Nav: Home

Transplanted liver cells protect against liver failure after massive hepatectomy surgery

April 25, 2016

Putnam Valley, NY. (April 25, 2016) - Liver failure often occurs after an extensive hepatectomy, which is the surgical resection of the liver. While liver cell transplantation is a useful therapy for acute liver failure after massive hepatectomy, when cells are transplanted through liver portal veins raises the risk of embolization, such as the formation and movement of a blood clot, often with fatal consequences.

Experimenting with rat models, researchers investigated safer ways to transplant liver cells post-extensive hepatectomy and found that transplanting the cells into an extra-hepatic site, such as the intra-mesentery, a fold of membranous tissue on the posterior wall of the abdominal cavity that attaches to the intestinal tract, can help to protect against post-operative liver failure and aid in survival of the remaining liver.

Their study will be published in a future issue of Cell Transplantation and is currently freely available on-line as an unedited, early epub at: http://www.ingentaconnect.com/content/cog/ct/pre-prints/content-CT-1478_Kita_et_al

"The overall mortality due to acute liver failure significantly improved in the transplantation group," said study co-author Dr. Kentaro Yasuchika of the Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

To investigate whether hepatocytes or non-parenchymal cells (NPCs) that secrete a variety of growth factors and participate in liver growth played a more significant role in protecting remnant livers and promoting hepatic regeneration, liver cells harvested from the donor liver tissue were divided into hepatocytes and NPCs, with each transplanted separately in one arm of the study. The researchers found that post-operative liver damage was not prevented by NPCs alone and speculated that the protective effect was mainly because the hepatocytes transplanted into the mesentery contributed to hepatocyte survival and protected against acute liver failure.

"Although transplanted liver cells hardly worked as functional liver cells in the very early period after transplantation, they protected the remaining liver tissue and cells from severe damage after massive hepatectomy, which could have a major effect on survival of the remnant liver," concluded the researchers. "Further experiments should be planned for diseased recipients with chronic liver failure, metabolic live failure, and liver cirrhosis to utilize this technique in a clinical setting."

"Liver failure is a life-threatening condition that has many causes, thus effecting varied, diverse portions of the population," said Dr. Stephen Strom, professor of Cell Transplantation and Regenerative Medicine, Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet, Stockholm, Sweden. "The condition may necessitate surgery, which can lead to augmentation of these complications. The need for additional therapeutic options is keenly felt and future studies should address the safety of this method for translation to patients."
-end-
Contact: Dr. Kentaro Yasuchika, Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawara-cho, Shogoin, Sakyo-ku, Kyoto, Japan,606-8507
Email: kent@kuhp.kyoto_u.ac.jp
Tel: +81-75-751--3242
Fax: +81-75-751-4246

Citation: Kito S, Yasuchika K, Ishii T, Katayama H, Yoshitoshi EY, Ogiso S, Kawai T, Yasuda K, Fukumitsu K, Mizumoto M, Uemoto S. The protective effect of transplanted liver cells into the mesentery on the rescue of acture liver failure after massive hepatectomy. Cell Transplant. Appeared or available on-line: February 15, 2016.

The Coeditors-in-Chief for CELL TRANSPLANTATION are at the Department of Neurosurgery and Brain Repair, Morsani College of Medicine, University of South Florida, Tampa, FL, USA and the Center for Neuropsychiatry, China Medical University Hospital, TaiChung, Taiwan. Contact: Paul R. Sanberg at psanberg@health.usf.edu, Shinn-Zong Lin at shinnzong@yahoo.com.tw, or Associate Editor Samantha Portis at celltransplantation@gmail.com

News release by Florida Science Communications http://www.sciencescribe.net

Cell Transplantation Center of Excellence for Aging and Brain Repair

Related Transplantation Articles:

