenarios were developed, each with a statement requiring a vote. The voting results for all statements exceeded the threshold of 70% of panel members voting agree or strongly agree. Scenarios recommendations and notes are included in the report.

Consensus was unanimous for recommendations to delay baseline or repeat annual screening, and over 95% of panelists agreed to delay the evaluation of pulmonary nodules detected incidentally or by screening that have a low probability of cancer or are likely to be an indolent cancer.

Consensus was less uniform but still strong for recommendations to delay or modify the evaluation and management of patients with nodules measuring greater than 8 millimeters in average diameter.

The authors note that these recommendations are not "one-size-fits-all" and state that patient preferences should be considered in all of the scenarios, because individual patients are likely to differ in how they perceive the potential benefits and harms associated with delayed or modified evaluation and management.

The paper points out that due to the fluidity of the situation, it is not possible at this time to determine when it will be advisable to return to usual care practices.

"We hope these statements are helpful and provide some reassurance and direction to individuals who are eligible for lung cancer screening, patients with lung nodules, and the clinicians who care for them," the authors conclude.

RSNA is committed to connecting radiologists and the radiology community to the most timely and useful COVID-19 information and resources. RSNA's COVID-19 Resources page houses the latest guidance, original research, image collection and more. The page will be updated on an ongoing basis.
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"Management of Lung Nodules and Lung Cancer Screening During the COVID-19 Pandemic: CHEST Expert Panel Report." Peter J. Mazzone, M.D., M.P.H., FCCP, Michael K. Gould, M.D., FCCP, Douglas A. Arenberg, M.D., FCCP, Alexander C. Chen, M.D., Humberto K. Choi, M.D., FCCP, Frank C. Detterbeck, M.D. , FCCP, Farhood Farjah, M.D., M.P.H., Kwun M. Fong, M.D., Jonathan M. Iaccarino, M.D., Samuel M. Janes, Ph.D., Jeffrey P. Kanne, M.D., FCCP, Ella A. Kazerooni, M.D., Heber MacMahon, M.B.B.Ch., David P. Naidich, M.D., FCCP, Charles A. Powell, M.D., FCCP, Suhail Raoof, M.D., Master FCCP, M. Patricia, Rivera, M.D., FCCP, ATSF, Nichole T. Tanner, M.D., M.S.C.R., FCCP, Lynn K. Tanoue, M.D., FCCP, Alain Tremblay, M.D.C.M., Anil Vachani, M.D., M.S., FCCP, Charles S. White, M.D., Renda Soylemez Wiener, M.D., M.P.H., Gerard A. Silvestri, M.D., M.S., FCCP.

Radiology: Imaging Cancer is edited by Gary D. Luker, M.D., Michigan Medicine, University of Michigan, Ann Arbor, and owned and published by the Radiological Society of North America, Inc. (https://pubs.rsna.org/journal/imaging-cancer)

RSNA is an association of radiologists, radiation oncologists, medical physicists and related scientists promoting excellence in patient care and health care delivery through education, research and technologic innovation. The Society is based in Oak Brook, Illinois. (RSNA.org)

The American College of Radiology (ACR) is a membership organization of nearly 40,000 radiologists, radiation oncologists and medical physicists dedicated to serving patients and society by empowering radiology professionals to advance the practice, science and professions of radiological care. (ACR.org)

The American College of Chest Physicians® (CHEST) is the global leader in prevention, diagnosis, and treatment of chest diseases. Its mission is to champion advanced clinical practice, education communication, and research in chest medicine. It serves as an essential connection to clinical knowledge and resources for its 19,000+ members from around the world who provide patient care in pulmonary, critical care, and sleep medicine. For information about the American College of Chest Physicians, and its flagship journal CHEST®, visit chestnet.org

For information on lung cancer screening and chest CT, visit RadiologyInfo.org.

Radiological Society of North America

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