Nav: Home

Contemporary update to PROGRESS-CTO International Registry shows successful outcomes

April 27, 2018

SAN DIEGO, April 26, 2018 - A significant update to the PROGRESS-CTO (PROspective Global Registry for the Study of Chronic Total Occlusion Intervention) International Registry was presented today as late-breaking clinical science at Society for Cardiovascular Angiography and Interventions (SCAI) Scientific Sessions 2018. The study includes results of Chronic Total Occlusion Percutaneous Intervention (CTO PCI) for more than 3,000 patients across 20 centers in the United States, Europe, and Russia. The new data from the PROGRESS-CTO registry are representative of contemporary practice and outcomes.

The World Health Organization estimates that 7.3 million deaths around the world are due to coronary heart disease making it the second cause of death in people under the age of 59 after HIV/AIDS, and reaching the first position in those 60 years and older (European Heart Journal). Approximately 20 percent of such patients are known to have a complication from CAD called CTO, or complete blockages of the arteries that have typically been present for more than three months (NCBI). CTO PCI is a minimally invasive procedure that has been evolving with constant improvement of equipment and techniques.

The authors outline contemporary outcomes of CTO PCI by analyzing the clinical, angiographic and procedural characteristics of 3,122 CTO interventions performed in 3,055 patients at 20 centers in the United States (17), Europe (2) and Russia (1). The researchers analyzed success rates of antegrade wire escalation, antegrade dissection and re-entry and the retrograde approach on CTO interventions performed.

The mean age was 65?10 years and 85 percent of the patients were men with high prevalence of diabetes (43 percent), prior myocardial infarction (MI) (46 percent), prior coronary artery bypass graft surgery (33 percent) and prior PCI (65 percent). The overall technical and procedural success rate was 87 percent and 85 percent, respectively. The rate of in-hospital major complications was 3 percent (composite of death 0.9 percent), acute MI (1.1 percent), stroke (0.3 percent), tamponade (0.9 percent), emergency surgery (0.2 percent) and re-PCI (0.4 percent). The success rates for the antegrade wire escalation, antegrade dissection and re-entry and retrograde approach were 87.3 percent, 89.7 percent and 83 percent, respectively.

"The high success and acceptable complication rates suggest that at experienced centers CTO PCI can provide significant clinical benefits to the patients," said Peter Tajti, MD, Abbott Northwestern Hospital, Minneapolis Heart Institute in Minneapolis, MN. "The study results can facilitate discussions with both patients and physicians about the risk to benefits of the procedure and guide decision making on CTO PCI."

The authors are working on a new, multi-center study including centers from around the world to further assess the effect of CTO PCI symptoms when compared to the placebo-controlled procedure.

Session Details: "Late-Breaking Clinical Science II: The Hybrid Approach of Percutaneous Coronary Interventions for Chronic Total Occlusion: Update from the PROGRESS-CTO (PROspective Global Registry for the Study of Chronic Total Occlusion Intervention) International Registry" [April 26, 2018, 11:00 a.m. - 12:00 p.m. PDT, Seaport DE]
About SCAI:

The Society for Cardiovascular Angiography and Interventions is a 4,200-member professional organization representing invasive and interventional cardiologists in approximately 75 nations. SCAI's mission is to promote excellence in invasive/interventional cardiovascular medicine through physician education and representation, and advancement of quality standards to enhance patient care.

For more information about the SCAI 2018 Scientific Sessions, visit

Society for Cardiovascular Angiography and Interventions

Related Age Articles:

New evidence of the Sahara's age
The Sahara Desert is vast, generously dusty, and surprisingly shy about its age.
When considering presidential candidates, age is just a number
A new white paper shows there is no such thing as being too old to be president.
Why sex becomes less satisfying with age
The number of women regularly having sex declines with age, and the number of women enjoying sex postmenopause is even lower.
A new 'golden' age for electronics?
Scientists at Nagoya University, Japan, have created materials that shrink uniformly in all directions when heated under normal everyday conditions, using a cheap and industrially scalable process.
The age of water
Groundwater in Egypt's aquifers may be as much as 200,000 years old and that's important to know as officials in that country seek to increasing the use of groundwater, especially in the Eastern Desert, to mitigate growing water stress and allow for agricultural projects.
At what age do you feel 65?
At what age do you feel 65? New study reveals wide variations in how well or poorly people age.
What's age got to do with it?
It's often said: it's not how old you are, it's how old you feel.
Age is more than just a number: Machine learning may predict if you're in for a healthy old age
A collaborative team at the Salk Institute analyzed skin cells from the very young to the very old and looked for molecular signatures that can be predictive of age.
Age at which women experience their first period is linked to their sons' age at puberty
The age at which young women experience their first menstrual bleeding is linked to the age at which their sons start puberty, according to the largest study to investigate this association in both sons and daughters.
Why does sleep become disrupted in old age?
The brain maintains its ability to generate local neural oscillations during sleep throughout the lifespan, according to a study of young and old mice published in JNeurosci.
More Age News and Age Current Events

Top Science Podcasts

We have hand picked the top science podcasts of 2019.
Now Playing: TED Radio Hour

In & Out Of Love
We think of love as a mysterious, unknowable force. Something that happens to us. But what if we could control it? This hour, TED speakers on whether we can decide to fall in — and out of — love. Guests include writer Mandy Len Catron, biological anthropologist Helen Fisher, musician Dessa, One Love CEO Katie Hood, and psychologist Guy Winch.
Now Playing: Science for the People

#543 Give a Nerd a Gift
Yup, you guessed it... it's Science for the People's annual holiday episode that helps you figure out what sciency books and gifts to get that special nerd on your list. Or maybe you're looking to build up your reading list for the holiday break and a geeky Christmas sweater to wear to an upcoming party. Returning are pop-science power-readers John Dupuis and Joanne Manaster to dish on the best science books they read this past year. And Rachelle Saunders and Bethany Brookshire squee in delight over some truly delightful science-themed non-book objects for those whose bookshelves are already full. Since...
Now Playing: Radiolab

An Announcement from Radiolab