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A close look into the barley genome

April 27, 2017

Malted barley is used in brewing, and in the unmalted form the grain is processed into pearl barley or flour. A large portion of the world's production is processed into animal food. The objective of barley cultivation is to develop varieties that are resistant to pathogens and that tolerate climate fluctuations.

"The barley genome, which is almost twice as large as the human genome with a very high portion of repetitive elements (transposons), presents a challenge for complete sequencing," says first author Heidrun Gundlach, PGSB. "This is why there was previously only a preliminary, incomplete and incorrect genome sequence."

Now Gundlach, together with colleagues in an international consortium, has succeeded in creating a new, high quality reference genome sequence for barley, decoding the chromosomal architecture of such large genomes, and getting to the heart of the interaction between genes and transposons.

"Our data allow the first detailed analysis of agronomically and industrially important gene families such as alpha-amylase, an enzyme with special importance in the brewing process," adds Dr. Manuel Spannagl, also PGSB. With their new reference, researchers also want to examine the natural diversity of barley at the genomic level. Their findings could significantly accelerate the process to cultivate new varieties, for example, in light of the climate change.

The next step calls for the sequencing, analysis, and genomic comparison of further types of barley. Scientists want to determine important characteristics, such as resistances of individual varieties, and apply them to other types.
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Further information

Some of the partners who participated in the work were the Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, the German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, and the Helmholtz Zentrum München, Plant Genome and Systems Biology Department (PGSB).

Original publication: Martin Mascher, Heidrun Gundlach et al. (2017): A chromosome conformation capture ordered sequence of the barley genome. Nature, doi:10.1038/nature22043. Abstract...

The Helmholtz Zentrum München, the German Research Center for Environmental Health, pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle. The Helmholtz Zentrum München is headquartered in Neuherberg in the north of Munich and has about 2,300 staff members. It is a member of the Helmholtz Association, a community of 18 scientific-technical and medical-biological research centers with a total of about 37,000 staff members.

The Research Unit Plant Genome and Systems Biology (PGSB) plant genomics group focuses on the analysis of plant genomes, using bioinformatic techniques. To store and manage the data, we developed a database, PlantsDB, that aims to provide a data and information resource for individual plant species. In addition, PlantsDB provides a platform for integrative and comparative plant genome research.

Helmholtz Zentrum München - German Research Center for Environmental Health

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