Study provides clues to improving fecal microbiota transplantation
Results from a placebo-controlled trial provide a strategy for improving fecal microbiota transplantation (FMT) for patients with recurrent Clostridium difficile infection.
Brazil faces major challenges in liver transplantation
A recent analysis indicates that more than 1,700 liver transplantations are performed annually in Brazil.
These days fecal transplantation is no joke
Fecal transplants are increasingly being used to treat certain human illnesses and there has been a dramatic increase in animal experiments involving fecal material.
Transplantation and cell therapy
Key leaders in the field of cellular therapy will highlight new applications to potentially cure patients with blood diseases and infections on the occasion of the 5th Cell Therapy Day.
Elsevier announces the launch of Transplantation Reports
Elsevier, a world-leading provider of scientific, technical, and medical information products and services today announces the launch of Transplantation Reports, a new online-only open access journal covering all areas of transplantation.
Common cause for complications after kidney transplantation identified
The BK polyomavirus often causes complications after kidney transplantation. The research group of Professor Hans H.
Uterine transplantation: Subjects have 'adjusted well to their new life situation'
In October last year the Gothenburg, Sweden, group of Mats Brannstrom announced the world's first live birth following the transplantation of a donated uterus.
The road to successful uterus transplantation to restore fertility
Swedish clinicians recently reported the first live birth after uterus transplantation, which was followed by two more uneventful births and another pregnancy that is near term.
After lung transplantation: Go back to work and feel better
In an original article in Deutsches Ă„rzteblatt International, Hendrik Suhling and coauthors report the findings of the first study ever performed in Germany on the percentage of lung-transplant patients who resume employment after transplantation and the reasons that keep the others from going back to work.
Size of biomarker associated with improved survival following transplantation
Among patients with severe aplastic anemia who received stem cell transplant from an unrelated donor, longer leukocyte (white blood cells) telomere length (a structure at the end of a chromosome) was associated with increased overall survival at five years, according to a study in the Feb.

Related Transplantation Reading:

Handbook of Kidney Transplantation
by Dr. Gabriel M. Danovitch MD (Author)

Kidney Transplantation - Principles and Practice: Expert Consult - Online and Print (Morris,Kidney Transplantation)
by Stuart J. Knechtle MD FACS (Author), Peter J Morris MD PhD FRS FRCS (Author)

Lost in Transplantation: Memoir of an Unconventional Organ Donor
by Whole Heart Publications

Hematopoietic Stem Cell Transplantation: A Manual for Nursing Practice (Second Edition)
by S. A. Ezzone (Author)

Transplantation Pathology Hardback with Online Resource
by Phillip Ruiz (Editor)

Handbook of Kidney Transplantation, Fourth edition
by Gabriel M. Danovitch MD (Editor)

Thomas' Hematopoietic Cell Transplantation, 2 Volume Set: Stem Cell Transplantation
by Stephen J. Forman (Editor), Robert S. Negrin (Editor), Joseph H. Antin (Editor), Frederick R. Appelbaum (Editor)

Kidney Transplantation: The Patient's Guide
by Jacqueline L. Harris RN (Author)

Transplantation of the Liver
by Ronald W. Busuttil MD PhD (Author), Goran B. Klintmalm MD PhD (Author)

Manual of Stem Cell and Bone Marrow Transplantation
by Joseph H. Antin (Author), Deborah Yolin Raley (Author)

Best Science Podcasts 2018

We have hand picked the best science podcasts for 2018. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Circular
We're told if the economy is growing, and if we keep producing, that's a good thing. But at what cost? This hour, TED speakers explore circular systems that regenerate and re-use what we already have. Guests include economist Kate Raworth, environmental activist Tristram Stuart, landscape architect Kate Orff, entrepreneur David Katz, and graphic designer Jessi Arrington.
Now Playing: Science for the People

#504 The Art of Logic
How can mathematics help us have better arguments? This week we spend the hour with "The Art of Logic in an Illogical World" author, mathematician Eugenia Cheng, as she makes her case that the logic of mathematics can combine with emotional resonance to allow us to have better debates and arguments. Along the way we learn a lot about rigorous logic using arguments you're probably having every day, while also learning a lot about our own underlying beliefs and assumptions.