Nav: Home

Contemporary update to PROGRESS-CTO International Registry shows successful outcomes

April 27, 2018

SAN DIEGO, April 26, 2018 - A significant update to the PROGRESS-CTO (PROspective Global Registry for the Study of Chronic Total Occlusion Intervention) International Registry was presented today as late-breaking clinical science at Society for Cardiovascular Angiography and Interventions (SCAI) Scientific Sessions 2018. The study includes results of Chronic Total Occlusion Percutaneous Intervention (CTO PCI) for more than 3,000 patients across 20 centers in the United States, Europe, and Russia. The new data from the PROGRESS-CTO registry are representative of contemporary practice and outcomes.

The World Health Organization estimates that 7.3 million deaths around the world are due to coronary heart disease making it the second cause of death in people under the age of 59 after HIV/AIDS, and reaching the first position in those 60 years and older (European Heart Journal). Approximately 20 percent of such patients are known to have a complication from CAD called CTO, or complete blockages of the arteries that have typically been present for more than three months (NCBI). CTO PCI is a minimally invasive procedure that has been evolving with constant improvement of equipment and techniques.

The authors outline contemporary outcomes of CTO PCI by analyzing the clinical, angiographic and procedural characteristics of 3,122 CTO interventions performed in 3,055 patients at 20 centers in the United States (17), Europe (2) and Russia (1). The researchers analyzed success rates of antegrade wire escalation, antegrade dissection and re-entry and the retrograde approach on CTO interventions performed.

The mean age was 65?10 years and 85 percent of the patients were men with high prevalence of diabetes (43 percent), prior myocardial infarction (MI) (46 percent), prior coronary artery bypass graft surgery (33 percent) and prior PCI (65 percent). The overall technical and procedural success rate was 87 percent and 85 percent, respectively. The rate of in-hospital major complications was 3 percent (composite of death 0.9 percent), acute MI (1.1 percent), stroke (0.3 percent), tamponade (0.9 percent), emergency surgery (0.2 percent) and re-PCI (0.4 percent). The success rates for the antegrade wire escalation, antegrade dissection and re-entry and retrograde approach were 87.3 percent, 89.7 percent and 83 percent, respectively.

"The high success and acceptable complication rates suggest that at experienced centers CTO PCI can provide significant clinical benefits to the patients," said Peter Tajti, MD, Abbott Northwestern Hospital, Minneapolis Heart Institute in Minneapolis, MN. "The study results can facilitate discussions with both patients and physicians about the risk to benefits of the procedure and guide decision making on CTO PCI."

The authors are working on a new, multi-center study including centers from around the world to further assess the effect of CTO PCI symptoms when compared to the placebo-controlled procedure.

Session Details: "Late-Breaking Clinical Science II: The Hybrid Approach of Percutaneous Coronary Interventions for Chronic Total Occlusion: Update from the PROGRESS-CTO (PROspective Global Registry for the Study of Chronic Total Occlusion Intervention) International Registry" [April 26, 2018, 11:00 a.m. - 12:00 p.m. PDT, Seaport DE]
About SCAI:

The Society for Cardiovascular Angiography and Interventions is a 4,200-member professional organization representing invasive and interventional cardiologists in approximately 75 nations. SCAI's mission is to promote excellence in invasive/interventional cardiovascular medicine through physician education and representation, and advancement of quality standards to enhance patient care.

For more information about the SCAI 2018 Scientific Sessions, visit

Society for Cardiovascular Angiography and Interventions

Related Age Articles:

A mother's age doesn't matter
A mother's advanced age at childbirth is not the reason for the elevated risks of low birth weight or preterm birth -- such risks may instead be related to individual circumstances and behavioral patterns of the mother.
How the visual cortex changes from birth to old age
A study of post-mortem brain tissue reveals the human primary visual cortex (V1) develops gradually throughout life.
What the age of your brain says about you
Researchers used neuroimages of the brain to identify biomarkers that show how the structures of a person's brain age.
More than a 'gut feeling' on cause of age-associated inflammation
Bowdish and her colleagues raised mice in germ-free conditions and compared them to their conventionally raised counterparts.
Rapid blood pressure drops in middle age linked to dementia in old age
Middle-aged people who experience temporary blood pressure drops that often cause dizziness upon standing up may be at an increased risk of developing cognitive decline and dementia 20 years later, new Johns Hopkins Bloomberg School of Public Health research suggests.
Regular aerobic exercise beginning in middle age may lessen severity of stroke in old age
Regular aerobic exercise may protect the collateral circulation and lessen the severity of strokes later in life.
Inception of the last ice age
A new model reconstruction shows in exceptional detail the evolution of the Eurasian ice sheet during the last ice age.
BU study finds patterns of biomarkers predict how well people age, risks of age-related disease
Levels of specific biomarkers, or chemicals found in the blood, can be combined to produce patterns that signify how well a person is aging and his or risk for future aging-related diseases, according to a new study by researchers at the Boston University Schools of Public Health and Medicine and Boston Medical Center.
More women sexually active into old age
Although many of us don't want to think about grandma still 'getting it on,' multiple studies show that older women are still sexually active beyond their seventh decade of life.
How even our brains get 'slacker' as we age
New research from Newcastle University, UK, in collaboration with the Federal University of Rio de Janeiro, investigated the way the human brain folds and how this 'cortical folding' changes with age.

Related Age Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Do animals grieve? Do they have language or consciousness? For a long time, scientists resisted the urge to look for human qualities in animals. This hour, TED speakers explore how that is changing. Guests include biological anthropologist Barbara King, dolphin researcher Denise Herzing, primatologist Frans de Waal, and ecologist Carl Safina.
Now Playing: Science for the People

#SB2 2019 Science Birthday Minisode: Mary Golda Ross
Our second annual Science Birthday is here, and this year we celebrate the wonderful Mary Golda Ross, born 9 August 1908. She died in 2008 at age 99, but left a lasting mark on the science of rocketry and space exploration as an early woman in engineering, and one of the first Native Americans in engineering. Join Rachelle and Bethany for this very special birthday minisode celebrating Mary and her achievements. Thanks to our Patreons who make this show possible! Read more about Mary G. Ross: Interview with Mary Ross on Lash Publications International, by Laurel Sheppard Meet Mary Golda...