Research shows possible new target for immunotherapy for solid tumorsApril 24, 2018
CINCINNATI--Research from the University of Cincinnati (UC) reveals a potential new target to help T cells (white blood cells) infiltrate certain solid tumors.
This study, being published in the April 24 advance online edition of the journal Science Signaling, showed that by targeting a certain potassium channel--KCa3.1--the CD8+ T cell migration in patient samples was restored, meaning that they could potentially be more effective in moving in on the tumor and attacking it. CD8+ cells are a type of T cell capable of killing cancer cells.
"Reduced potassium channel activity curbs T cell movement within the tumor," says Laura Conforti, PhD, professor in the Department of Internal Medicine at the UC College of Medicine, a researcher within the Cincinnati Cancer Center and UC Cancer Institute and corresponding author on the study. "T cell infiltration in solid tumors is limited by multiple factors found within the tumor's microenvironment, including adenosine, an immunosuppressive substance accumulating in high amounts in solid tumors."
Conforti and her team, led by Ameet Chimote, PhD, a research associate in the Department of Internal Medicine, analyzed the migration of CD8+ T cells in a 3-D experimental model system that allows the reproduction of some features of the tumor microenvironment and found that when adenosine was present, it inhibited the movement of T cells from cancer patients more than T cells from healthy donors.
"The increased sensitivity of patient CD8+ T cells to adenosine correlated with reduced KCa3.1 channel activity, but not with adenosine receptor expression or signaling," she says. "Treatment with a substance that restores the KCa3.1 channel activity corrects patient CD8+ T cell migration in the presence of adenosine, suggesting that potassium channel activators may help enhance T cell infiltration of adenosine-rich solid tumors, providing another therapy option.
"This finding could lead to the development of new therapeutic agents to use in combination with approved immunomodulators for the treatment of solid tumors, as they may improve their efficacy."
University of Cincinnati Academic Health Center
Related Cancer Patients Articles:
Could lung cancer be hiding in kidney cancer patients? Researchers with the Harold C.
Patients who have chronic kidney disease but are not on dialysis have higher out-of-pocket healthcare expenses than even stroke and cancer patients, according to a Loyola University Chicago study published in BMC Nephrology.
A study of advanced cancer patients published in the journal Annals of Oncology and presented at this year's World Congress of Anaesthesiologists in Hong Kong suggests that opioid painkillers and their receptor in cells -- the mu opiate receptor -- could be involved in cancer progression, and could thus be a target for treatments.
University of Colorado Cancer Center study presented at the American Society for Clinical Oncology (ASCO) Annual Meeting 2016 finds that in patients over 50, the rate of CRC is falling at 2.5 percent per year while the rate of CRC in patients under 50 is rising at 0.8 percent per year.
Overweight colorectal cancer patients were 55 percent less likely to die from their cancer than normal-weight patients who have the disease, according to a new Kaiser Permanente study published today in JAMA Oncology.
Researchers have found that treating patients who have early stage non-small cell lung cancer with a type of radiotherapy called stereotactic body radiation therapy is associated with a small but increased risk of death from causes other than cancer.
It is critically important that colorectal cancer patients undergo colonoscopy after surgery to ensure that they do not have a second colon cancer, and to find and remove any additional polyps.
Postponing the start of adjuvant chemotherapy for more than 90 days following surgery may significantly increase risk of death for breast cancer patients, particularly those with triple-negative breast cancer, according to a new study from the University of Texas MD Anderson Cancer Center.
Although being overweight with a high body-mass index has long been associated with a higher risk for colorectal cancer, thinner patients might not fare as well after treatment for advanced cancer, according to a new study from Duke Medicine.
A new analysis has found that, among patients with cancer, rates of health insurance coverage vary by patient demographics and by cancer type.
Related Cancer Patients Reading:
Everyday Strength: A Cancer Patient's Guide to Spiritual Survival
by Randy Becton (Author), Dave Dravecky (Foreword)
As a cancer survivor, Randy Becton knows firsthand the onslaught this disease brings on the human spirit. His experience creates a special bond with fellow cancer patients, making his encouragement even more powerful. In Everyday Strength he offers hope and comfort through poetic prayers, Scripture, brief reflections, and uplifting thoughts for each day.
