FDG-PET accurate for evaluating lung tumor destruction from radiofrequency ablation

May 01, 2006

FDG-PET can be used to assess the amount of tumor destruction after radiofrequency ablation (RFA)--the use of heat to destroy tumors--for the treatment of lung tumors and may provide more valuable information than CT alone, according to a new study.

For the study, researchers assessed 10 tumors in 10 patients who had lung tumors treated with CT-guided RFA and had PET scans both prior to RFA and following RFA. The researchers found that in seven out of 11 RFA treatments for the 10 patients, follow-up PET demonstrated persistent tumor activity. Two of the patients showed no activity on the follow-up PET, suggesting complete destruction of any active tumor. One patient had no definite change in the appearance of the mass, and another had a smaller lesion on follow-up PET.

"Usually, CT is used to assess tumor destruction, but CT cannot tell you whether a tumor is still alive--that is, actively metabolizing glucose--or dead in the area of destruction. It can also be difficult to assess how much of the ablated area is caused by an inflammatory reaction to the procedure. By using PET, the tumor cells that are still alive light up and the radiologist can better assess how much residual active tumor is left," said Jennifer Daly, MD, of the Newton-Wellesley Hospital in Newton, MA, and lead author of the study.

According to the researchers, without effective follow-up imaging, the radiologist has to gauge how successful it was based only on the patient's improvement in pain and maybe what is possibly seen on a post-ablation CT. "You don't really know for sure how much active tumor is destroyed unless you compare pre- and post-PET scans," said Dr. Daly.

The full results of the study will be presented on Monday, May 1, 2006 during the American Roentgen Ray Society Annual Meeting in Vancouver, BC.
-end-
About ARRS
The American Roentgen Ray Society (ARRS) was founded in 1900 and is the oldest radiology society in the United States. Radiologists from all over the world attend the ARRS Annual Meeting to take part in instructional courses, scientific paper presentations, symposiums, new issues forums and scientific and commercial exhibits related to the field of radiology. The ARRS is named after Wilhelm Röentgen, who discovered the x-ray in 1895.

American College of Radiology

Related Tumors Articles from Brightsurf:

A viable vaccine for tough tumors
While immunotherapies work well for some cancers, others are immune-resistant and condemn patients to the severe side effects of long-term chemo treatment.

Women could conceive after ovarian tumors
Women receiving fertility-sparing surgery for treatment of borderline ovarian tumours were able to have children, a study from Karolinska Institutet in Sweden published in Fertility & Sterility shows.

Attacking tumors from the inside
A new technology that allows researchers to peer inside malignant tumors shows that two experimental drugs can normalize aberrant blood vessels, oxygenation, and other aspects of the tumor microenvironment in non-small cell lung cancer (NSCLC), helping to suppress the tumor's growth and spread, UT Southwestern researchers report.

Directing nanoparticles straight to tumors
Modern anticancer therapies aim to attack tumor cells while sparing healthy tissue.

A solid vaccine for liquid tumors
Acute myeloid leukemia (AML) is a deadly blood cancer that kills most of its victims within five years.

Evolutionarily novel genes work in tumors
A team of scientists from Peter the Great St. Petersburg Polytechnic University studied the evolutionary ages of human genes and identified a new class of them expressed in tumors -- tumor specifically expressed, evolutionarily novel (TSEEN) genes.

Identification of all types of germ cells tumors
Germ cell tumors were considered very heterogeneous and diverse, until recently.

Laser light detects tumors
A team of researchers from Jena presents a groundbreaking new method for the rapid, gentle and reliable detection of tumors with laser light.

Better prognosticating for dogs with mammary tumors
For dogs with mammary tumors, deciding a course of treatment can depend on a variety of factors, some of which may seem to contradict one another.

The evolution of brain tumors
Scientists from the German Cancer Research Center found in a recent study that only three different genetic alterations drive the early development of malignant glioblastomas.

Read More: Tumors News and Tumors Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.