Researchers weave human tissue into new blood vessels

April 27, 2020

Bethesda, MD - Researchers have used threads made of engineered human tissue to weave blood vessels that could one day help repair diseased or damaged blood vessels.

"Blood vessels are just one example of what can be done with our new textile approach to tissue engineering," said research team leader Nicolas L'Heureux, PhD, director of research at Inserm/University of Bordeaux in France. "It can be used to make practically any shape by weaving, braiding or knitting the threads and allows very good control of the mechanical properties of the final product."

Synthetic blood vessel grafts made of woven synthetic polymer yarn are sometimes used to replace diseased arteries. However, the body recognizes the polymer as foreign, which causes blood to clot on these grafts and creates a scar that can clog the tube. Because blood vessels created with the new textile-based approach don't require any synthetic materials, they are likely to be accepted and become part of the body.

L'Heureux was scheduled to present this research at the American Association for Anatomy annual meeting in San Diego this month. Though the meeting, to be held in conjunction with the 2020 Experimental Biology conference, was canceled in response to the COVID-19 outbreak, the research team's abstract was published in this month's issue of TheFASEB Journal.

The threads used for the new textile approach are made of a biomaterial called cell-assembled matrix (CAM) developed by L'Heureux's research team. CAM is mostly collagen, which is the most abundant protein the body and the protein that makes tissues and organs mechanically strong. CAM is well-accepted by the body because it is entirely human and not chemically modified.

In the new study, the researchers show that they can make yarn by cutting CAM sheets into ribbons that can be used directly or twisted into threads. They used these threads to weave blood vessels that displayed excellent mechanical properties without the need for any synthetic scaffolding or chemical treatments.

"It is time consuming and costly to get CAM layers to stick together," said L'Heureux. "The new textile assembly approach is not only more versatile but also has the potential to be automated which would make it even faster, easier and cheaper to use."

Because a collagen scaffold is an integral part of most organs, CAM could be used to jumpstart the regeneration of many tissues and organs. So far it has been used to make lab-grown skin for burn patients and guides that help repair nerve injuries.

The researchers are now building additional blood vessel prototypes and learning more about the best ways to handle CAM threads and ribbons. They will soon start testing the vascular grafts in animals as a step toward eventual clinical trials in people.
-end-
Contact the media team for more information.

Images available.


About Experimental Biology 2020

Experimental Biology is an annual meeting that attracts more than 12,000 scientists and exhibitors from five host societies and more than two dozen guest societies. With a mission to share the newest scientific concepts and research findings shaping clinical advances, the meeting offers an unparalleled opportunity for exchange among scientists from across the U.S. and the world who represent dozens of scientific areas, from laboratory to translational to clinical research. http://www.experimentalbiology.org #expbio

About the American Association for Anatomy (AAA)

The American Association for Anatomy is an international membership organization of biomedical researchers and educators specializing in the structural foundation of health and disease. AAA connects gross anatomists, neuroscientists, developmental biologists, physical anthropologists, cell biologists, physical therapists, and others to advance the anatomical sciences through research, education, and professional development. To join, visit anatomy.org.

About The FASEB Journal

Receive monthly highlights from The FASEB Journal by e-mail. Sign up at http://www.faseb.org/fjupdate.aspx. The FASEB Journal is published by the Federation of the American Societies for Experimental Biology (FASEB). It is among the most cited biology journals worldwide according to the Institute for Scientific Information and has been recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century.

Find more press materials at: https://www.eurekalert.org/meetings/eb/2020/newsroom/

Experimental Biology

Related Science Articles from Brightsurf:

75 science societies urge the education department to base Title IX sexual harassment regulations on evidence and science
The American Educational Research Association (AERA) and the American Association for the Advancement of Science (AAAS) today led 75 scientific societies in submitting comments on the US Department of Education's proposed changes to Title IX regulations.

Science/Science Careers' survey ranks top biotech, biopharma, and pharma employers
The Science and Science Careers' 2018 annual Top Employers Survey polled employees in the biotechnology, biopharmaceutical, pharmaceutical, and related industries to determine the 20 best employers in these industries as well as their driving characteristics.

Science in the palm of your hand: How citizen science transforms passive learners
Citizen science projects can engage even children who previously were not interested in science.

Applied science may yield more translational research publications than basic science
While translational research can happen at any stage of the research process, a recent investigation of behavioral and social science research awards granted by the NIH between 2008 and 2014 revealed that applied science yielded a higher volume of translational research publications than basic science, according to a study published May 9, 2018 in the open-access journal PLOS ONE by Xueying Han from the Science and Technology Policy Institute, USA, and colleagues.

Prominent academics, including Salk's Thomas Albright, call for more science in forensic science
Six scientists who recently served on the National Commission on Forensic Science are calling on the scientific community at large to advocate for increased research and financial support of forensic science as well as the introduction of empirical testing requirements to ensure the validity of outcomes.

World Science Forum 2017 Jordan issues Science for Peace Declaration
On behalf of the coordinating organizations responsible for delivering the World Science Forum Jordan, the concluding Science for Peace Declaration issued at the Dead Sea represents a global call for action to science and society to build a future that promises greater equality, security and opportunity for all, and in which science plays an increasingly prominent role as an enabler of fair and sustainable development.

PETA science group promotes animal-free science at society of toxicology conference
The PETA International Science Consortium Ltd. is presenting two posters on animal-free methods for testing inhalation toxicity at the 56th annual Society of Toxicology (SOT) meeting March 12 to 16, 2017, in Baltimore, Maryland.

Citizen Science in the Digital Age: Rhetoric, Science and Public Engagement
James Wynn's timely investigation highlights scientific studies grounded in publicly gathered data and probes the rhetoric these studies employ.

Science/Science Careers' survey ranks top biotech, pharma, and biopharma employers
The Science and Science Careers' 2016 annual Top Employers Survey polled employees in the biotechnology, biopharmaceutical, pharmaceutical, and related industries to determine the 20 best employers in these industries as well as their driving characteristics.

Three natural science professors win TJ Park Science Fellowship
Professor Jung-Min Kee (Department of Chemistry, UNIST), Professor Kyudong Choi (Department of Mathematical Sciences, UNIST), and Professor Kwanpyo Kim (Department of Physics, UNIST) are the recipients of the Cheong-Am (TJ Park) Science Fellowship of the year 2016.

Read More: Science News and Science Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.