Everyday Strength deals honestly with topics such as depression, anger, fear, and loneliness. It guides those who are fighting cancer toward spiritual and mental wellness in the face of physical illness. First published in 1989, these... View Details
50 Days of Hope: Daily Inspiration for Your Journey through Cancer
by Lynn Eib (Author)
You’ve just heard a diagnosis that shakes your world: It's cancer. And what you long for most is the hope that everything will be okay. You are not alone. As a longtime cancer survivor, Lynn Eib knows firsthand how that feels. And as a patient advocate helping thousands facing cancer, she also knows what gives people hope. In 50 Days of Hope, Lynn shares amazing, true stories of those who have been in your shoes and discovered that when God and cancer meet, hope is never far away. Whether you’re a cancer patient or walking with a loved one on a cancer journey, you’ll find 50... View Details
E.A.T.: An Unconventional Decade In The Life Of A Cancer Patient
by Kathy Mydlach Bero (Author)
E.A.T. An Unconventional Decade In The Life Of A Cancer Patient was written in journal format, and is based on the 18 journals Kathy kept during her battle with two rare and aggressive cancers. She refused to accept the prognosis of death and found herself tallying the limitations of conventional medical protocol, which led to Kathy's conviction that neither cancer nor doctors would determine her fate. Despite taking advantage of everything her hospital had offered, Kathy's body was failing, leaving her to live half dead. Her story is an intimate portrait, chronicling the frustrations and... View Details
Natural Strategies For Cancer Patients
by Russell Blaylock M.D. (Author)
Cancer and current cancer treatments wage war on the body, but Russell L. Blaylock - a respected doctor and clinical assistant professor of neurosurgery - has developed an easy-to-follow program to fight back naturally. This book shows how easy it can be to fortify nutritional status during this critical time. View Details
F*ck Cancer: A Swear Word Adult Coloring Book For Cancer Patients & Survivors: An Irreverent & Hilarious Antistress Sweary Adult Colouring Gift ... Mindful Meditation & Stress Relief)
by Honey Badger Coloring (Author)
2018 GIFT IDEAS | COLOURING BOOKS FOR GROWN-UPS | ANTISTRESS
F*ck cancer and the cell it rode in on!
---The Honey Badger
Are you looking to blowing off steam by customizing unique coloring pages with some f***ing glitter pens?! Need a good laugh?! Then F*ck Cancer is just what you need. Indulge your inner child as you color imaginative designs long held sacred by folks way more enlightened than you (but who probably also enjoyed cursing). Are you on a path to peace and a tranquil connection to the universe, or are you... View Details
Cancer Caregiving A-to-Z: An At-Home Guide for Patients and Families
by American Cancer Society (Author)
Winner: 2011 National Health Information Award, Silver, Health Promotion/Disease Prevention; 2011 National Indie Excellence Award, Self-Help, General; 2009 National Health Information Award, Silver; 2009 IBPA Benjamin Franklin Award ——— Whether caring for one’s self at home or providing care for a loved one, this indispensable quick reference can improve quality of care and quality of life for those with cancer. Organized in a straight-forward alphabetical format, the book covers more than four dozen critical cancer caregiving topics, from anxiety to weight changes, and is... View Details
Beating Cancer with Nutrition (Fourth Edition) Rev
by Patrick Quillin (Author)
There is good news in the "war on cancer". Optimal nutrition coupled with appropriate medical treatment can dramatically improve the quality and quantity of life and chances for a complete remission for most cancer patients. A well-nourished cancer patient can better manage the disease. Cancer is the number two cause of death in America and the developed nations of the world with one out of four dying from cancer and 38% of women and 43% of men projected to develop cancer over their lifetime. While the overall death rate from cancer has not appreciably declined since... View Details
PROMOTING WELLNESS for prostate cancer patients
by Mark A. Moyad (Author)
Promoting Wellness for Prostate Cancer Patients is a unique educational book for individuals dealing with the many aspects of prostate cancerfrom prevention to treatment and managing the common (and not so common) side effects of conventional therapy.
In this fully updated and redesigned Fourth Edition, Dr. Moyad covers the latest advancements in prostate cancer treatment while providing his trademark no-nonsense analysis on groundbreaking research that is currently underway. A new series of Quick Tips” run throughout the book, where Dr. Moyad shares his secrets to... View Details
What Cancer Cannot Do: Stories of Courage
by Zondervan (Author)
Cancer is so limited.... It cannot cripple life, it cannot shatter hope, it cannot corrode faith, it cannot ... Filled with stories of courage for anyone dealing with cancer, this book combines uplifting Scriptures from the NIV, inspirational quotes, and encouraging stories from both male and female cancer survivors.View Details
MANIFESTO FOR A CANCER PATIENT
by Colleen Huber NMD (Author)
What choices do cancer patients have? Why do those choices seem so few? This book is a manifesto for patient rights and a manual through the cancer journey, from a Naturopathic Medical Doctor. A newly diagnosed cancer patient is told: “There is nothing else that works against your cancer except chemotherapy and radiation. So you are going to start chemo now.” After several chemo drugs are tried over the course of months to years, the cancer patient must then hear: “There is nothing more that can be done for your cancer, and it is time to go to hospice.” Then death is blamed on cancer... View Details